Normal allele: CC
TPH2 gene polymorphism increases the risk and magnitude of depressive disorder.
Polymorphism rs1386494 is related to topics like this:
Research and publications:
17123728 Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder.
18832011 Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers.
19184136 Examination of association of genes in the serotonin system to autism
19590397 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
19674121 Examination of tetrahydrobiopterin pathway genes in autism.
19679166 TPH2 polymorphisms may modify clinical picture in treatment-resistant depression.
21172166 Pharmacogenetics of antidepressant response.
21531467 Serotonin-related gene pathways associated with undifferentiated somatoform disorder.
21655053 The genetic basis of panic disorder.
21687501 Pharmacogenetics of antidepressants.
22693556 TPH2 gene polymorphisms and major depression--a meta-analysis.
24711381 Social disadvantage, genetic sensitivity, and children's telomere length.
25152196 Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population.
25324626 Research in China on the molecular genetics of schizophrenia.