Normal allele: TT
The fatty acid desaturase (FADS) gene polymorphism is associated with insulin resistance, type 2 diabetes and impaired fasting glucose levels in adults.
Polymorphism rs174550 is related to topics like this:
Omega-3, unsaturated fatty acids
Research and publications:
20081858 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
20185807 Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans
20693352 Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies
20805255 Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult population
20870969 Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study
20886378 Physiologic characterization of type 2 diabetes-related loci
21091714 The genetics of type 2 diabetes: what have we learned from GWAS?
21103350 Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese
21421807 Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men
21513558 Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study.
21515849 Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children
21747906 Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans.
21810599 Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis
21848424 Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States.
21887289 Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin
21949744 Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes
22984506 Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program
23013243 Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children
23073174 From genotype to human β cell phenotype and beyond
23185617 Genetic variant SLC2A2 [corrected] Is associated with risk of cardiovascular disease – assessing the individual and cumulative effect of 46 type 2 diabetes related genetic variants
23396965 Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans.
25073516 Meta-analysis of genome-wide association study of homeostasis model assessment β cell function and insulin resistance in an East Asian population and the European results.
25774817 Genetics of type 2 diabetes-pitfalls and possibilities.
25930966 Longitudinal associations of serum fatty acid composition with type 2 diabetes risk and markers of insulin secretion and sensitivity in the Finnish Diabetes Prevention Study.
26501394 Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men.
27353450 The genetic regulatory signature of type 2 diabetes in human skeletal muscle.
27383215 Type 2 Diabetes Risk Allele Loci in the Qatari Population.
27782183 Evaluating the transferability of 15 European-derived fasting plasma glucose SNPs in Mexican children and adolescents.
28084440 Common risk variants for colorectal cancer: an evaluation of associations with age at cancer onset.
28359772 GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 Gene Polymorphisms in Women with Gestational Diabetes.
28555039 FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.
28729637 Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes.
29847832 Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study.
30624587 Inflammatory response to dietary linoleic acid depends on FADS1 genotype.
31299695 Common Type 2 Diabetes Genetic Risk Variants Improve the Prediction of Gestational Diabetes.
31991592 Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome.
33548080 The FADS1 Genotype Modifies Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2.
34718859 FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study.
35351696 Empowering consumers to PREVENT diet-related diseases through OMICS sciences (PREVENTOMICS): protocol for a parallel double-blinded randomised intervention trial to investigate biomarker-based nutrition plans for weight loss.
35701670 The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism.
35871074 Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study.