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SNP information rs25532


Normal allele: AA

Each C rs25532 allele accounts for increased serotonin transporter function and is pathogenetically associated with OCD.

Polymorphism rs25532 is related to topics like this:

Is OCD obsessive compulsive disorder genetic

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by features known as...

Research and publications:

  18055562   A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder.

  18444253   Additional functional variation at the SLC6A4 gene.

  18824000   How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems.

  21364196   A polymorphism in the serotonin transporter gene moderates cardiovascular reactivity to psychosocial stress.

  21439906   Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease.

  21453464   The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits.

  23510579   Worldwide population variation and haplotype analysis at the serotonin transporter gene SLC6A4 and implications for association studies.

  25818147   The Impact of Genetics on Physical Resilience and Successful Aging.

  25957993   Interactive effects of citalopram and serotonin transporter genotype on neural correlates of response inhibition and attentional orienting.

  26189450   Genetic Moderation of Stress Effects on Corticolimbic Circuitry.

  26464328   Role of the 5-HTTLPR and SNP Promoter Polymorphisms on Serotonin Transporter Gene Expression: a Closer Look at Genetic Architecture and In Vitro Functional Studies of Common and Uncommon Allelic Variants.

  27375535   Molecular Signatures of Natural Selection for Polymorphic Genes of the Human Dopaminergic and Serotonergic Systems: A Review.

  27462201   From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research.

  27708560   Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology.

  27933583   Looking Beyond the 5-HTTLPR Polymorphism: Genetic and Epigenetic Layers of Regulation Affecting the Serotonin Transporter Gene Expression.

  28691545   Association of the functional serotonin transporter haplotype with familial form of obsessive compulsive disorder in Iranian patients.

  29102815   Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder.

  30083112   Genetics Factors in Major Depression Disease.

  31552390   Placebo effects and the molecular biological components involved.

  33198140   Phased Haplotype Resolution of the SLC6A4 Promoter Using Long-Read Single Molecule Real-Time (SMRT) Sequencing.

  33445578   Elevated Expression of SLC6A4 Encoding the Serotonin Transporter (SERT) in Gilles de la Tourette Syndrome.

  23630162   Common and rare alleles of the serotonin transporter gene SLC6A4 associated with Tourette syndrome.

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