SNP information rs599839

Research and publications:

  17634449   Genomewide association analysis of coronary artery disease.

  18179892   Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

  18193044   Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

  18262040   LDL-cholesterol concentrations: a genome-wide association study.

  18462017   Mapping the genetic architecture of gene expression in human liver.

  18649068   The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol.

  18852197   Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants

  18979498   The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.

  19065533   [Association of single nucleotide polymorphism rs599839 on chromosome 1p13.3 with premature coronary heart disease in a Chinese Han population].

  19161620   An open access database of genome-wide association results

  19164808   Large scale association analysis of novel genetic loci for coronary artery disease.

  19207022   Genome-wide association studies of coronary artery disease and heart failure: where are we going?

  19380133   Significant impact of chromosomal locus 1p13.3 on serum LDL cholesterol and on angiographically characterized coronary atherosclerosis.

  19487539   Large scale replication analysis of loci associated with lipid concentrations in a Japanese population.

  19656773   A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

  19660754   Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.

  19679263   Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.

  19750184   Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

  19802338   Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replicatio

  19837406   Association of the single nucleotide polymorphism rs599839 in the vicinity of the sortilin 1 gene with LDL and triglyceride metabolism, coronary heart disease and myocardial infarction. The Ludwigshafen Risk and Cardiovascular Health Study.

  19913121   Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip

  19924713   Use of longitudinal data in genetic studies in the genome-wide association studies era: summary of Group 14.

  19951432   Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease

  19955471   Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study.

  20017982   Genome-wide association analysis of cardiovascular-related quantitative traits in the Framingham Heart Study.

  20017983   Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.

  20018038   Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study.

  20098575   Genetics and cardiovascular disease: Design and development of a DNA biobank.

  20159871   Association between a literature-based genetic risk score and cardiovascular events in women

  20370913   Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.

  20440292   Early identification of cardiovascular risk using genomics and proteomics.

  20442857   Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.

  20549515   Genome-wide searching of rare genetic variants in WTCCC data.

  20686566   From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.

  20691829   Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.

  20694560   Common genetic polymorphisms in moyamoya and atherosclerotic disease in Europeans.

  20941391   Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study

  20981302   Genome-wide association study of coronary artery disease.

  21087763   Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.

  21103364   Multi-locus test conditional on confirmed effects leads to increased power in genome-wide association studies.

  21242481   Genetic risk score and risk of myocardial infarction in Hispanics.

  21369780   Genome-wide association studies in atherosclerosis.

  21378990   Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

  21463265   Association of SNP rs17465637 on chromosome 1q41 and rs599839 on 1p13.3 with myocardial infarction in an American caucasian population.

  21606135   A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.

  21637794   Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue.

  21698238   Replication of putative susceptibility loci from genome-wide association studies associated with coronary atherosclerosis in Chinese Han population.

  21738485   Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.

  21804106   Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

  21829380   Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability.

  21860704   Implications of discoveries from genome-wide association studies in current cardiovascular practice.

  21862702   Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk.

  21875899   Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour.

  21984477   Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in established coronary artery disease.

  22003152   Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.

  22042884   Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.

  22110658   Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population.

  22144573   Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.

  22151179   Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record.

  22380622   The lp13.3 genomic region -rs599839- is associated with endothelial dysfunction in patients with rheumatoid arthritis.

  22513132   Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study.

  22588700   Genetics of coronary artery disease in the 21st century.

  22623978   A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides.

  22927710   Genetic markers of cardiovascular disease in rheumatoid arthritis.

  22972380   Investigation of genetic risk factors for chronic adult diseases for association with preterm birth

  23024462   Atherosclerosis and rheumatoid arthritis: more than a simple association.

  23067240   Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels.

  23166616   Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients.

  23236363   Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect.

  23404648   An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease.

  23468967   Improvement in prediction of coronary heart disease risk over conventional risk factors using SNPs identified in genome-wide association studies.

  23535823   A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm.

  23964269   The regulated secretory pathway and human disease: insights from gene variants and single nucleotide polymorphisms.

  24251769   LDL-c-linked SNPs are associated with LDL-c and myocardial infarction despite lipid-lowering therapy in patients with established vascular disease.

  24725463   Analysis of common and coding variants with cardiovascular disease in the Diabetes Heart Study.

  24728607   Genetic variants in loci 1p13 and 9p21 and fatal coronary heart disease in a Norwegian case-cohort study.

  24834361   Update on abdominal aortic aneurysm research: from clinical to genetic studies.

  24932356   Genetics of coronary artery disease: an update.

  25469260   Association of a transcription factor 21 gene polymorphism with hypertension.

  25542012   Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.

  25738804   Association of six genetic variants with myocardial infarction.

  26209006   Associations of lipid levels susceptibility loci with coronary artery disease in Chinese population.

  26238946   Association of genetic variants with dyslipidemia.

  26252781   Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11.

  26345841   Association between 1p13.3 genomic markers and coronary artery disease: a meta-analysis involving patients and controls.

  26375028   Genetic Contribution of Variants near SORT1 and APOE on LDL Cholesterol Independent of Obesity in Children.

  26405538   Association of FURIN and ZPR1 polymorphisms with metabolic syndrome.

  26464717   Association of variants in CELSR2-PSRC1-SORT1 with risk of serum lipid traits, coronary artery disease and ischemic stroke.

  26751575   Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure.

  26776183   INTEGRATING CLINICAL LABORATORY MEASURES AND ICD-9 CODE DIAGNOSES IN PHENOME-WIDE ASSOCIATION STUDIES.

  26839654   Genetics of coronary artery disease and myocardial infarction.

  26847647   Experimental Biology for the Identification of Causal Pathways in Atherosclerosis.

  26892960   From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease.

  26958643   Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis.

  26971241   Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans.

  27112212   Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II.

  27189168   The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease.

  27313952   The Impact of Evolutionary Driving Forces on Human Complex Diseases: A Population Genetics Approach.

  27386434   Zinc Finger 259 Gene Polymorphism rs964184 is Associated with Serum Triglyceride Levels and Metabolic Syndrome.

  27418160   Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.