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SNP information rs6295


Normal allele: GG

The 5-HT1A gene polymorphism increases the risk and magnitude of depressive disorder.

Polymorphism rs6295 is related to topics like this:

Serotonin transporter sert

In humans, the SLC6A4 gene encodes a protein referred to as both the sodium-dependent serotonin...

Research and publications:

  16626484   The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt.

  17192951   HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers.

  18047755   5-HT1A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies.

  18081710   Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.

  18163385   Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders.

  18308786   The --1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients.

  18387137   5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder.

  18387740   Serotonin receptor 1A-1019C/G variant: impact on antidepressant pharmacoresponse in melancholic depression?

  18484082   Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder.

  18639564   Transcriptional regulation at a HTR1A polymorphism associated with mental illness.

  18663369   Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR).

  18715570   Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls.

  18848359   The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population.

  19124686   Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety.

  19326813   [5-HT1A gene polymorphisms contributed to antidepressant response in major depression].

  19358877   Imaging phenotypes of major depressive disorder: genetic correlates.

  19359258   Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

  19403460   Pharmacogenetics of antidepressant response: an update.

  19428959   5-HT(1A) receptor function in major depressive disorder.

  19560507   Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder.

  19590397   5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.

  19725031   Significant association between the C(-1019)G functional polymorphism of the HTR1A gene and impulsivity.

  19730445   Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis.

  19747927   Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients.

  19800133   Early response to selective serotonin reuptake inhibitors in panic disorder is associated with a functional 5-HT1A receptor gene polymorphism.

  19829169   SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.

  19894072   A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder.

  19897250   An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population.

  19997044   No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressfu

  20008943   Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.

  20043001   Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders.

  20454985   Associations between the serotonin-1A receptor C(-1019)G polymorphism and disordered eating symptoms in female adolescents.

  20594600   Serotonin 1A receptor gene, schizophrenia and bipolar disorder: an association study and meta-analysis.

  20633049   Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?

  20638825   The HTR1A and HTR1B receptor genes influence stress-related information processing.

  21172166   Pharmacogenetics of antidepressant response.

  21208417   International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol.

  21225419   Gene-environment interactions: early life stress and risk for depressive and anxiety disorders.

  21449006   Role of COMT, 5-HT(1A) , and SERT genetic polymorphisms on antidepressant response to Transcranial Magnetic Stimulation.

  21621273   Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.

  21687501   Pharmacogenetics of antidepressants.

  21688171   Determinants of pharmacodynamic trajectory of the therapeutic response to paroxetine in Japanese patients with panic disorder.

  21711518   Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms.

  21728034   Methamphetamine-associated psychosis.

  21750702   Genomewide association scan of suicidal thoughts and behaviour in major depression.

  22064163   Sertraline (Zoloft) response in major depressive disorder is not associated with three 5-HT1A receptor gene polymorphisms (rs6295, rs10042486, or rs1364043) in Chinese-Han patients.

  22105624   The genetics of attention deficit/hyperactivity disorder in adults, a review.

  22170779   Association study of serotonin pathway genes in attempted suicide.

  22224195   Epigenetics in Developmental Disorder: ADHD and Endophenotypes.

  22232550   Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice.

  22392387   No association between the HTR1A gene and suicidal behavior: a meta-analysis.

  22563461   HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13.

  22727709   Evaluation of genetic models for response in a randomized clinical trial of duloxetine in major depressive disorder.

  22752684   The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder.

  22826341   Transcriptional regulation of the 5-HT1A receptor: implications for mental illness.

  22890315   Association between the 5-HT1A receptor gene polymorphism (rs6295) and antidepressants: a meta-analysis.

  22933845   Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse.

  22992668   Pharmacogenomics knowledge for personalized medicine.

  23036158   The combined effects of the 5- HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients.

  23192369   Relationship between genetic polymorphisms in the HTR1A gene and paranoid schizophrenia in a northern Han Chinese population.

  23318131   Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6 months after lumbar disc surgery.

  23333373   Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue.

  23375453   Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population.

  23499153   Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy.

  23537781   Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients.

  23547754   Genetics of serotonin receptors and depression: state of the art.

  23733030   Pharmacogenetics in major depression: a comprehensive meta-analysis.

  23911056   Association of 5HTR1A gene variants with suicidal behavior: case-control study and updated meta-analysis.

  23992222   The role of serotonin receptor alleles and environmental stressors in the development of post-concussive symptoms after pediatric mild traumatic brain injury.

  24021217   Common selective serotonin reuptake inhibitor side effects in older adults associated with genetic polymorphisms in the serotonin transporter and receptors: data from a randomized controlled trial.

  24086514   Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study.

  24158751   The effect of serotonin 1A receptor polymorphism on the cognitive function of premenstrual dysphoric disorder.

  24304270   Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants.

  24319431   Mechanisms of antidepressant resistance.

  24331356   Methylation at a transcription factor-binding site on the 5-HT1A receptor gene correlates with negative symptom treatment response in first episode schizophrenia.

  24460115   There is no association between the serotonin receptor gene and bipolar I disorder in the Korean population.

  24462335   Serotonin-1A receptor CC genotype is associated with persistent depression related to interferon-alpha in hepatitis C patients.

  24596569   Gene-environment interactions and intermediate phenotypes: early trauma and depression.

  24643765   5-HTTLPR, HTR1A, and HTR2A cumulative genetic score interacts with mood reactivity to predict mood-congruent gaze bias.

  24881125   From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment.

  24944790   Screening for 392 polymorphisms in 141 pharmacogenes.

  25247748   Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation.

  25264393   Association between serotonin cumulative genetic score and the Behavioral Approach System (BAS): Moderation by early life environment.

  25412229   The association between romantic relationship status and 5-HT1A gene in young adults.

  25514753   The functional -1019C/G HTR1A polymorphism and mechanisms of fear.

  25560469   COMT Val158Met and 5-HT1A-R -1019 C/G polymorphisms: effects on the negative symptom response to clozapine.

  25733959   Pharmacogenetics and outcome with antipsychotic drugs.

  25781924   Association of functional polymorphisms from brain-derived neurotrophic factor and serotonin-related genes with depressive symptoms after a medical stressor in older adults.

  25822479   HTR1A Gene Polymorphisms and 5-HT1A Receptor Partial Agonist Antipsychotics Efficacy in Schizophrenia.

  25990886   Impact of monoamine-related gene polymorphisms on hippocampal volume in treatment-resistant depression.

  26261165   Association of serotonin transporter (SLC6A4) and receptor (5HTR1A, 5HTR2A) polymorphisms with response to treatment with escitalopram in patients with major depressive disorder: A preliminary study.

  26352193   Alcohol Dependence and Genetic Variability in the Serotonin Pathway among Currently and Formerly Alcohol-Dependent Males.

  26543368   Epidemiological support for genetic variability at hypothalamic-pituitary-adrenal axis and serotonergic system as risk factors for major depression.

  26544898   The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment--a European multicentre study.

  26568455   HTR1A Polymorphisms and Clinical Efficacy of Antipsychotic Drug Treatment in Schizophrenia: A Meta-Analysis.

  26743651   Evidence for genetic regulation of mRNA expression of the dosage-sensitive gene retinoic acid induced-1 (RAI1) in human brain.

  26780922   Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder.

  26926882   The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription.

  27445478   5-HTR1A and 5-HTR2A genetic polymorphisms and SSRI antidepressant response in depressive Chinese patients.

  27445670   5-HT2A Gene Variants Moderate the Association between PTSD and Reduced Default Mode Network Connectivity.

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