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SNP information rs4680

Normal allele: GG

The study showed a 10% increase in total plasma homocysteine (tHcy)

Polymorphism rs4680 is related to topics like this:

DNA methylation genes

The Genetic Methylation Check examines your DNA to offer insights into your unique methylation...

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Approximately 15% of couples of reproductive age are affected by infertility, which is a complex...

Research and publications:

  848488   Inheritance of low erythrocyte catechol-o-methyltransferase activity in man

  7304673   Genetics of red cell COMT activity: analysis of thermal stability and family data

  7585135   The psychobiological regulation of social cooperation

  8807664   Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders

  8886163   Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome

  9110364   Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland

  10395222   Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism

  10459407   Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles

  11171904   The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese

  11381111   Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia

  11502905   Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism

  11772685   Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder

  11925305   A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition

  12192614   Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele

  12359690   Catechol O-methyltransferase genetic polymorphism in panic disorder

  12402217   A highly significant association between a COMT haplotype and schizophrenia

  12436243   Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation

  12595695   COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor

  12611827   Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies

  12716966   Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine

  12802784   A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain

  12842306   A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits

  14966473   Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes

  15098000   COMT haplotypes suggest P2 promoter region relevance for schizophrenia

  15124004   Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families

  15169701   New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis

  15457404   Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain

  15457497   Relationship of MAO-A promoter (u-VNTR) and COMT (V158M) gene polymorphisms to CSF monoamine metabolites levels in a psychiatric sample of caucasians: A preliminary report

  15505638   Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia

  15645182   Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans

  15652872   Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis

  15821730   Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype

  15824744   Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case-control studies

  15931594   An entropy-based statistic for genomewide association studies

  15935994   COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome

  15956988   COMT polymorphisms and anxiety-related personality traits

  16027741   Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease

  16043133   Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations

  16130008   Lack of association of catechol-O-methyltransferase gene Val108/158Met polymorphism with schizophrenia: a family-based association study in a Chinese population

  16135635   No association between schizophrenia and polymorphisms in COMT in two large samples

  16232322   COMT genetic variation confers risk for psychotic and affective disorders: a case control study

  16275815   Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder

  16380905   Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios

  16380908   Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder

  16395295   Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations

  16412218   Multilocus analysis of SNP and metabolic data within a given pathway

  16453988   Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease

  16483362   The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression

  16513880   No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome

  16542388   Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome

  16574089   PCR screening for 22q11.2 microdeletion: development of a new cost-effective diagnostic tool

  16786032   Impact of complex genetic variation in COMT on human brain function

  16816420   Nonlinear tests for genomewide association studies

  16816940   Direct molecular haplotyping of multiple polymorphisms within exon 4 of the human catechol-O-methyltransferase gene by liquid chromatography-electrospray ionization time-of-flight mass spectrometry

  16837108   Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease

  16848906   Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans

  16882734   Genetic predictors for acute experimental cold and heat pain sensitivity in humans

  17006672   Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia

  17116718   Dietary phytoestrogen intake is associated with reduced colorectal cancer risk

  17299513   Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait

  17363961   Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment

  17427186   Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study

  17429315   Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival

  17442488   An association study between cathechol-O-methyltransferase gene and mental retardation in the Chinese Han population

  17466074   Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study

  17482701   No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population

  17483451   Gene-gene interaction associated with neural reward sensitivity

  17504246   Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia

  17504906   The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men

  17548664   Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial

  17604122   A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population

  17630406   Dopamine genes and schizophrenia: case closed or evidence pending?

  17636223   Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata

  17707347   Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls

  17949513   Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS

  17961261   Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia

  17994190   Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults

  18064318   Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk

  18081002   Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials

  18180394   Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans

  18192898   Association of COMT Val108/158Met genotype with smoking cessation

  18196244   Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility

  18213617   Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population

  18235427   Catechol-O-methyltransferase (COMT) val158met genotype is associated with BOLD response as a function of task characteristic

  18324659   COMT polymorphisms affecting protein expression are risk factors for endometrial cancer

  18340529   A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk

  18351593   DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents

  18384078   Association study of candidate variants of COMT with neuroticism, anxiety and depression

  18389087   Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing

  18408230   Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?

  18436194   Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes

  18444252   Neurotransmission and bipolar disorder: a systematic family-based association study

  18466599   Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels

  18466879   Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample

  18486967   A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A)

  18562342   Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia

  18574484   The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase

  18592033   Sex steroid-related candidate genes in psychiatric disorders

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