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SNP information rs1535

Normal allele: AA

FADS2 polymorphisms affect blood levels of omega-3 and omega-6 polyunsaturated fatty acids during pregnancy, at birth, and at age 7 years.

Polymorphism rs1535 is related to topics like this:

Omega 3 genetics

It may seem counterintuitive that substances with the names "fat" and "acid" can be beneficial for...


Research and publications:

  19060910   Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

  19798445   Genetic determinants of circulating sphingolipid concentrations in European populations.

  20694148   A genome-wide association study of the metabolic syndrome in Indian Asian men.

  21347282   Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

  21421807   Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men

  21599946   The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans.

  21733300   Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.

  21829377   Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

  22073310   Association of genetic loci with blood lipids in the Chinese population.

  22194195   Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms.

  22629316   Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

  22701466   Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos.

  22743310   Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study.

  23636240   FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants.

  23737301   A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems.

  24643342   Effects on metabolic markers are modified by PPARG2 and COX2 polymorphisms in infants randomized to fish oil.

  25080457   FADS single-nucleotide polymorphisms are associated with behavioral outcomes in children, and the effect varies between sexes and is dependent on PPAR genotype.

  25884002   Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols.

  26742060   DHA Effects in Brain Development and Function.

  26879377   FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome.

  26891335   Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype.

  26950146   Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes.

  27188529   Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic Acid.

  27207650   Genome-wide association study of colorectal cancer in Hispanics.

  28084440   Common risk variants for colorectal cancer: an evaluation of associations with age at cancer onset.

  28162103   A study of associations between early DHA status and fatty acid desaturase (FADS) SNP and developmental outcomes in children of obese mothers.

  28506205   In silico pathway analysis and tissue specific cis-eQTL for colorectal cancer GWAS risk variants.

  28515069   Mendelian randomization shows sex-specific associations between long-chain PUFA-related genotypes and cognitive performance in Danish schoolchildren.

  28598979   Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up.

  29847832   Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study.

  30541029   Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis.

  31050749   FADS and PPARG2 Single Nucleotide Polymorphisms are Associated with Plasma Lipids in 9-Mo-Old Infants.

  31532795   Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction-Post-hoc analysis from the OMEGA-REMODEL randomized controlle

  31991592   Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome.

  32093185   FADS Genetic Variants in Taiwanese Modify Association of DHA Intake and Its Proportions in Human Milk.

  32713352   Does polymorphisms in PPAR and APOE genes modify associations between fatty acid desaturase (FADS), n-3 long-chain PUFA and cardiometabolic markers in 8-11-year-old Danish children?

  33193614   The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study.

  33509958   Intake of n-3 polyunsaturated fatty acids in childhood, FADS genotype and incident asthma.

  35906330   FADS cluster variants are associated with insulin sensitivity in children and adolescents with overweight and obesity.

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