SNP information rs3135506

Research and publications:

  12417524   Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels.

  12417525   Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.

  17357083   Medical sequencing at the extremes of human body mass.

  17903299   A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

  18441017   An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.

  18596051   Polygenic determinants of severe hypertriglyceridemia.

  18660489   Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

  18789138   The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides.

  18801202   Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease.

  18974842   Gender differences in genetic risk profiles for cardiovascular disease

  19018513   The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.

  19041386   Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

  19056598   Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.

  19057464   Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study.

  19148283   Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.

  19435741   Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.

  19629056   Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin.

  19787382   Introduction to the DISRUPT postprandial database: subjects, studies and methodologies

  19802338   Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replicatio

  19878569   Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.

  19910639   Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.

  20031591   Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.

  20054229   Gene-gene interaction between APOA5 and USF1: two candidate genes for the metabolic syndrome.

  20395964   Different effects of apolipoprotein A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins.

  20400780   Candidate gene association resource (CARe): design, methods, and proof of concept.

  20406163   Fenofibrate and metabolic syndrome.

  20429872   Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study

  20674306   The APOA1/C3/A4/A5 cluster and markers of allostatic load in the Boston Puerto Rican Health Study.

  20831840   Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned.

  20876667   Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review.

  21206424   Novel polymorphisms associated with tacrolimus trough concentrations: results from a multicenter kidney transplant consortium.

  21282362   Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.

  21288825   Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study.

  21463987   Cerebrovascular atherosclerosis in type III hyperlipidemia is modulated by variation in the apolipoprotein A5 gene.

  21466885   Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent.

  21548985   Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood.

  21671989   Dosing equation for tacrolimus using genetic variants and clinical factors.

  21738485   Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.

  21773006   Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach.

  21860704   Implications of discoveries from genome-wide association studies in current cardiovascular practice.

  22239554   Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia.

  22303299   A grand challenge for nutrigenomics.

  22425169   Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol.

  22460246   Influence of genetic variants in the apolipoprotein A5 and C3 gene on lipids, lipoproteins, and its association with coronary artery disease in Indians.

  22833659   Gender and single nucleotide polymorphisms in MTHFR, BHMT, SPTLC1, CRBP2, CETP, and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults.

  23065249   Apolipoprotein A5 polymorphisms in Turkish population: association with serum lipid profile and risk of ischemic stroke.

  23151256   APOA5 Q97X mutation identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family.

  23497168   Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population.

  23656756   Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults.

  24402875   Genetic association of lipid metabolism related SNPs with myocardial infarction in the Pakistani population.

  24684850   Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients.

  24725463   Analysis of common and coding variants with cardiovascular disease in the Diabetes Heart Study.

  24886709   Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.

  25176936   Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia.

  25205864   Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study.

  25313938   Influences of APOA5 variants on plasma triglyceride levels in Uyghur population.

  25500319   Association between polymorphisms in genes involved in lipid metabolism and immunological status in chronically HIV-infected patients.

  25587205   Association of polymorphisms of genes involved in lipid metabolism with blood pressure and lipid values in mexican hypertensive individuals.

  25770687   APOA5 variants predispose hyperlipidemic patients to atherogenic dyslipidemia and subclinical atherosclerosis.

  26365620   Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men.

  26365669   Interaction of dietary fat intake with APOA2, APOA5 and LEPR polymorphisms and its relationship with obesity and dyslipidemia in young subjects.

  26446360   Mendelian randomization studies of biomarkers and type 2 diabetes.

  26679785   Apolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis.

  26702748   The Relation between Metabolic Syndrome Risk Factors and Genetic Variations of Apolipoprotein V in Relation with Serum Triglyceride and HDL-C Level.

  27036123   Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.

  27067897   Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients.

  27222817   Association of G894T eNOS, 4G/5G PAI and T1131C APOA5 polymorphisms with susceptibility to myocardial infarction in Morocco.

  27227539   The Contribution of GWAS Loci in Familial Dyslipidemias.

  27257688   Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India.

  27453504   An exome array study of the plasma metabolome.

  27496343   Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology.

  27677442   Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes.

  28102463   Marked Differences of Haplotype Tagging SNP Distribution, Linkage, and Haplotype Profile of APOA5 Gene in Roma Population Samples.

  28290785   [Genetic Risk Factors of Macrovascular Complications in Patients With Type 2 Diabetes].

  28624160   Association of apolipoprotein A5 gene variants with metabolic syndrome in Tunisian population.

  28730827   Glucose added to a fat load suppresses the postprandial triglyceridemia response in carriers of the -1131C and 56G variants of the APOA5 gene.

  28865324   The impact of APOA5, APOB, APOC3 and ABCA1 gene polymorphisms on ischemic stroke: Evidence from a meta-analysis.

  29309886   The association of polymorphic variants, rs2267788, rs1333049 and rs2383207 with coronary artery disease, its severity and presentation in North Indian population.

  29688369   The SNPcurator: literature mining of enriched SNP-disease associations.

  30024021   Analysis of causal effect of APOA5 variants on premature coronary artery disease.

  30182779   Genetic susceptibility to cerebrovascular disease: A systematic review.

  30409984   Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics.

  30584432   Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study.

  30600310   Impact of polymorphism of selected genes on the diagnosis of type 2 diabetes in patients with obstructive sleep apnea.

  31397093   Phenotypic severity in a family with MEND syndrome is directly associated with the accumulation of potentially functional variants of cholesterol homeostasis genes.

  31903892   Strong Association between APOA5 Gene Polymorphisms and Hypertriglyceridaemic Episodes.

  32725151   Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa.

  32832146   Association of c.56C > G (rs3135506) Apolipoprotein A5 Gene Polymorphism with Coronary Artery Disease in Moroccan Subjects: A Case-Control Study and an Updated Meta-Analysis.

  34131278   Genetic polymorphisms associated with obesity in the Arab world: a systematic review.

  35387194   Personalized Dietary Recommendations Based on Lipid-Related Genetic Variants: A Systematic Review.