SNP information rs12325817

Research and publications:

  16816108   Common genetic polymorphisms affect the human requirement for the nutrient choline.

  17613168   Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline.

  17616785   Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not.

  18230680   Choline metabolism and risk of breast cancer in a population-based study.

  18789905   Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models.

  19116320   Importance of methyl donors during reproduction.

  19167960   Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.

  19261726   Epigenetic mechanisms for nutrition determinants of later health outcomes.

  20436254   Choline: clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements.

  20662904   Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.

  20861172   Dietary choline requirements of women: effects of estrogen and genetic variation.

  21059658   Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.

  21411618   Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans.

  21857689   Folate and vitamin B12 in idiopathic male infertility.

  22116453   Folate and vitamin B12-related genes and risk for omphalocele.

  22303299   A grand challenge for nutrigenomics.

  22371529   DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study.

  23794489   Higher homocysteine and lower betaine increase the risk of microangiopathy in patients with diabetes mellitus carrying the GG genotype of PEMT G774C.

  25921832   Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.

  26728177   Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents.

  27677362   Choline metabolic pathway gene polymorphisms and risk for Down syndrome: An association study in a population with folate-homocysteine metabolic impairment.

  30055775   PEMT rs12325817 and PCYT1A rs7639752 polymorphisms are associated with betaine but not choline concentrations in pregnant women.

  30321787   Importance of polymorphic variants of phosphatidylethanolamine N-methyltransferase (PEMT) gene in the etiology of intrauterine fetal death in the Polish population.

  31044529   Associations between folate and choline intake, homocysteine metabolism, and genetic polymorphism of MTHFR, BHMT and PEMT in healthy pregnant Polish women.

  33170161   Genetic test for the prescription of diets in support of physical activity.

  34217074   Resolution of severe hepatosteatosis in a cystic fibrosis patient with multifactorial choline deficiency: A case report.

  34233321   Comparison of Associations between One-Carbon Metabolism, Lipid Metabolism, and Fatty Liver Markers in Normal-Weight and Overweight People Aged 20-40 Years.

  35668704   Associations of plasma betaine, plasma choline, choline intake, and MTHFR polymorphism (rs1801133) with anthropometric parameters of healthy adults are sex-dependent.