SNP information rs10455872

Research and publications:

  20032323   Genetic variants associated with Lp(a) lipoprotein level and coronary disease.

  20160194   Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians.

  20605575   Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus.

  20729558   Improved prediction of cardiovascular disease based on a panel of single nucleotide polymorphisms identified through genome-wide association studies.

  21127300   Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk.

  21252144   Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study.

  21283670   Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.

  21305047   Variation in LPA is associated with Lp(a) levels in three populations from the Third National Health and Nutrition Examination Survey.

  21369780   Genome-wide association studies in atherosclerosis.

  21592478   Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts.

  21749171   Lipoprotein(a): genotype-phenotype relationship and impact on atherogenic risk.

  21875899   Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour.

  21900290   Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.

  21966275   Large-scale gene-centric analysis identifies novel variants for coronary artery disease.

  22144573   Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.

  22368281   Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a).

  22560621   Cost-effectiveness model of use of genetic testing as an aid in assessing the likely benefit of aspirin therapy for primary prevention of cardiovascular disease.

  22629316   Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

  22898070   Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.

  22992668   Pharmacogenomics knowledge for personalized medicine.

  23100282   Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

  23278389   Two rare variants explain association with acute myocardial infarction in an extended genomic region including the apolipoprotein(A) gene.

  23375930   Extreme lipoprotein(a) levels and improved cardiovascular risk prediction.

  23696881   Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.

  23735648   Validation and quantification of genetic determinants of lipoprotein-a levels and predictive value for angiographic coronary artery disease.

  23903772   Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with corona

  24089516   The association between circulating lipoprotein(a) and type 2 diabetes: is it causal?

  24161338   Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population.

  24704946   Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: a prospective Mendelian randomization study and replication in a case-control cohort.

  24760552   Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts.

  24776095   LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography.

  24834361   Update on abdominal aortic aneurysm research: from clinical to genetic studies.

  24903972   Genetic predisposition to calcific aortic stenosis and mitral annular calcification.

  25171759   The MYLIP p.N342S polymorphism is associated with response to lipid-lowering therapy in Brazilian patients with familial hypercholesterolemia.

  25314652   Low "quotient" Lp(a) concentration mediates autoimmune activation and independently predicts cardiometabolic risk.

  25350695   Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

  25575512   Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.

  25953646   Heritability of Biomarkers of Oxidized Lipoproteins: Twin Pair Study.

  26178435   Cardiovascular pharmacogenomics: current status and future directions.

  26446360   Mendelian randomization studies of biomarkers and type 2 diabetes.

  26677855   Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.

  26686871   Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies.

  26896185   Human Genetics and the Causal Role of Lipoprotein(a) for Various Diseases.

  26900838   Apolipoprotein(a) Kringle-IV Type 2 Copy Number Variation Is Associated with Venous Thromboembolism.

  26946290   Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk.

  26958643   Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis.

  26971241   Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans.

  27005778   Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

  27417585   Lipoprotein Apheresis for Lipoprotein(a)-Associated Cardiovascular Disease: Prospective 5 Years of Follow-Up and Apolipoprotein(a) Characterization.

  27589735   A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification.

  27621937   A Case-Control Study of the Relationship Between SLC22A3-LPAL2-LPA Gene Cluster Polymorphism and Coronary Artery Disease in the Han Chinese Population.

  27716211   A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics.

  27775101   Incorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response.

  27831500   LPA Gene, Ethnicity, and Cardiovascular Events.

  28167353   Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants.

  28408323   Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis.

  28426714   A genetic risk score for CAD, psychological stress, and their interaction as predictors of CAD, fatal MI, non-fatal MI and cardiovascular death.

  28566218   Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.

  28572160   Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease: The Copenhagen General Population Study.

  28838919   Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort).

  28866807   Association between lipoprotein(a) level and type 2 diabetes: no evidence for a causal role of lipoprotein(a) and insulin.

  28877919   High Lipoprotein(a) and Low Risk of Major Bleeding in Brain and Airways in the General Population: a Mendelian Randomization Study.

  29128868   Association of LPA Variants With Aortic Stenosis: A Large-Scale Study Using Diagnostic and Procedural Codes From Electronic Health Records.

  29309886   The association of polymorphic variants, rs2267788, rs1333049 and rs2383207 with coronary artery disease, its severity and presentation in North Indian population.

  29703846   LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins.

  29988570   GWAS Reveal Targets in Vessel Wall Pathways to Treat Coronary Artery Disease.

  30482443   Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis.

  30594920   Investigation of LPA sequence variants rs6415084, rs3798220 with conventional coronary artery disease in Iranian CAD patients.

  30608559   High lipoprotein(a) and high risk of mortality.

  30759150   Using topic modeling via non-negative matrix factorization to identify relationships between genetic variants and disease phenotypes: A case study of Lipoprotein(a) (LPA).

  31103339   LPA genotype is associated with premature cardiovascular disease in familial hypercholesterolemia.

  31188921   The rs10455872-G allele of the LPA gene is associated with high lipoprotein(a) levels and increased aortic valve calcium in a Mexican adult population.

  31272552   Elevated Lipoprotein(a) and Risk of Ischemic Stroke.

  31327478   Statin treatment increases lipoprotein(a) levels in subjects with low molecular weight apolipoprotein(a) phenotype.

  31455005   Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification.

  31481563   Cohort profile: role of lipoproteins in cardiovascular disease-the LipidCardio study.

  31553307   Mapping ICD-10 and ICD-10-CM Codes to Phecodes: Workflow Development and Initial Evaluation.

  31824394   The Association of SNPs Located in the CDKN2B-AS1 and LPA Genes With Carotid Artery Stenosis and Atherogenic Stroke.

  32152647   Lipoprotein(a) plasma levels are not associated with incident microvascular complications in type 2 diabetes mellitus.

  32220223   Association between lipoprotein(a) (Lp(a)) levels and Lp(a) genetic variants with coronary artery calcification.

  32284623   CORONARY ARTERY CALCIUM IS ASSOCIATED WITH LPA GENE VARIANT RS7765803-C IN MEXICAN MESTIZO POPULATION. THE GEA PROJECT.

  32343731   A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter.

  32466883   Ascertainment Bias in the Association Between Elevated Lipoprotein(a) and Familial Hypercholesterolemia.

  32577944   Plasma lipoprotein(a) concentration as an independent predictor of hemodynamic progression of aortic valve stenosis.

  32681934   Coronary artery disease and the risk-associated LPA variants, rs3798220 and rs10455872, in patients with suspected familial hypercholesterolaemia.

  32964493   Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network.

  33100089   Correlations between lipoprotein(a) gene polymorphisms and calcific aortic valve disease and coronary heart disease in Han Chinese.

  33170161   Genetic test for the prescription of diets in support of physical activity.

  33724357   Low lipoprotein(a) levels and risk of disease in a large, contemporary, general population study.

  33872986   Prevalence and influence of LPA gene variants and isoform size on the Lp(a)-lowering effect of pelacarsen.

  34216874   Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at RISK (PARISK) study.

  34903381   Elevated lipoprotein(a) in mitral and aortic valve calcification and disease: The Copenhagen General Population Study.

  35207726   Immune Response and Lipid Metabolism Gene Polymorphisms Are Associated with the Risk of Obesity in Middle-Aged and Elderly Patients.

  35246583   Elevated lipoprotein(a) and genetic polymorphisms in the LPA gene may predict cardiovascular events.

  35379196   Analysis of 61 SNPs from the CAD specific genomic loci reveals unique set of SNPs as significant markers in the Southern Indian population of Hyderabad.