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SNP information rs10757274

Normal allele: AA

A genetic variant on chromosome 9p21 is the strongest genetic predictor of early myocardial infarction (heart attack) found so far. SNPs in this region are also associated with an increased risk of stroke, abdominal aortic aneurysm (AAA) and intracranial aneurysm.

Polymorphism rs10757274 is related to topics like this:

Myocardial infarction
Ischemic heart disease


Research and publications:

  17767904   Genetic and genomic insights into the molecular basis of atherosclerosis.

  18048766   Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease.

  18066490   Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population.

  18250146   Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men.

  18362232   Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease.

  18443000   Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study.

  18505420   Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest).

  18599554   Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.

  18620593   Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome.

  18704761   Molecular genetics of myocardial infarction.

  18925945   Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study.

  18957718   Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population.

  18987759   Genetic testing for atherosclerosis risk: inevitability or pipe dream?

  19019192   Association of genetic variation on chromosome 9p21.3 and arterial stiffness.

  19153409   Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3.

  19171343   Lack of association of chromosome 9p21.3 genotype with cardiovascular structure and function in persons with stable coronary artery disease: The Heart and Soul Study.

  19207022   Genome-wide association studies of coronary artery disease and heart failure: where are we going?

  19214202   Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis.

  19319159   Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke.

  19329499   A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study.

  19559344   Genetic variants on chromosome 9p21 and ischemic stroke in Chinese.

  19750184   Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

  19752551   Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry.

  19888323   Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants.

  19901189   A common variant at 9p21 is associated with sudden and arrhythmic cardiac death.

  19956433   Genetics of coronary artery disease: focus on genome-wide association studies.

  19956784   Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease.

  20031580   Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study.

  20031596   Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the Atherosclerosis Risk in Communities study.

  20075150   Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

  20386740   Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.

  20440292   Early identification of cardiovascular risk using genomics and proteomics.

  20601674   Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study.

  20718794   Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS.

  20981302   Genome-wide association study of coronary artery disease.

  21152093   Sex differential genetic effect of chromosome 9p21 on subclinical atherosclerosis.

  21242481   Genetic risk score and risk of myocardial infarction in Hispanics.

  21369780   Genome-wide association studies in atherosclerosis.

  21372283   Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease.

  21375403   The relationship between polymorphisms on chromosome 9p21 and age of onset of coronary heart disease in black and white women.

  21385355   Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry.

  21444365   Association of a sequence variant in DAB2IP with coronary heart disease.

  21698238   Replication of putative susceptibility loci from genome-wide association studies associated with coronary atherosclerosis in Chinese Han population.

  21705410   The association between variants on chromosome 9p21 and inflammatory biomarkers in ethnically diverse women with coronary heart disease: a pilot study.

  21804106   Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

  21860704   Implications of discoveries from genome-wide association studies in current cardiovascular practice.

  22022235   The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study.

  22034006   Variants on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population.

  22042884   Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.

  22216169   Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery disease.

  22295058   Genetic profiling using genome-wide significant coronary artery disease risk variants does not improve the prediction of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Surv

  22322877   Chromosome 9p21 single nucleotide polymorphisms are not associated with recurrent myocardial infarction in patients with established coronary artery disease.

  22856518   Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21.

  22935634   Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study.

  22975211   Meta-analysis of genetic association of chromosome 9p21 with early-onset coronary artery disease.

  23388737   Association of single nucleotide polymorphisms on chromosome 9p21.3 with cardiovascular death in kidney transplant recipients.

  23535969   Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome.

  24452806   Genetic analysis of the 9p21.3 CAD risk locus in Asian Indians.

  24607648   Genetic variants at chromosome 9p21 and risk of first versus subsequent coronary heart disease events: a systematic review and meta-analysis.

  24676469   Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets.

  24906238   The association of 9p21-3 locus with coronary atherosclerosis: a systematic review and meta-analysis.

  25361584   Subgroups at high risk for ischaemic heart disease:identification and validation in 67 000 individuals from the general population.

  25592106   Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population.

  26708285   A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs.

  26772723   Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men.

  26839654   Genetics of coronary artery disease and myocardial infarction.

  26941057   9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner.

  26944720   Polymorphisms in the long non-coding RNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients.

  26958643   Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis.

  26971241   Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans.

  26982883   Genetics of Coronary Artery Disease in Taiwan: A Cardiometabochip Study by the Taichi Consortium.

  27096864   Chromosome 9p21 and ABCA1 Genetic Variants and Their Interactions on Coronary Heart Disease and Ischemic Stroke in a Chinese Han Population.

  27294088   Genetics of the acute coronary syndrome.

  27539542   Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.

  27716211   A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics.

  27721851   Association of rs10757274 and rs2383206 Polymorphisms on 9p21 locus with Coronary Artery Disease in Turkish Population.

  27846637   Analysis on the Polymorphism of Chromosome Region 9p21 and the Susceptibility of Carotid Plaque.

  28057453   Association of ANRIL gene polymorphisms with major adverse cardiovascular events in hemodialysis patients.

  28243616   Data on genotypic distribution and linkage disequilibrium of several ANRIL polymorphisms in hemodialysis patients.

  28705542   Effect of Coronary Artery Disease risk SNPs on serum cytokine levels and cytokine imbalance in Premature Coronary Artery Disease.

  28813480   Paleogenetic study on the 17th century Korean mummy with atherosclerotic cardiovascular disease.

  28868267   Analysis of Two CDKN2B-AS Polymorphisms in Relation to Coronary Artery Disease Patients in North of Iran.

  29062378   Association between rs10757274 and rs2383206 SNPs as Genetic Risk Factors in Iranian Patients with Coronary Artery Disease.

  29673405   GWAS implicated risk variants in different genes contribute additively to increase the risk of coronary artery disease (CAD) in the Pakistani subjects.

  29791233   Association of a Chromosome Locus 9p21.3 CDKN2B-AS1 Variant rs4977574 with Hypertension: The TAMRISK Study.

  29894795   The role of CDKN2B in cardiovascular risk in ethnic Saudi Arabs: A validation study.

  30065929   Integrating Genes Affecting Coronary Artery Disease in Functional Networks by Multi-OMICs Approach.

  30138332   Genetic variation in 9p21 is associated with fasting insulin in women but not men.

  30387168   Effects of ANRIL polymorphisms on the likelihood of coronary artery disease: A meta-analysis.

  30510472   Evaluation of the role of CDKN2B gene in type 2 diabetes mellitus and hypertension in ethnic Saudi Arabs.

  30558699   Association of CDKN2B-AS1 Polymorphisms with Premature Triple-vessel Coronary Disease and Their Sex Specificity in the Chinese Population.

  30594667   WITHDRAWN: A meta-analysis on associations of CDKN2B-AS variants with atherosclerotic cardio-cerebral vascular diseases.

  30814313   The roles of ANRIL polymorphisms in coronary artery disease: a meta-analysis.

  30962266   Effects of ANRIL variants on the risk of ischemic stroke: a meta-analysis.

  31055994   Genetic variants on chromosome 9p21 confer risks of cerebral infarction in the Chinese population: a meta-analysis.

  31293107   Effect of gene-gene and gene-environment interaction on the risk of first-ever stroke and poststroke death.

  31472045   Common SNP-based haplotype analysis of the 9p21.3 gene locus as predictor coronary artery disease in Tanzanian population.

  32011499   Rs10757274 gene polymorphisms in coronary artery disease: A systematic review and a meta-analysis.

  32248921   9p21.3 coronary artery disease risk locus and interferon alpha 21: Association study in an Asian Indian population.

  32293292   Susceptible gene polymorphism in patients with three-vessel coronary artery disease.

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