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SNP information rs6277


Normal allele: GG

Associated with a 1.6-fold increased risk of schizophrenia.

Polymorphism rs6277 is related to topics like this:

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Research and publications:

  16848906   Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans

  16867246   Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients.

  17135598   No evidence for a major role of polymorphisms during bupropion treatment.

  18077373   Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.

  18255274   Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population.

  18332877   Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan.

  18563706   The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study.

  18690117   Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers.

  18698231   Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

  18821566   SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families.

  18929622   Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy.

  19065655   Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention Trial.

  19158809   Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population.

  19197363   A genome-wide investigation of SNPs and CNVs in schizophrenia.

  19258022   Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.

  19285111   C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo.

  19373123   Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution.

  19393722   Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms.

  19470168   NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.

  19512960   Genetic diagnostics of functional variants of the human dopamine D2 receptor gene.

  19590515   Association between dopaminergic genes (SLC6A3 and DRD2) and stuttering among Han Chinese.

  19693267   Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

  19911060   Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.

  19913597   An association study of DRD2 gene polymorphisms with schizophrenia in a Chinese Han population.

  19944766   A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia

  20046399   Genetic polymorphisms in dopamine- and serotonin-related genes and treatment responses to risperidone and perospirone.

  20133381   Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans.

  20179754   Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance.

  20180986   CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.

  20191112   The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.

  20205808   Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients.

  20421849   Habituation in prepulse inhibition is affected by a polymorphism on the NMDA receptor 2B subunit gene (GRIN2B).

  20549395   Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies

  20567893   Association between polymorphisms of the dopamine receptor D2 and catechol-o-methyl transferase genes and cognitive function.

  20615259   A polymorphism in the dysbindin gene (DTNBP1) associated with multiple psychiatric disorders including schizophrenia.

  20631687   Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility

  20691427   Genetic associations of brain structural networks in schizophrenia: a preliminary study

  20714340   Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain.

  20736885   PharmGKB summary: dopamine receptor D2.

  20954426   Genetics in schizophrenia: where are we and what next?

  21130611   Evidence for the modality independence of the genetic epistasis between the dopaminergic and cholinergic system on working memory capacity.

  21150907   Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.

  21172166   Pharmacogenetics of antidepressant response.

  21289622   Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.

  21483435   Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.

  21508242   Dopaminergic genes predict individual differences in susceptibility to confirmation bias.

  21519536   No Evidence for an Association between Dopamine D2 Receptor Polymorphisms and Tardive Dyskinesia in Korean Schizophrenia Patients.

  21527290   Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood.

  21781348   Genetic polymorphisms involved in dopaminergic neurotransmission and risk of Parkinson's disease in a Japanese population.

  21808609   Components of cross-frequency modulation in health and disease.

  21843369   Possible association between interleukin-1β gene and schizophrenia in a Japanese population.

  21853134   Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.

  21861710   A novel DRD2 single-nucleotide polymorphism associated with schizophrenia predicts age of onset: HapMap tag-single-nucleotide polymorphism analysis.

  21948099   Can the chronic administration of the combination of buprenorphine and naloxone block dopaminergic activity causing anti-reward and relapse potential?

  21981786   The genetic validation of heterogeneity in schizophrenia.

  22022190   No association of functional polymorphisms in methlylenetetrahydrofolate reductase and the risk and minor physical anomalies of schizophrenia in Korean population.

  22382052   A DRD2 and ANKK1 haplotype is associated with nicotine dependence.

  22487365   C957T polymorphism of the dopamine D2 receptor gene is associated with motor learning and heart rate.

  22574669   Dopamine receptors D1 and D2 are related to observed maternal behavior.

  22579533   Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes.

  22582185   DRD2 C957T and TaqIA genotyping reveals gender effects and unique low-risk and high-risk genotypes in alcohol dependence.

  22640745   The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD.

  22650965   Paradox of schizophrenia genetics: is a paradigm shift occurring?

  22745721   Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study.

  22832657   A review on experimental and clinical genetic associations studies on fear conditioning, extinction and cognitive-behavioral treatment.

  22939506   Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory.

  22947540   The dopamine D2 receptor gene DRD2 and the nicotinic acetylcholine receptor gene CHRNA4 interact on striatal gray matter volume: evidence from a genetic imaging study.

  22963930   Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent.

  23376770   The genetic impact (C957T-DRD2) on inhibitory control is magnified by aging.

  23856854   Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders.

  24018103   Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia.

  24086514   Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study.

  24332987   Dopamine and glutamate receptor genes interactively influence episodic memory in old age.

  24379187   Single-nucleotide polymorphisms of the dopamine D2 receptor increase inflammation and fibrosis in human renal proximal tubule cells.

  24407958   Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures.

  24724616   Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

  24755993   Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences?

  24782743   Association of COMT and COMT-DRD2 interaction with creative potential.

  24819610   DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory.

  24944790   Screening for 392 polymorphisms in 141 pharmacogenes.

  25266489   Genetic polymorphisms of VIP variants in the Tajik ethnic group of northwest China.

  25510197   Dopamine and cognitive control: sex-by-genotype interactions influence the capacity to switch attention.

  25647695   Modulation of nicotine effects on selective attention by DRD2 and CHRNA4 gene polymorphisms.

  25658328   Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25819021   A review of pharmacogenetic studies of substance-related disorders.

  25955176   Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility.

  26044620   Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.

  26079805   Nicotinergic Modulation of Attention-Related Neural Activity Differentiates Polymorphisms of DRD2 and CHRNA4 Receptor Genes.

  26081799   Genetic and Functional Analysis of Polymorphisms in the Human Dopamine Receptor and Transporter Genes in Small Cell Lung Cancer.

  26091847   Genetic polymorphisms of pharmacogenomic VIP variants in the Uygur population from northwestern China.

  26114663   Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample.

  26220612   Genetic influences on delay discounting in smokers: examination of a priori candidates and exploration of dopamine-related haplotypes.

  26307064   DRD2 and DRD4 genes related to cognitive deficits in HIV-infected adults who abuse alcohol.

  26370377   Recurrent miscarriage is associated with the dopamine receptor (DRD2) genotype.

  26429319   Influence of dopamine receptor gene polymorphisms on circulating T lymphocytes: A pilot study in healthy subjects.

  26445370   Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status – The HUNT Study.

  26880915   Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents.

  26926883   Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.

  26954487   Individual differences in flow proneness are linked to a dopamine D2 receptor gene variant.

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