Normal allele: CC
2-fold risk of severe alcohol withdrawal. Associated with more severe symptoms after alcohol withdrawal, such as seizures and white fever. Possible increased chance of ADHD.
Polymorphism rs27072 is related to topics like this:
Research and publications:
18690117 Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers.
19494806 Dopamine genes and nicotine dependence in treatment-seeking and community smokers.
20732623 Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder.
20732626 Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.
20732627 Case-control genome-wide association study of attention-deficit/hyperactivity disorder.
21527290 Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood.
24780147 Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder.
24889756 Preliminary investigation of the influence of dopamine regulating genes on social working memory.
25324626 Research in China on the molecular genetics of schizophrenia.
25545355 Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents.
25819021 A review of pharmacogenetic studies of substance-related disorders.
30093869 Biological Predictors of Clozapine Response: A Systematic Review.
31440993 A Meta-analysis of the Association Between SLC6A3 Gene Polymorphisms and Schizophrenia.
35237725 Factors in the neurodevelopment of negative urgency: Findings from a community-dwelling sample.
35940320 Interaction between manganese and SLC6A3 genetic polymorphisms in relation to dyslexia.