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Serotonin transporter sert

serotonin

By Li Dali, Ph.D.

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In humans, the SLC6A4 gene encodes a protein referred to as both the sodium-dependent serotonin transporter and solute carrier family 6 member 4. This protein is commonly known as the serotonin transporter.

The study of genetic variation can help us understand how behavioral diversity evolves and persists. Genes in the serotonin signaling pathway, like SERT, may impact animal personality, cognition, and fitness. To explore this relationship further in great tits (Parus major), we examined how variations in SERT polymorphisms might be related to neophobia, exploratory behavior performance during obstacle removal tests at their nest boxes or laying date as well as problem-solving abilities measured by single nucleotide polymorphism testing for birds. We found some indications that certain SNPs were connected to these behaviors such as more successful attempts when homozygous AA minor alleles carried exon 1 SNP226 vs higher chances among both sexes but most notably females who had CCs on Exon 9's exchange location- all exhibiting positive relationships though statistically significant results only appeared once corrected from multiple comparisons made. This research lays a strong foundation for future studies assessing the role genetics play regarding cognitive differences amongst wild animals populations.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Serotonin and see a list of existing studies.

SNP polymorphisms related to the topic Serotonin:

rs1799913Variants in the tryptophan hydroxylase gene involved in the development and treatment of opiate, heroin and cocaine addiction.
rs1386494TPH2 gene polymorphism increases the risk and magnitude of depressive disorder.
rs6313TPH-2 polymorphisms affect response to treatment with antidepressants and SSRIs.
rs4570625The TPH2 gene variant is associated with attention-deficit/hyperactivity disorder.
rs1042173The serotonin transporter gene SLC6A4 is associated with premenopausal and perimenopausal hot flashes and headache.
rs6314The serotonin receptor gene HTR2A polymorphism is associated with bipolar affective disorder and autism spectrum disorder.
rs2276302The HTR3B gene is associated with alcoholism with antisocial behaviour.
rs17110563The gene breakage is linked to bipolar affective disorder.
rs6295The 5-HT1A gene polymorphism increases the risk and magnitude of depressive disorder.
rs6305Serotonin transporter and serotonin receptor gene polymorphisms are associated with susceptibility to substance abuse.
rs3742278Serotonin receptor gene HTR2A polymorphism is associated with panic disorder features.
rs7984966Serotonin receptor gene HTR2A polymorphism as a possible predisposing factor for aggressive traits.
rs1928040Polymorphisms of the gene encoding serotonin 2A receptor affect response to antidepressant treatment.
rs9316233Polymorphisms of the gene encoding serotonin 2A receptor affect response to antidepressant treatment.
rs878567HTR1A serotonin receptor gene polymorphism is associated with neuroticism, major depression and anxiety disorders.
rs1328674Genetic variations in the serotonin 5-HT2A receptor gene are associated with rheumatoid arthritis.
rs6311Genetic factors specific to obsessive-compulsive disorder.
rs17722134Gene modification affects the severity of ADHD.
rs11568817Functional polymorphisms in the serotonin receptor gene HTR1B predict increased anger and hostility.
rs1062613Fear reactivation and symptoms of combat-related PTSD: specificity and preliminary study of the effect of the 5-HT3A receptor gene.
rs1176713Common variants of the HTR3 gene are associated with obsessive-compulsive disorder.
rs9325202Breakage of the tryptophan hydroxylase gene promotes dishonest behaviour.
rs1843809Breakage of the tryptophan hydroxylase 2 (TPH2) gene associated with attention deficit hyperactivity disorder.
rs7997012Associations of the serotonin receptor gene HTR2A with bipolar disorder and major depressive disorder.
rs7224199Association with major depression and response to antidepressants. The polymorphism is associated with selective serotonin and serotonin-norepinephrine reuptake inhibitor response in depressive disorder.
rs140700A variant of the serotonin transporter gene (SLC6A4) is associated with suicidal behaviour in schizophrenic patients.
rs2020933A serotonin transporter gene whose function affects all cellular serotonin systems.
rs1487278A polymorphism in the tetrahydrobiopterin pathway gene is associated with an increased risk of autism.
rs28914829A polymorphism in the serotonin transporter locus (SLC6A4) predisposes to autism and compulsive rigid behaviour.
rs2066713A functional serotonin transporter gene polymorphism is associated with major depression, schizophrenia and ADHD.
rs9567737
rs9567746
rs6312
rs1805055
rs7330636
rs12583882
rs11077820
rs56232120
rs35815285
rs11604247
rs17288723
rs10879346
rs2129785
rs4565946
rs11179003
rs10748189
rs6296
rs11867581
rs211107
rs1386488
rs201779669
rs147198243
rs145278314
rs34550504
rs200889198
rs61907889
rs79874540
rs12805047
rs118187155
rs114014601
rs35201864
rs79779791
rs146411553
rs1549339
rs2276307
rs146375175
rs76303657
rs45570136
rs676643
rs130060
rs17706602
rs7725785
rs78932366
rs11657536
rs9316232
rs2224721

About The Author
Li Dali Li Dali

Li Dali, a National Foundation for Outstanding Youth Fund recipient, is a researcher at the School of Life Sciences in East China Normal University. He earned his PhD in genetics from Hunan Normal University in 2007 and conducted collaborative research at Texas A&M University during his doctoral studies. Li Dali and his team have optimized and innovated gene editing technology, leading to the establishment of a world-class system for constructing gene editing disease models.

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