Normal allele: TT
The APOE-E4 allele has a strong influence on the risk of developing Alzheimer's disease. One meta-analysis estimated the odds ratio for individuals homozygous for rs429358 to be 12 times higher for late-onset Alzheimer's disease and 61 times higher for early-onset disease. People with APOE4-4 allele C genotype should avoid eating animals raised on plants/grains that have higher levels of omega-6 compared to omega-3. It is advisable to practice vegetarianism to avoid all animal fats and measure the ratio of omega-3 to omega-6 in these people. Also, people with APOE 4 may do better on unmethylated forms of B12.
Polymorphism rs429358 is related to topics like this:
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Research and publications :
The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia
Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity
Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant
Nucleotide sequence and structure of the human apolipoprotein E gene
Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms
Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene
Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3
Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms
Apolipoprotein E type 4 allele gene dosage and risk of Alzheimer's disease in late-onset families.
Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia
Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study
Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City
Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury
Association of apolipoprotein E polymorphism with outcome after head injury
Accelerated hippocampal atrophy in Alzheimer's disease with the apolipoprotein E epsilon4 allele
Apolipoprotein E epsilon 4 and short-term recovery from predominantly mild brain injury
APOE genotype influences acquisition and recall following traumatic brain injury
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo
Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4
Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis
Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes
ApoE genotype accounts for the vast majority of AD risk and AD pathology
Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele
APOE-epsilon4 predicts dementia but not other psychiatric disorders after traumatic brain injury
Impact of APOE in mild cognitive impairment
APOE genotype and cognitive decline in a middle-aged cohort
Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations
APOE and STH loci variations and Alzheimer's disease
Association of warfarin dose with genes involved in its action and metabolism
Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality
Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol
Comprehensive analysis of APOE and selected direct markers of late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association.
Evaluation of genetic factors for warfarin dose prediction
Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
Lack of replication of genetic associations with human longevity
Correction of population stratification in large multi-ethnic association studies
Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families
Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat
Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study
APOE/C1/C4/C2 hepatic control region polymorphism influences plasma apoE and LDL cholesterol levels
Evidence that the gene encoding insulin degrading enzyme influences human lifespan
New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background
The largest prospective warfarin-treated cohort supports genetic forecasting
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans
Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response
Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes
Genome-wide association study of late-onset Alzheimer's disease using pooled DNA.
About Jim Watson's APOE status: Genetic information is hard to hide.
Gender differences in genetic risk profiles for cardiovascular disease
Genome-wide association analysis identifies putative Alzheimer's disease susceptibility loci in addition to APOE
Analysis of the National Institute on Aging Family Study of Late-Onset Alzheimer's Disease: Impact of Additional Loci.
Application of two machine learning algorithms to genetic association studies in the presence of covariates
A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease
A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients
The complex interaction between APOE promoter and AD: an Italian case-control study
The GAB2 gene does not alter the risk of Alzheimer's disease in Spanish APOE 4 carriers.
Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach
Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response
Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample
Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk
Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals
A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study
Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients
APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure
Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study
Sequence variation in SORL1 and dementia risk in Swedes
Identification of genetic variants associated with response to statin therapy
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel Alzheimer's disease susceptibility genes.
Genome-wide association study identifies CLU and PICALM variants associated with Alzheimer's disease.
A simple and efficient algorithm for genome-wide homozygosity analysis in disease
FAS gene, brain volume and disease progression in Alzheimer's disease.
Introduction to the DISRUPT postprandial database: subjects, studies and methodologies
Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm
Air pollution, obesity, genes and cellular adhesion molecules
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis
Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease
Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women
Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk
Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer
Progression of geographic atrophy and genotype in age-related macular degeneration
Genotyping sleep disorders patients
Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey
Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study
Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Key goals, progress, and genetics roadmap.
Genome-wide analysis of genetic loci associated with Alzheimer disease
Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls
APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men
Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies
CLIA-tested genetic variants on commercial SNP arrays: potential for incidental findings in genome-wide association studies
Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project
HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging
A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India
A pilot study of gene/gene and gene/environment interactions in Alzheimer disease
Isoform of APOE with retained intron 3; quantitation and identification of an associated single nucleotide polymorphism
Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study
