SNP information rs174575

Research and publications:

  18936223   Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation.

  20335541   FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk.

  20395685   Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study.

  20562440   FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

  20565855   Genetic variation in lipid desaturases and its impact on the development of human disease.

  21040914   FADS gene polymorphisms in Koreans: association with ω6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease.

  21156270   Cognitive function in adolescence: testing for interactions between breast-feeding and FADS2 polymorphisms.

  21513558   Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study.

  21793953   FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children.

  22194195   Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms.

  22629455   FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies.

  23636240   FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants.

  23737301   A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems.

  24643342   Effects on metabolic markers are modified by PPARG2 and COX2 polymorphisms in infants randomized to fish oil.

  25080457   FADS single-nucleotide polymorphisms are associated with behavioral outcomes in children, and the effect varies between sexes and is dependent on PPAR genotype.

  26439440   Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part I: maternal FADS2 genotype and DNA methylation correlate with polyunsaturated fatty acid status in toddlers: an exploratory analysis.

  26455892   Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance.

  26474818   Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.

  26742060   DHA Effects in Brain Development and Function.

  26891335   Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype.

  26950146   Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes.

  27188529   Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic Acid.

  28162103   A study of associations between early DHA status and fatty acid desaturase (FADS) SNP and developmental outcomes in children of obese mothers.

  28237083   Association of the FADS gene cluster with coronary artery disease and plasma lipid concentrations in the northern Chinese Han population.

  28259851   Study protocol to investigate the environmental and genetic aetiology of atopic dermatitis: the Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI).

  28552045   Erythrocyte polyunsaturated fatty acid composition is associated with depression and FADS genotype in Caucasians.

  28555039   FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.

  30050886   Association of Polymorphism in Fatty Acid Desaturase Gene with the Risk of Type 2 Diabetes in Iranian Population.

  30541029   Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis.

  31568926   Maternal polymorphisms in the FADS1 and FADS2 genes modify the association between PUFA ingestion and plasma concentrations of omega-3 polyunsaturated fatty acids.

  31589250   Human milk fatty acid composition is associated with dietary, genetic, sociodemographic, and environmental factors in the CHILD Cohort Study.

  32127356   Risk SNP-Mediated Enhancer-Promoter Interaction Drives Colorectal Cancer through Both FADS2 and AP002754.2.

  32127447   Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease.

  32433731   Maternal Long-Chain Polyunsaturated Fatty Acid Status, Methylmercury Exposure, and Birth Outcomes in a High-Fish-Eating Mother-Child Cohort.

  33526157   Maternal and child fatty acid desaturase genotype as determinants of cord blood long-chain PUFA (LCPUFA) concentrations in the Seychelles Child Development Study.

  34394238   Association of FADS2 rs174575 gene polymorphism and insulin resistance in type 2 diabetes mellitus.

  34543890   Maternal FADS2 single nucleotide polymorphism modified the impact of prenatal docosahexaenoic acid (DHA) supplementation on child neurodevelopment at 5 years: Follow-up of a randomized clinical trial.