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SNP information rs1801028

RS1801028

Normal allele: GG

A polymorphism in the DRD2 gene for the dopamine D2 receptor increases 1.4-fold the risk of schizophrenia in the heterozygous GC genotype.

Polymorphism rs1801028 is related to topics like this:

Schizophrenia is it genetic

A psychosis known as schizophrenia impacts an individual's thinking, sense of self, and...


Research and publications:

  18154681   A lesson not learned: allele misassignment.

  18332877   Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan.

  18715757   Genetic associations with schizophrenia: meta-analyses of 12 candidate genes

  18829695   Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia.

  19512960   Genetic diagnostics of functional variants of the human dopamine D2 receptor gene.

  19911060   Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.

  19913597   An association study of DRD2 gene polymorphisms with schizophrenia in a Chinese Han population.

  20046399   Genetic polymorphisms in dopamine- and serotonin-related genes and treatment responses to risperidone and perospirone.

  20179754   Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance.

  20421849   Habituation in prepulse inhibition is affected by a polymorphism on the NMDA receptor 2B subunit gene (GRIN2B).

  20549395   Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies

  20592018   D1 and D2 dopamine receptor-mediated inhibition of activated normal T cell proliferation is lost in jurkat T leukemic cells.

  20736885   PharmGKB summary: dopamine receptor D2.

  21162693   Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.

  21172166   Pharmacogenetics of antidepressant response.

  21519536   No Evidence for an Association between Dopamine D2 Receptor Polymorphisms and Tardive Dyskinesia in Korean Schizophrenia Patients.

  21687501   Pharmacogenetics of antidepressants.

  21714067   Association between polymorphisms of DRD2 and DRD4 and opioid dependence: evidence from the current studies.

  21728034   Methamphetamine-associated psychosis.

  21781348   Genetic polymorphisms involved in dopaminergic neurotransmission and risk of Parkinson's disease in a Japanese population.

  21981786   The genetic validation of heterogeneity in schizophrenia.

  22650965   Paradox of schizophrenia genetics: is a paradigm shift occurring?

  22963930   Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent.

  24881125   From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment.

  25504812   Association between DRD2 (rs1799732 and rs1801028) and ANKK1 (rs1800497) polymorphisms and schizophrenia: a meta-analysis.

  25711927   DRD2 Ser311Cys polymorphism and risk of schizophrenia.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  26730182   Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis.

  26824244   DNA Repair Gene (XRCC1) Polymorphism (Arg399Gln) Associated with Schizophrenia in South Indian Population: A Genotypic and Molecular Dynamics Study.

  26926883   Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.

  27217270   Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis.

  27375535   Molecular Signatures of Natural Selection for Polymorphic Genes of the Human Dopaminergic and Serotonergic Systems: A Review.

  27757066   Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations.

  27829443   The role of C957T, TaqI and Ser311Cys polymorphisms of the DRD2 gene in schizophrenia: systematic review and meta-analysis.

  28692863   Identification of genetic correlates of response to Risperidone: Findings of a multicentric schizophrenia study from India.

  29255361   Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia.

  29760667   A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese.

  30093869   Biological Predictors of Clozapine Response: A Systematic Review.

  30103286   Association between dopamine receptor gene polymorphisms and effects of risperidone treatment: A systematic review and meta-analysis.

  30389402   An association study of dopaminergic (DRD2) and serotoninergic (5-HT2) gene polymorphism and schizophrenia in a North Indian population.

  30607769   Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population.

  30967134   A pharmacogenetic study of patients with schizophrenia from West Siberia gets insight into dopaminergic mechanisms of antipsychotic-induced hyperprolactinemia.

  31744450   Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine.

  31848444   An epistasis between dopaminergic and oxytocinergic systems confers risk of post-traumatic stress disorder in a traumatized Chinese cohort.

  31995602   CalPen (Calculator of Penetrance), a web-based tool to estimate penetrance in complex genetic disorders.

  32420660   Synonymous polymorphism rs201256011 in dopamine receptor type 2 gene is associated with schizophrenia and PANSS score in Pakistani population: A first report.

  33588721   Risk Genes in Schizophrenia and Their Importance in Choosing the Appropriate Antipsychotic Treatment.

  34385834   Individualized drug selection by assessing drug properties, pharmacogenomics, and clinical parameters: effectiveness of a bioinformatics tool compared to a clinically established counseling process.

  34824904   Genetic diversity of "highly important pharmacogenes" in two South Asian populations.

  35140610   Genetic Factors Associated With Tardive Dyskinesia: From Pre-clinical Models to Clinical Studies.

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