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SNP information rs602662

Normal allele: AA

The polymorphism is associated with reduced levels of vitamin B12 in the blood, this effect may be due to reduced absorption of vitamin B12, such people need additional vitamin B12 supplementation in the form of injections.

Polymorphism rs602662 is related to topics like this:

Vitamin B12
Vegetarian diet

Research and publications:

  18776911   Common variants of FUT2 are associated with plasma vitamin B12 levels.

  18997004   Widespread balancing selection and pathogen-driven selection at blood group antigen genes.

  19303062   Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.

  19744961   Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.

  20574445   A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis.

  20971884   Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium.

  21115529   Genetics and genomics of human ageing.

  21507254   Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease.

  22025780   FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection.

  22393410   Loss and gain of function in SERPINB11: an example of a gene under selection on standing variation, with implications for host-pathogen interactions.

  22521342   Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.

  23201895   Common variant in FUT2 gene is associated with levels of vitamin B(12) in Indian population.

  26646561   Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk.

  27535653   eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants.

  27901035   Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample Mendelian randomization analysis.

  27995393   Genetic determinants of serum vitamin B12 and their relation to body mass index.

  28334792   GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians.

  28824326   FUT2 genetic variants as predictors of tumor development with hepatocellular carcinoma.

  30376117   FUT2 Genetic Variants and Reported Respiratory and Gastrointestinal Illnesses During Infancy.

  30888520   Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

  31483113   GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract.

  33170161   Genetic test for the prescription of diets in support of physical activity.

  33763108   Whole Genome Interpretation for a Family of Five.

  34308116   Genetic factors associated with obesity risks in a Kazakhstani population.

  34491321   The Effect of Phenotype and Genotype on the Plasma Proteome in Patients with Inflammatory Bowel Disease.