SNP information rs4570625

Research and publications:

  16116490   Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.

  16146581   Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder.

  17176491   Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance.

  17176492   Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.

  17346350   Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1.

  17568567   Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons.

  17892388   Genetic variation of serotonin function and cognitive control.

  18427560   Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals.

  18782386   Tryptophan hydroxylase 2 gene and alcohol use among college students.

  19077664   Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.

  19132526   A tryptophan hydroxylase 2 gene polymorphism is associated with panic disorder.

  19361870   TPH2 gene variants and anxiety during alcohol detoxification outcome.

  19742166   Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

  19894072   A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder.

  20043001   Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders.

  20111992   Description and validation of a dynamical systems model of presynaptic serotonin function: genetic variation, brain activation and impulsivity.

  20126463   Alternative splicing and extensive RNA editing of human TPH2 transcripts.

  20159345   Molecular genetics of attention deficit hyperactivity disorder.

  20331984   Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes.

  20938755   Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.

  21073637   Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome.

  21143251   A candidate gene association study of alcohol consumption in young women.

  21172166   Pharmacogenetics of antidepressant response.

  21333900   The role of genetics in IBS

  21396719   Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia.

  21418063   Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants.

  21655053   The genetic basis of panic disorder.

  22105624   The genetics of attention deficit/hyperactivity disorder in adults, a review.

  22224195   Epigenetics in Developmental Disorder: ADHD and Endophenotypes.

  22322887   Emotion appraisal and the tryptophan hydroxylase 2 (TPH2) gene.

  22392150   Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.

  22655589   Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.

  22693556   TPH2 gene polymorphisms and major depression--a meta-analysis.

  22698518   Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients

  22835848   Tryptophan hydroxylase 2 gene polymorphisms and poststroke anxiety disorders.

  22868061   The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism.

  22957066   Functional gene polymorphisms in the serotonin system and traumatic life events modulate the neural basis of fear acquisition and extinction.

  23552096   Associations between prefrontal γ-aminobutyric acid concentration and the tryptophan hydroxylase isoform 2 gene, a panic disorder risk allele in women.

  23628433   Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.

  23970845   The Genetics of Obsessive-Compulsive Disorder.

  24304270   Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants.

  24491795   Tryptophan hydroxylase 2 (TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe epilepsy.

  24711381   Social disadvantage, genetic sensitivity, and children's telomere length.

  25005534   Association of TPH-1 and TPH-2 gene polymorphisms with suicidal behavior: a systematic review and meta-analysis.

  25455586   Effect of tryptophan hydroxylase-2 gene polymorphism G-703 T on personality in a population representative sample.

  25548468   Genetic polymorphism in pathogenesis of irritable bowel syndrome.

  26013962   Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users.

  26227246   Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry.

  26232682   Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms.

  26272535   The placebo effect: From concepts to genes.

  26386440   Interaction of tryptophan hydroxylase 2 gene and life events in susceptibility to major depression in a Chinese Han population.

  26745768   Genetic variation in the tryptophan hydroxylase 2 gene moderates depressive symptom trajectories and remission over 8 weeks of escitalopram treatment.

  26975194   Serotonin and rich brain club association between molecular genetic variation in the TPH2 gene and the structural connectome.

  26989097   Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.

  27199691   To Cheat or Not To Cheat: Tryptophan Hydroxylase 2 SNP Variants Contribute to Dishonest Behavior.

  27521242   TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.

  27695066   A Novel Interaction between Tryptophan Hydroxylase 2 (TPH2) Gene Polymorphism (rs4570625) and BDNF Val66Met Predicts a High-Risk Emotional Phenotype in Healthy Subjects.

  27807918   Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase-2 (TPH2) polymorphism.

  27824354   Serotonergic modulation of “anticipatory impulsivity” is mediated by the impulsivity phenotype in humans.

  27871272   Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population.

  27926628   Variants of TPH2 interact with fast visual processing as assessed by metacontrast.

  28193370   [Characterisation of three polymorphisms of the tryptophan hydroxylase 2 gene in a sample of Colombian population with major depressive disorder].

  28342337   Nice guys: Homozygocity for the TPH2 -703G/T (rs4570625) minor allele promotes low aggressiveness and low anxiety.

  28456685   Association of regulatory TPH2 polymorphisms with higher reduction in depressive symptoms in children and adolescents treated with fluoxetine.

  29310005   Association of serotonergic pathway genes with smoking cessation in a Chinese rural male population.

  29314569   Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.

  29358097   The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort.

  29775696   TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.

  30083112   Genetics Factors in Major Depression Disease.

  30098258   [Association of TPH2 gene polymorphism with response to antidepressant treatment among ethnic Han Chinese population].

  30309244   Association of Fatigue With TPH2 Genetic Polymorphisms in Women With Irritable Bowel Syndrome.

  30519155   TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom.

  30822678   Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naïve major depressive disorder patients.

  31552390   Placebo effects and the molecular biological components involved.

  31817010   Variation of Genes Encoding Tryptophan Catabolites Pathway Enzymes in Stroke.

  32338242   Reward sensitivity, affective neuroscience personality, symptoms of attention-deficit/hyperactivity disorder, and TPH2-703G/T (rs4570625) genotype.

  32576619   Effects of TPH2 gene variation and childhood trauma on the clinical and circuit-level phenotype of functional movement disorders.

  32711172   The role of TPH2 variant rs4570625 in shaping infant attention to social signals.

  32981537   Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior - a TPH2 imaging genetics approach.

  33450468   The relationship between occupational stress, musculoskeletal disorders and the mental health of coal miners: The interaction between BDNF gene, TPH2 gene polymorphism and the environment.

  33523602   REVERSE phenotyping-Can the phenotype following constitutive Tph2 gene inactivation in mice be transferred to children and adolescents with and without adhd?

  33968131   The 5-HTTLPR-rs25531 S-A-S-A Haplotype and Chronic Stress Moderate the Association Between Acute Stress and Internalizing Mental Disorders Among HIV+ Children and Adolescents in Uganda.

  33986383   Prediction of functional outcomes of schizophrenia with genetic biomarkers using a bagging ensemble machine learning method with feature selection.

  34515911   Monoaminergic Multilocus Genetic Variants Interact with Stressful Life Events in Predicting Changes in Adolescent Anxiety Symptoms: A One-year Longitudinal Study.

  34979191   Meta-analysis of association between TPH2 single nucleotide poiymorphism and depression.

  35207756   Serotonin-related functional genetic variants influence the occurrence of psychiatric and motor side effects of dopaminergic treatment in Parkinson's disease: a retrospective cohort study.