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SNP information rs1386494

RS1386494

Normal allele: CC

TPH2 gene polymorphism increases the risk and magnitude of depressive disorder.

Polymorphism rs1386494 is related to topics like this:

Serotonin transporter sert

In humans, the SLC6A4 gene encodes a protein referred to as both the sodium-dependent serotonin...

Depression is it genetic

Depression, also referred to as major depression or major depressive disorder, is a psychiatric...


Research and publications:

  17123728   Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder.

  18832011   Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers.

  19184136   Examination of association of genes in the serotonin system to autism

  19359258   Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

  19590397   5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.

  19674121   Examination of tetrahydrobiopterin pathway genes in autism.

  19679166   TPH2 polymorphisms may modify clinical picture in treatment-resistant depression.

  19742166   Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

  21172166   Pharmacogenetics of antidepressant response.

  21531467   Serotonin-related gene pathways associated with undifferentiated somatoform disorder.

  21621273   Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.

  21655053   The genetic basis of panic disorder.

  21687501   Pharmacogenetics of antidepressants.

  22693556   TPH2 gene polymorphisms and major depression--a meta-analysis.

  23063133   Genetics of emergent suicidality during antidepressive treatment--data from a naturalistic study on a large sample of inpatients with a major depressive episode.

  24376086   Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population.

  24711381   Social disadvantage, genetic sensitivity, and children's telomere length.

  25005534   Association of TPH-1 and TPH-2 gene polymorphisms with suicidal behavior: a systematic review and meta-analysis.

  25152196   Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population.

  25324626   Research in China on the molecular genetics of schizophrenia.

  27521242   TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.

  27721799   Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions.

  27871272   Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population.

  29314569   Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.

  31291234   Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD.

  33968131   The 5-HTTLPR-rs25531 S-A-S-A Haplotype and Chronic Stress Moderate the Association Between Acute Stress and Internalizing Mental Disorders Among HIV+ Children and Adolescents in Uganda.

CYP21 deficiency

The inability to synthesize cortisol, known as congenital adrenal hyperplasia (CAH), is responsible...

Dopamine transporter genes

The membrane-bound protein called the dopamine transporter (DAT), also known as the...

Mitochondria dna

The mitochondria contain circular chromosomes known as mitochondrial DNA and are organelles...

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