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SNP information rs1799913

RS1799913

Normal allele: GG

Variants in the tryptophan hydroxylase gene involved in the development and treatment of opiate, heroin and cocaine addiction.

Polymorphism rs1799913 is related to topics like this:

Serotonin transporter sert

In humans, the SLC6A4 gene encodes a protein referred to as both the sodium-dependent serotonin...

Is OCD obsessive compulsive disorder genetic

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by features known as...

Depression is it genetic

Depression, also referred to as major depression or major depressive disorder, is a psychiatric...

Is drug abuse genetic

There is a significant interest among individuals, particularly those with a familial background of...


Research and publications:

  17521439   Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach.

  18181017   TPH2 and TPH1: association of variants and interactions with heroin addiction.

  20201854   Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.

  20580984   Tryptophan hydroxylase gene 1 (TPH1) variants associated with cerebrospinal fluid 5-hydroxyindole acetic acid and homovanillic acid concentrations in healthy volunteers.

  21073637   Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome.

  21333900   The role of genetics in IBS

  21711518   Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms.

  22650965   Paradox of schizophrenia genetics: is a paradigm shift occurring?

  22933845   Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse.

  25005534   Association of TPH-1 and TPH-2 gene polymorphisms with suicidal behavior: a systematic review and meta-analysis.

  25073638   Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis.

  26227246   Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry.

  26710093   Tryptophan hydroxylase 1 gene polymorphisms alter prefrontal cortex activation during response inhibition.

  27521242   TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.

  27573591   Personality traits as an endophenotype in genetic studies on suicidality in bipolar disorder.

  27895608   Genetic Consideration of Schizotypal Traits: A Review.

  28590957   Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes.

  29314569   Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.

  30602107   Gray Matter Volume Reductions Were Associated with TPH1 Polymorphisms in Depressive Disorder Patients with Suicidal Attempts.

  30789538   Association of polymorphisms in HTR2A, TPH1, and TPH2 genes with attempted suicide in rural China.

  30923939   Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study.

  31817010   Variation of Genes Encoding Tryptophan Catabolites Pathway Enzymes in Stroke.

  35040003   Identification of putative genetic variants in major depressive disorder patients in Pakistan.

  35928776   Association between TPH1 polymorphisms and the risk of suicide behavior: An updated meta-analysis of 18,398 individuals.

CYP21 deficiency

The inability to synthesize cortisol, known as congenital adrenal hyperplasia (CAH), is responsible...

Dopamine transporter genes

The membrane-bound protein called the dopamine transporter (DAT), also known as the...

Mitochondria dna

The mitochondria contain circular chromosomes known as mitochondrial DNA and are organelles...

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