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Vitamin B12 DNA health report

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Vitamin B12 and see a list of existing studies.

SNP polymorphisms related to the topic Vitamin B12:

rs162036Disorders of intracellular metabolism of cobalamin. Positive effect on the efficacy of folic acid therapy in patients with hyperhomocysteinaemia.
rs326124
rs492602B12 levels are 1.5 times higher in women.
rs526934Causes decreased concentrations of vitamin B6, vitamin B12, folic acid and increased homocysteine in the blood.
rs557564
rs601338FUT2 gene fragment affects serum vitamin B12 concentration via hologaptocorrin. Presumably reduces the amount of vitamin B12 absorption from food and tablets. Administration of B12 in the form of injections is recommended.
rs602662The polymorphism is associated with reduced levels of vitamin B12 in the blood, this effect may be due to reduced absorption of vitamin B12, such people need additional vitamin B12 supplementation in the form of injections.
rs703062
rs708686
rs1532268
rs1801133A gene fragment known as MTHFR C677T, which encodes an enzyme involved in folic acid metabolism. A break in this gene fragment results in high levels of homocysteine, low levels of B12 and folic acid. If your tests show high homocysteine levels, your doctor will likely advise you on an appropriate diet and supplementation regime. Taking varieties of the active form of B9 methylfolate (5-MTHF or L-methyltetrahydrofolate), the active form of vitamin B12, methylcobalamin, is recommended to reduce your risks.
rs1801239Hereditary malabsorption of cobalamin. The gene encodes a vitamin B12 receptor factor, cubilin, and causes hereditary megaloblastic anaemia.
rs1801394Polymorphism can lead to elevated homocysteine levels independent of folic acid, vitamin B12 or B6 levels. It is a risk factor for neural tube defects and Down syndrome in the setting of higher homocysteine levels.
rs1805087Moderate risk factor for hyperhomocysteinaemia. A factor that increases the body's need for folic acid and vitamin B12.
rs2283873
rs2287780Polymorphism in folic acid pathway genes causing B12 deficiency and increased homocysteine.
rs3760776Associated with serum vitamin B12 levels in men
rs5749135
rs7703033Causes decreased concentrations of vitamin B6, vitamin B12, folic acid and increased homocysteine in the blood.
rs9606756Polymorphism associated with serum levels of vitamin B12. Also associated with transcobalamin concentrations in pregnant women and risk of neural tube defects in the foetus.
rs10064631Methionine synthase deficiency, impairing the metabolism of folic acid B9 and cobalamin B12.
rs10925257A marker of vitamin B12 deficiency and frailty in older women.
rs10925263Disorders of intracellular metabolism of cobalamin.
rs11254363Causes decreased concentrations of vitamin B6, vitamin B12, folic acid and increased homocysteine in the blood.
rs16982241FUT2 gene fragment affects serum vitamin B12 concentration via hologaptocorrin. Presumably reduces the amount of vitamin B12 absorption from food and tablets. Administration of B12 in the form of injections is recommended.
rs34324219Transcobalamin deficiency.
rs117699377
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