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SNP information rs1805087

Normal allele: AA

Moderate risk factor for hyperhomocysteinaemia. A factor that increases the body's need for folic acid and vitamin B12.

Polymorphism rs1805087 is related to topics like this:

Vitamin B9 (folic acid)
Vitamin B12
Zinc
Methylation and homocysteine
Varicose veins
Infertility and miscarriage
Vegetarian diet


Research and publications:

  9919998   The frequency of a common mutation of the methionine synthase gene in the Australian population and its relation to smoking and coronary artery disease.

  17035141   Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions

  17119116   Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study

  18098291   Folate metabolism genes, vegetable intake and renal cancer risk in central Europe

  18191955   Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools

  18199722   Dietary vitamin B6 intake and the risk of colorectal cancer

  18203168   Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts

  18381459   Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.

  18521744   BRCA1 promoter methylation is associated with increased mortality among women with breast cancer

  18708404   B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer

  18708408   Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation

  18830263   Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma

  18842806   Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations

  18992148   Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study

  19064578   No association of single nucleotide polymorphisms in one-carbon metabolism genes with prostate cancer risk

  19112534   Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma

  19336559   Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors

  19376481   One-carbon metabolism and breast cancer: an epidemiological perspective

  19493349   118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects

  19525478   Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study.

  19683694   Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida

  19706843   Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk

  19706844   Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis

  19737740   Associations of folate and choline metabolism gene polymorphisms with orofacial clefts.

  19776626   Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk

  19936946   Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer

  20099281   Blood leukocyte DNA hypomethylation and gastric cancer risk in a high-risk Polish population.

  20101025   Genetic variation in the folate metabolic pathway and risk of childhood leukemia

  20111745   Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects

  20490431   5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer.

  20544798   Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women

  20549016   MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer.

  20600216   Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina

  20615890   A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.

  20670920   Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism

  20718043   Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome

  20811316   SLC19A1 pharmacogenomics summary.

  20813848   Plasma vitamins B2, B6, and B12, and related genetic variants as predictors of colorectal cancer risk

  20960050   Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer

  21036793   Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field

  21146954   Genes and abdominal aortic aneurysm

  21178085   High intake of folate from food sources is associated with reduced risk of esophageal cancer in an Australian population

  21204206   Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population

  21254359   Folate pathway and nonsyndromic cleft lip and palate.

  21274745   Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study.

  21349258   Folate and choline metabolism gene variants and development of uterine cervical carcinoma.

  21429654   Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.

  21441680   Profiling single nucleotide polymorphisms (SNPs) across intracellular folate metabolic pathway in healthy Indians.

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21514219   Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence

  21533139   Predicting diabetic nephropathy using a multifactorial genetic model.

  21533266   Data integration workflow for search of disease driving genes and genetic variants.

  21567207   Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.

  21597034   The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults.

  21610500   Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism.

  21615938   Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder.

  21618410   Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy.

  21658613   Host genetics in follicular lymphoma.

  21688148   Polymorphic variants of genes involved in homocysteine metabolism in celiac disease.

  21738611   B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP).

  21747588   Genetic variation in genes involved in folate and drug metabolism in a south Indian population.

  21748308   Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia.

  21857689   Folate and vitamin B12 in idiopathic male infertility.

  21960995   Common variants of homocysteine metabolism pathway genes and risk of type 2 diabetes and related traits in Indians.

  22021659   Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia.

  22116453   Folate and vitamin B12-related genes and risk for omphalocele.

  22183302   Folate and choline metabolism gene variants in relation to ovarian cancer risk in the Polish population.

  22199995   The causal roles of vitamin B(12) and transcobalamin in prostate cancer: can Mendelian randomization analysis provide definitive answers?

  22371529   DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study.

  22496743   Genetic variant of AMD1 is associated with obesity in urban Indian children.

  22616673   Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.

  22719222   The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer.

  22792358   Association between genetic variants in DNA and histone methylation and telomere length.

  22833659   Gender and single nucleotide polymorphisms in MTHFR, BHMT, SPTLC1, CRBP2, CETP, and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults.

  22839213   Association of postmenopausal endogenous sex hormones with global methylation level of leukocyte DNA among Japanese women.

  22957669   Association of dietary and genetic factors related to one-carbon metabolism with global methylation level of leukocyte DNA.

  23139751   Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population.

  23294634   Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction.

  23401104   Folate-genetics and colorectal neoplasia: what we know and need to know next.

  23446900   One-carbon metabolism factors and leukocyte telomere length.

  23656756   Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults.

  23940529   Roles of genetic polymorphisms in the folate pathway in childhood acute lymphoblastic leukemia evaluated by Bayesian relevance and effect size analysis.

  23946381   Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence.

  24048206   Neural tube defects, folic acid and methylation.

  24063603   Cancer-testis gene expression is associated with the methylenetetrahydrofolate reductase 677 C>T polymorphism in non-small cell lung carcinoma.

  24103477   Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.

  24130171   Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study.

  24500500   Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism.

  24521996   Genetic variants and multiple myeloma risk: IMMEnSE validation of the best reported associations--an extensive replication of the associations from the candidate gene era.

  24524080   The effect of multiple single nucleotide polymorphisms in the folic acid pathway genes on homocysteine metabolism.

  24534481   Association between TLR2, MTR, MTRR, XPC, TP73, TP53 genetic polymorphisms and gastric cancer: a meta-analysis.

  24748989   Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta-analysis.

  24956146   No association between MTR rs1805087 A > G polymorphism and non-Hodgkin lymphoma susceptibility: evidence from 11 486 subjects.

  24991206   Polymorphisms in folate pathway and pemetrexed treatment outcome in patients with malignant pleural mesothelioma.

  25227144   Folate-related polymorphisms in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.

  25293959   Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.

  25315199   Genetic association and gene expression studies suggest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine.

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