Upload the DNA data file of the test

23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage

and get an enhanced
personalized health report
free without registration

Files accepted .txt, .csv, .zip, .csv.gz

File data is not stored on the server

SNP information rs25531


Normal allele: TT

The serotonin transporter rs25531 polymorphism is associated with neuroticism, depression, OCD, ADHD and autism spectrum disorder.

Polymorphism rs25531 is related to topics like this:

DNA test for autism

We recommend that anyone who has been diagnosed with autism undergo genetic testing. Unfortunately,...

Is OCD obsessive compulsive disorder genetic

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by features known as...

Research and publications:

  15993855   Sequence analysis of the serotonin transporter and associations with antidepressant response.

  16402131   Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531.

  17284168   Serotonergic genes modulate amygdala activity in major depression.

  17375136   A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder.

  18050262   Serotonin transporter polymorphism (5-HTTLPR) association with melancholic depression: a female specific effect?

  18441666   Extended evaluation of serotonin transporter gene functional polymorphisms in subjects with post-stroke depression.

  18444253   Additional functional variation at the SLC6A4 gene.

  18465388   The serotonin transporter polymorphisms and major depression following traumatic brain injury.

  18618621   SLC6A4 variation and citalopram response.

  18629430   Blushing propensity in social anxiety disorder: influence of serotonin transporter gene variation.

  18661222   5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion.

  18824000   How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems.

  18951433   Lack of association of the serotonin transporter gene promoter region polymorphism, 5-HTTLPR, including rs25531 with cigarette smoking and alcohol consumption.

  18981341   Association of serotonin transporter gene polymorphisms with poststroke depression.

  19015103   Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting.

  19020798   Association study to evaluate the serotonin transporter and apolipoprotein E genes in frontotemporal lobar degeneration in Italy.

  19103261   Novel allelic variants in the human serotonin transporter gene linked polymorphism (5-HTTLPR) among depressed patients with suicide attempt.

  19122845   An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood.

  19125330   The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome.

  19249159   Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion.

  19272758   Serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression.

  19429111   No association was found between serotonin transporter gene polymorphisms and depression in Parkinson's disease in Chinese people.

  19487392   Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population.

  19521089   The 5-HTTLPR polymorphic element of the serotonin transporter gene increases the risk of sporadic Parkinson's disease in Italy.

  19541292   Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality Measures.

  19570226   Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans.

  19588468   Association and gene-gene interaction of SLC6A4 and ITGB3 in autism.

  19625753   A polymorphic region of the serotonin transporter promoter is not a risk factor for behavioral disorders associated with Alzheimer's disease.

  19655247   Genetics and irritable bowel syndrome: from genomics to intermediate phenotype and pharmacogenetics.

  19685963   Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli.

  19742166   Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

  19806148   Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study.

  19860858   Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF.

  19884608   Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.

  19911410   Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sample.

  19944766   A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia

  19962442   Emotion specific modulation of automatic amygdala responses by 5-HTTLPR genotype.

  19969287   Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder.

  19996755   Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms.

  20029939   Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms.

  20031235   Serotonin transporter polymorphisms and early response to antipsychotic treatment in first episode of psychosis.

  20090673   Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression.

  20146650   Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder.

  20175892   Study of the serotonin transporter (SLC6A4) and BDNF genes in French patients with non syndromic mental deficiency.

  20373668   Psychiatric pharmacogenomic testing in clinical practice.

  20406689   Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain.

  20450949   Serotonin transporter gene polymorphisms and treatment-resistant depression.

  20452607   Influence of serotonin transporter gene polymorphisms on clozapine response in Brazilian schizophrenics.

  20452754   Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes.

  20455953   Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression.

  20462563   Analysis of the serotonin transporter promoter rs25531 polymorphism in premenstrual dysphoric disorder.

  20468059   No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition.

  20505557   Haplotypes of dopamine and serotonin transporter genes are associated with antisocial personality disorder in alcoholics.

  20515362   Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury.

  20549395   Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies

  20584552   The role of clinical variables, neuropsychological performance and SLC6A4 and COMT gene polymorphisms on the prediction of early response to fluoxetine in major depressive disorder.

  20588071   Norepinephrine and serotonin transporter genes: impact on treatment response in depression.

  20691427   Genetic associations of brain structural networks in schizophrenia: a preliminary study

  20838391   Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence.

  20862697   Rare genotype combination of the serotonin transporter gene associated with treatment response in severe personality disorder.

  20920548   Lack of association between the 5-HTTLPR and the error-related negativity (ERN).

  20971165   Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions.

  21105279   Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults.

  21166770   Dopamine D4 receptor and serotonin transporter gene effects on the longitudinal development of infant temperament.

  21172166   Pharmacogenetics of antidepressant response.

  21232011   Serotonin transporter allelic variation in mothers predicts maternal sensitivity, behavior and attitudes toward 6-month-old infants.

  21290142   Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour.

  21319930   Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information.

  21333900   The role of genetics in IBS

  21356267   5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation.

  21364196   A polymorphism in the serotonin transporter gene moderates cardiovascular reactivity to psychosocial stress.

  21364197   Effects of 5HTTLPR on cardiovascular response to an emotional stressor.

  21423614   Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene.

  21429092   Serotonin transporter gene variants and prediction of stress-induced risk for psychological distress.

  21439906   Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease.

  21441157   Serotonin transporter gene polymorphism in Chinese patients with poststroke depression: a case-control study.

  21453464   The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits.

  21497794   A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings.

  21504541   Association between neonatal temperament, SLC6A4, DRD4 and a functional polymorphism located in TFAP2B.

  21545724   Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder.

  21658141   Genetic variants in the serotonin transporter influence the efficacy of bupropion and nortriptyline in smoking cessation.

  21670732   Identification of tag haplotypes for 5HTTLPR for different genome-wide SNP platforms.

  21681867   Serotonin transporter gene and childhood trauma--a G × E effect on anxiety sensitivity.

  21687501   Pharmacogenetics of antidepressants.

  21692988   No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression.

  21808609   Components of cross-frequency modulation in health and disease.

  21818827   The relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR/rs25531 polymorphism.

  21893641   Acute and posttraumatic stress symptoms in a prospective gene x environment study of a university campus shooting.

  21917807   Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning.

  22058430   Genetic basis of pain variability: recent advances.

  22086748   The serotonin transporter promoter polymorphism (5-HTTLPR) affects the relation between antidepressant serum concentrations and effectiveness in major depression.

  22094432   Perception of a naturalistic stressor interacts with 5-HTTLPR/rs25531 genotype and gender to impact reward responsiveness.

  22105624   The genetics of attention deficit/hyperactivity disorder in adults, a review.

  22271047   Examining associations between disordered eating and serotonin transporter gene polymorphisms.

  22271509   Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women.

  22348680   Somatic markers mediate the effect of serotonin transporter gene polymorphisms on Iowa Gambling Task.

  22384070   AVPR1A and SLC6A4 polymorphisms in choral singers and non-musicians: a gene association study.

  22390669   The relationship between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in trajectories of anxiety/depressive symptoms in adolescents.

Gene for lactose intolerance

Lactose intolerance is a condition characterized by difficulty digesting lactose, a sugar present...

CCNB1 cyclin B1

Cyclin B1 serves as a regulatory protein pivotal in the process of mitosis. It forms complexes with...

DNA methylation genes

The Genetic Methylation Check examines your DNA to offer insights into your unique methylation...