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SNP information rs4633

Normal allele: CC

Catechol-O-methyltransferase deficiency is associated with total plasma homocysteine levels and may increase the risk of venous thrombosis.

Polymorphism rs4633 is related to topics like this:

DNA methylation genes

The Genetic Methylation Check examines your DNA to offer insights into your unique methylation...

The membrane-bound protein called the dopamine transporter (DAT), also known as the...


Research and publications:

  12802784   A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain

  15505638   Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia

  16380905   Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios

  16848906   Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans

  16882734   Genetic predictors for acute experimental cold and heat pain sensitivity in humans

  17363961   Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment

  17961261   Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia

  18064318   Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk

  18324659   COMT polymorphisms affecting protein expression are risk factors for endometrial cancer

  18389087   Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing

  18574484   The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase

  18663369   Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR).

  18698231   Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

  18802928   Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.

  19015200   Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.

  19094200   Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.

  19159868   Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia.

  19168589   Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.

  19290789   Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment.

  19365560   Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.

  19693267   Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

  19772600   A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data.

  19852950   The association of catechol-O-methyltransferase genotype with the phenotype of women with eating disorders.

  20083391   A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry.

  20483479   Analysis of association between the catechol-O-methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia.

  20531207   The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.

  20551675   Localizing putative markers in genetic association studies by incorporating linkage disequilibrium into bayesian hierarchical models.

  20570835   No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain.

  20627703   The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.

  20667552   Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.

  20863768   Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.

  20877297   Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response.

  21107304   Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation.

  21289622   Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.

  21300128   COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa.

  21304959   Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.

  21423693   Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.

  21462137   [An association study of COMT gene polymorphisms with schizophrenia].

  21527290   Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood.

  21570824   Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids.

  21680027   Influence and interaction of genetic polymorphisms in catecholamine neurotransmitter systems and early life stress on antidepressant drug response.

  21708280   Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis

  21905019   Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia.

  21940152   The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder--a European multicenter study.

  22105624   The genetics of attention deficit/hyperactivity disorder in adults, a review.

  22178088   Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome.

  22253202   Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population.

  22451510   Catechol-o-methyltransferase gene and executive function in children with ADHD.

  22528689   Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene.

  22701660   Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-GuĂ©rin.

  22939719   Oxytocin and catechol-O-methyltransferase receptor genotype predict the length of the first stage of labor.

  23209597   Investigating the genetic basis of theory of mind (ToM): the role of catechol-O-methyltransferase (COMT) gene polymorphisms.

  23766564   Pharmacogenetics of chronic pain and its treatment.

  23922910   A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk.

  23963787   Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.

  24178190   Influence of variation in the catechol-O-methyltransferase gene on the clinical outcome after lumbar spine surgery for one-level symptomatic disc disease: a report on 176 cases.

  24448899   Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype.

  24491308   Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men.

  24755993   Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences?

  24782743   Association of COMT and COMT-DRD2 interaction with creative potential.

  24881125   From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment.

  24904231   A novel catechol-O-methyltransferase variant associated with human disc degeneration.

  25040948   The design and methods of genetic studies on acute and chronic postoperative pain in patients after total knee replacement.

  25218601   Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.

  25324626   Research in China on the molecular genetics of schizophrenia.

  25532715   COMT gene haplotypes are closely associated with postoperative fentanyl dose in patients.

  25599448   Association of functional variations in COMT and GCH1 genes with postherniotomy pain and related impairment.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25772090   Catechol-O-methyltransferase (COMT) gene polymorphisms are associated with baseline disability but not long-term treatment outcome in patients with chronic low back pain.

  25963335   Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy.

  26483654   Linking unfounded beliefs to genetic dopamine availability.

  26516523   Pharmacogenetics of analgesic drugs.

  26724569   Catechol-O-methyltransferase gene variants may associate with negative symptom response and plasma concentrations of prolactin in schizophrenia after amisulpride treatment.

  26808641   Dopamine receptor D2 and catechol-O-methyltransferase gene polymorphisms associated with anorexia nervosa in Chinese Han population: DRD2 and COMT gene polymorphisms were associated with AN.

  26849490   Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.

  26988620   No associations between five polymorphisms in COMT gene and migraine.

  27028297   A Complex Systems Approach to Causal Discovery in Psychiatry.

  27282867   Catechol-O-methyltransferase association with hemoglobin A1c.

  27636225   An Expert Review of Pharmacogenomics of Sickle Cell Disease Therapeutics: Not Yet Ready for Global Precision Medicine.

  27903758   OPRM1 and COMT Gene-Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma.

  27917384   Genetic Alterations in Intervertebral Disc Disease.

  28652652   Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.

  28822116   Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.

  29195501   COMT genotype and non-recovery after a whiplash injury in a Northern European population.

  29330410   The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.

  29331705   Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: A prospective birth cohort study.

  29559808   Association of genetic variation in COMT gene with pain related to sickle cell disease in patients from the walk-PHaSST study.

  29692704   Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults.

  29760667   A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese.

  29912452   Genetic Predictors of Response to Acupuncture for Aromatase Inhibitor-Associated Arthralgia Among Breast Cancer Survivors.

  30158547   A common polymorphism of COMT was associated with symptomatic lumbar disc herniation based on a large sample with Chinese Han ancestry.

  30453067   Association of genetic polymorphisms with age at menarche in Russian women.

  30597299   A gender-specific COMT haplotype contributes to risk modulation rather than disease severity of major depressive disorder in a Chinese population.

Calcium score report

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Choline mthfr

Choline (vitaman B4) is a vital nutrient often lacking in many diets. Indeed, a large portion of...

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