SNP information rs174546

Research and publications:

  19060910   Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

  19148276   Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.

  19798445   Genetic determinants of circulating sphingolipid concentrations in European populations.

  20427696   Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.

  20484448   Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study.

  20562440   FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

  20565855   Genetic variation in lipid desaturases and its impact on the development of human disease.

  20691134   Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.

  20694148   A genome-wide association study of the metabolic syndrome in Indian Asian men.

  20833654   Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes.

  20948998   Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.

  21041806   Genetic determinants of plasma triglycerides.

  21091714   The genetics of type 2 diabetes: what have we learned from GWAS?

  21527746   Triglycerides and heart disease: still a hypothesis?

  21593353   FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents.

  21597005   An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.

  21599946   The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans.

  21733300   Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.

  21767357   Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome.

  21793953   FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children.

  21818279   Influence of FADS polymorphisms on tracking of serum glycerophospholipid fatty acid concentrations and percentage composition in children.

  21829377   Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

  21860704   Implications of discoveries from genome-wide association studies in current cardiovascular practice.

  22073310   Association of genetic loci with blood lipids in the Chinese population.

  22194195   Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms.

  22567092   MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS.

  22629455   FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies.

  22701466   Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos.

  22900039   Age and haplotype variations within FADS1 interact and associate with alterations in fatty acid composition in human male cortical brain tissue.

  24853887   Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases.

  24879641   Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families.

  24890013   Genetic predisposition scores for dyslipidaemia influence plasma lipid concentrations at baseline, but not the changes after controlled intake of n-3 polyunsaturated fatty acids.

  24918908   Genomic and metabolomic profile associated to microalbuminuria.

  25008580   Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease.

  25367143   Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation.

  26346302   Predicting fatty acid profiles in blood based on food intake and the FADS1 rs174546 SNP.

  26446360   Mendelian randomization studies of biomarkers and type 2 diabetes.

  26595274   Genome-wide patterns of selection in 230 ancient Eurasians.

  26891335   Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype.

  27004414   Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.

  27073872   Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms.

  27286809   Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

  28283271   Multiple chemical sensitivity: Genotypic characterization, nutritional status and quality of life in 52 patients.

  28333262   Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes.

  28577571   Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.

  28598979   Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up.

  28732058   The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models.

  28732532   GATE: an efficient procedure in study of pleiotropic genetic associations.

  28821713   Evaluating the Causal Relation of ApoA-IV with Disease-Related Traits - A Bidirectional Two-sample Mendelian Randomization Study.

  28929400   Can polymorphisms in the fatty acid desaturase (FADS) gene cluster alter the effects of fish oil supplementation on plasma and erythrocyte fatty acid profiles? An exploratory study.

  29491470   Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population.

  29722844   Joint effects of fatty acid desaturase 1 polymorphisms and dietary polyunsaturated fatty acid intake on circulating fatty acid proportions.

  29847832   Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study.

  29878044   Long-chain polyunsaturated fatty acids, gestation duration, and birth size: a Mendelian randomization study using fatty acid desaturase variants.

  29989339   Association of low-density lipoprotein receptor-related protein 1 rs11613352 and angiopoietin-like 3 rs2131925 with hypertension in men-the Tampere adult population cardiovascular risk study.

  30065929   Integrating Genes Affecting Coronary Artery Disease in Functional Networks by Multi-OMICs Approach.

  30082751   FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression.

  31991592   Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome.

  32502762   FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women.

  32622152   Metabolic syndrome in postmenopausal women is associated with lower erythrocyte PUFA/MUFA and n-3/n-6 ratio: A case-control study.

  33073494   An in silico approach to identify and prioritize miRNAs target sites polymorphisms in colorectal cancer and obesity.

  34189740   FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents.

  35379196   Analysis of 61 SNPs from the CAD specific genomic loci reveals unique set of SNPs as significant markers in the Southern Indian population of Hyderabad.

  35387194   Personalized Dietary Recommendations Based on Lipid-Related Genetic Variants: A Systematic Review.