SNP information rs165599

Research and publications:

  12802784   A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain

  15098000   COMT haplotypes suggest P2 promoter region relevance for schizophrenia

  15124004   Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families

  15457404   Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain

  15505638   Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia

  15570503   [No evidence for gender-specific sharing of COMT alleles in schizophrenia].

  15635644   A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).

  15931594   An entropy-based statistic for genomewide association studies

  15956988   COMT polymorphisms and anxiety-related personality traits

  15962707   The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia.

  16027741   Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease

  16232322   COMT genetic variation confers risk for psychotic and affective disorders: a case control study

  16380905   Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios

  16483362   The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression

  16525418   Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder.

  16786032   Impact of complex genetic variation in COMT on human brain function

  16816420   Nonlinear tests for genomewide association studies

  16876132   Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence.

  17006672   Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia

  17363961   Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment

  17427186   Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study

  17466074   Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study

  17482701   No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population

  17547583   COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance.

  17630406   Dopamine genes and schizophrenia: case closed or evidence pending?

  17707347   Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls

  17949513   Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS

  17961261   Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia

  18021915   Genetics and smoking cessation improving outcomes in smokers at risk.

  18081002   Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials

  18384078   Association study of candidate variants of COMT with neuroticism, anxiety and depression

  18436194   Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes

  18466879   Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample

  18574484   The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase

  18663369   Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR).

  18704099   Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.

  18715757   Genetic associations with schizophrenia: meta-analyses of 12 candidate genes

  19071221   Impact of interacting functional variants in COMT on regional gray matter volume in human brain.

  19077118   Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia.

  19095219   Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.

  19329282   Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.

  19365560   Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.

  19451915   Candidate-gene association analysis of response to risperidone in African-American and white patients with schizophrenia.

  19605537   Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children.

  19721400   Association between COMT gene and Chinese male schizophrenic patients with violent behavior.

  19997043   Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents.

  20080926   The influence of 5-HTT and COMT genotypes on verbal fluency in ecstasy users.

  20083391   A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry.

  20157235   Genetics of psychosis in Alzheimer's disease: a review.

  20531207   The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.

  20586531   The catechol-O-methyl-transferase gene in tardive dyskinesia.

  20627703   The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.

  20667552   Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.

  20877297   Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response.

  21172166   Pharmacogenetics of antidepressant response.

  21217836   No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population.

  21225419   Gene-environment interactions: early life stress and risk for depressive and anxiety disorders.

  21319490   Imaging genetics of schizophrenia.

  21462137   [An association study of COMT gene polymorphisms with schizophrenia].

  21595525   Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder.

  21609749   Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability.

  21656904   Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.

  21788083   Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.

  21934638   A COMT gene haplotype associated with methamphetamine abuse.

  21940152   The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder--a European multicenter study.

  22103610   Biomarkers to optimize the treatment of nicotine dependence.

  22348792   A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia.

  22713126   COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder.

  23178897   The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.

  23213652   Abstracts of the American College of Neuropsychopharmacology (ACNP) 51st Annual Meeting. December 2-6, 2012. Hollywood, Florida, USA.

  23332465   Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets.

  23598060   Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia.

  23762769   Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599.

  23963787   Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.

  23992923   Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.

  24944790   Screening for 392 polymorphisms in 141 pharmacogenes.

  24955500   Perceived stress during pregnancy and the catechol-O-methyltransferase (COMT) rs165599 polymorphism impacts on childhood IQ.

  25045629   Is catechol-o-methyltransferase gene polymorphism a risk factor in the development of premenstrual syndrome?

  25159270   Interactions between catechol-O-methyltransferase genotype, parenting, and gender predict childhood internalizing symptoms and inhibitory control: Evidence for differential susceptibility.

  25320962   COMT haplotypes modulate associations of antenatal maternal anxiety and neonatal cortical morphology.

  25744938   A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder.

  25819021   A review of pharmacogenetic studies of substance-related disorders.

  26073434   A novel association between COMT and BDNF gene polymorphisms and likelihood of symptomatic dysphagia in older people.

  26849490   Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.

  26858644   Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling.

  26920810   Modulative effects of COMT haplotype on age-related associations with brain morphology.

  27039372   Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder.

  27166759   Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.

  27521242   TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.

  27743374   Associations between genetic risk, functional brain network organization and neuroticism.

  27895608   Genetic Consideration of Schizotypal Traits: A Review.

  28041918   Prediction of functional outcome in young patients with a recent-onset psychiatric disorder: Beyond the traditional diagnostic classification system.

  28085950   Impact of DRD2/ANKK1 and COMT Polymorphisms on Attention and Cognitive Functions in Schizophrenia.

  28273278   Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls.

  28472995   Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men.

  28746172   A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers.

  28822116   Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.

  29255361   Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia.

  29559808   Association of genetic variation in COMT gene with pain related to sickle cell disease in patients from the walk-PHaSST study.