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Schizophrenia is it genetic

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A psychosis known as schizophrenia impacts an individual's thinking, sense of self, and perceptions, and is classified as a brain disorder. This disorder usually manifests during the late teenage years or early adulthood.

According to experts, there could be a correlation between schizophrenia and your genetic makeup - a molecular blueprint passed down from your parents that exists in every cell of your being. This blueprint plays a role in determining various aspects of your physical appearance, such as eye color and height, as well as certain facets of your character.

Scientists have identified at least 10 different possible genes that, when altered, can increase the risk of schizophrenia by a factor of four to 50, depending on the specific gene.

Despite the vast array of genetic variants associated with schizophrenia, research indicates that they are primarily concentrated in genes expressed in neurons. These findings suggest that both rare high-risk mutations and common low-risk genetic variants consistently implicate genes such as GRIN2A, which are also significant in epilepsy and neurodevelopmental disorders.

Alternatively, in some instances, the reason could be attributed to the removal of a particular group of genes. To illustrate, the elimination of 21 distinct genes through the "3q29 deletion" results in a 40-fold increase in susceptibility.

The likelihood of developing schizophrenia is believed to be influenced by variations in numerous genes. Typically, the risk of developing the disorder is increased by the combination of multiple genetic alterations, each with a minor impact. The relationship between these genetic changes and schizophrenia is not yet fully comprehended, and research into the genetics of this condition is ongoing. Additionally, these genetic changes can interact with environmental factors that are linked to an elevated risk of schizophrenia, such as prenatal exposure to infections or severe childhood stress.

The risk of schizophrenia may be heightened by the removal or duplication of genetic material in various chromosomes, potentially impacting multiple genes. One specific example is a microdeletion in the 22q11 region of chromosome 22, which may be linked to a minority of schizophrenia cases. Those with this deletion may also exhibit other symptoms, including heart defects, immune system issues, and a cleft palate, and may be diagnosed with 22q11.2 deletion syndrome.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Schizophrenia and see a list of existing studies.

SNP polymorphisms related to the topic Schizophrenia:

rs4129148There is a 3.23 times increased risk of developing schizophrenia.
rs12966547The rs12966547 variant of the long non-coding RNA LOC105372125 is significantly associated with susceptibility to schizophrenia and bipolar disorder.
rs1625579The risk genotype MIR137HG rs1625579 is associated with corpus callosum volume in schizophrenia
rs1800532The haplotype of the tryptophan hydroxylase gene (TPH1) is associated with an increased risk of schizophrenia and suicidal tendencies.
rs6675281The DISC1 locus modulates neurodevelopmental gene expression and is associated with cortical grey matter volumes and schizophrenia risk.
rs2312147Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in susceptibility to schizophrenia.
rs6603272Interleukin-3 receptor polymorphism is associated with schizophrenia, risk ratio 2.74.
rs947267Genetic variation in the DAOA gene is associated with schizophrenia and bipolar disorder.
rs165599Genetic variability in COMT increases the risk of psychotic and affective disorders.
rs6277Associated with a 1.6-fold increased risk of schizophrenia.
rs839523A SNP variant in ErbB4 is associated with bipolar affective disorder, major depressive disorder and schizophrenia.
rs1006737A polymorphism of the potential-dependent calcium channel gene CACNA1C, is associated with risk of bipolar disorder, schizophrenia and other psychiatric disorders.
rs2159100A polymorphism of the potential-dependent calcium channel gene CACNA1C, is associated with risk of bipolar disorder, schizophrenia and other psychiatric disorders.
rs1801028A polymorphism in the DRD2 gene for the dopamine D2 receptor increases 1.4-fold the risk of schizophrenia in the heterozygous GC genotype.
rs2270641A break in the vesicular monoamine transporter gene SLC18A1 - 3.7 times higher risk of schizophrenia.
rs4950928
rs4129585
rs11225703
rs778371
rs7085104
rs3738401
rs171748
rs7940866
rs12991836
rs4938445
rs9268895
rs855050
rs13194053
rs9272219
rs302719
rs16897515
rs10275045
rs1783925
rs36563
rs1411771
rs2812385
rs6541290
rs3738402
rs16854957
rs821722
rs2793093
rs9431714
rs2356606
rs967244
rs1073179
rs9663054
rs1417866
rs7221595
rs114002140
rs1198588
rs10789369
rs17504622
rs14403
rs11532322
rs10790212
rs175174
rs310762
rs795009
rs751229
rs497768
rs7598440
rs707284
rs27388
rs17101921
rs2024513
rs28694718
rs6422441
rs17883192
rs2848745
rs17651507
rs2437896
rs2499846
rs4958803
rs2053149
rs7582658
rs2119783
rs3131296
rs9960767
rs1502844
rs1572299
rs17512836
rs10503253
rs7004633
rs11191580
rs17662626
rs6932590
rs2910032
rs11995572
rs833497
rs4687552
rs2949006
rs1538774
rs2905424
rs6878284
rs2373000
rs6461049
rs4801131
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