Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Alzheimer's disease and see a list of existing studies.
SNP polymorphisms related to the topic Alzheimer's disease:
|High levels of cerebrospinal tau are associated with the rs242557 gene variant and a high risk of Parkinson's and Alzheimer's disease.
|The APOE-E4 allele has a strong influence on the risk of developing Alzheimer's disease. One meta-analysis estimated the odds ratio for individuals homozygous for rs429358 to be 12 times higher for late-onset Alzheimer's disease and 61 times higher for early-onset disease. People with APOE4-4 allele C genotype should avoid eating animals raised on plants/grains that have higher levels of omega-6 compared to omega-3. It is advisable to practice vegetarianism to avoid all animal fats and measure the ratio of omega-3 to omega-6 in these people. Also, people with APOE 4 may do better on unmethylated forms of B12.
|The rs744373 polymorphism of the BIN1 1.28-fold increase in Alzheimer's disease risk is associated with more rapid AV-associated tau accumulation and cognitive decline.
|The ZCWPW1 polymorphism is associated with late-onset Alzheimer's disease.
|Polymorphism rs1799724 of the tumour necrosis factor alpha gene in Alzheimer's disease.
|The rs2075650 polymorphism of the TOMM40 gene contributes to the development of Alzheimer's disease and frontal temporal dementia in Caucasian and Asian populations.
|The CLU rs2279590 polymorphism contributes to susceptibility to Alzheimer's disease in Caucasian and Asian populations.
|Variation in the SORL1 gene is associated with hippocampal and brain atrophy and Alzheimer's disease.
|The rs2373115 polymorphism of the GAB2-associated binding protein gene indicates an increased risk (4.1-fold) of late-onset Alzheimer's disease.
|The NME8 rs2718058 polymorphism increases the risk of developing Alzheimer's disease.
|Analysis of large-scale samples confirms an association between the ABCA7 rs3764650 polymorphism and susceptibility to Alzheimer's disease.
|Association of the CD33 rs3865444 polymorphism with Alzheimer's disease pathology and CD33 expression in human cerebral cortex.
|A high-density, full-genome association study showed that APOE is a major susceptibility gene for sporadic late-onset Alzheimer's disease.
|An updated analysis of 85,939 samples confirms an association between the CR1 rs6656401 polymorphism and Alzheimer's disease.
|The rs7561528 polymorphism of the bridge integrator 1 gene contributes to susceptibility to Alzheimer's disease.
|Analysis of 54,936 samples confirms an association between the CD2AP rs9349407 polymorphism and susceptibility to Alzheimer's disease.
|Genetic variability at the CELF1 locus is genome-wide and is associated with Alzheimer's disease and obesity.
|Genetic alteration of the folate pathway affecting genomic methylation content.
|Genetic variation in EPHA1 affects cerebrospinal fluid and neuroimaging biomarkers in people with Alzheimer's disease.
|The rs17125944 FERMT2 polymorphism is associated with risk of developing Alzheimer's disease.
|The common PTK2B variant is associated with late-onset Alzheimer's disease.
|A polymorphism in the TREM2 gene on chromosome 6 resulting in an R47H substitution confers a significantly higher risk of late-onset Alzheimer's disease.