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SNP information rs429358

Normal allele: TT

The APOE-E4 allele has a strong influence on the risk of developing Alzheimer's disease. One meta-analysis estimated the odds ratio for individuals homozygous for rs429358 to be 12 times higher for late-onset Alzheimer's disease and 61 times higher for early-onset disease. People with APOE4-4 allele C genotype should avoid eating animals raised on plants/grains that have higher levels of omega-6 compared to omega-3. It is advisable to practice vegetarianism to avoid all animal fats and measure the ratio of omega-3 to omega-6 in these people. Also, people with APOE 4 may do better on unmethylated forms of B12.

Polymorphism rs429358 is related to topics like this:

Alzheimer's disease
Stomach cancer
Vegetarian diet


Research and publications:

  1730728   The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia

  2341812   Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity

  2539388   Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant

  2987927   Nucleotide sequence and structure of the human apolipoprotein E gene

  3585172   Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms

  3922972   Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene

  6860421   Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3

  7263700   Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms

  8346443   Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

  8488843   Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia

  8618665   Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study

  8644717   Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City

  9932938   Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury

  10213549   Association of apolipoprotein E polymorphism with outcome after head injury

  11835377   Accelerated hippocampal atrophy in Alzheimer's disease with apolipoprotein E epsilon4 allele

  11940689   Apolipoprotein E epsilon 4 and short-term recovery from predominantly mild brain injury

  11940706   APOE genotype influences acquisition and recall following traumatic brain injury

  14741101   ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo

  15048896   Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4

  15113403   Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis

  15157284   Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes

  15172743   ApoE genotype accounts for the vast majority of AD risk and AD pathology

  15184602   Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele

  15326261   APOE-epsilon4 predicts dementia but not other psychiatric disorders after traumatic brain injury

  15557508   Impact of APOE in mild cognitive impairment

  15668424   APOE genotype and cognitive decline in a middle-aged cohort

  16595073   Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations

  16603077   Variation at APOE and STH loci and Alzheimer's disease

  17048007   Association of warfarin dose with genes involved in its action and metabolism

  17356695   Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality

  17357073   Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol

  17434289   Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association

  17456829   Evaluation of genetic factors for warfarin dose prediction

  17672902   Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes

  17903299   A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

  18034366   Lack of replication of genetic associations with human longevity

  18196181   Correction of population stratification in large multi-ethnic association studies

  18216863   Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families

  18254975   Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat

  18275964   Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study

  18378515   APOE/C1/C4/C2 hepatic control region polymorphism influences plasma apoE and LDL cholesterol levels

  18448515   Evidence that the gene encoding insulin degrading enzyme influences human lifespan

  18513389   New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  18574025   The largest prospective warfarin-treated cohort supports genetic forecasting

  18583979   Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

  18596683   Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans

  18603647   Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response

  18678618   Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes

  18823527   A genome-wide association study for late-onset Alzheimer's disease using DNA pooling

  18941475   On Jim Watson's APOE status: genetic information is hard to hide

  18974842   Gender differences in genetic risk profiles for cardiovascular disease

  18976728   Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE

  19001172   Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci

  19014573   Application of two machine learning algorithms to genetic association studies in the presence of covariates

  19058936   A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females

  19118814   Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19172988   The complex interaction between APOE promoter and AD: an Italian case-control study

  19262956   GAB2 gene does not modify the risk of Alzheimer's disease in Spanish APOE 4 carriers

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19285141   Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response

  19299407   Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample

  19336475   Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk

  19377787   Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals

  19501493   A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study

  19541455   Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients

  19554612   APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure

  19602472   Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study

  19653016   Sequence variation in SORL1 and dementia risk in Swedes

  19667110   Identification of genetic variants associated with response to statin therapy

  19668339   Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease

  19734902   Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

  19756043   A simple and efficient algorithm for genome-wide homozygosity analysis in disease

  19766542   The FAS gene, brain volume, and disease progression in Alzheimer's disease

  19787382   Introduction to the DISRUPT postprandial database: subjects, studies and methodologies

  19818961   Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm

  19884647   Air pollution, obesity, genes and cellular adhesion molecules

  19913121   Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip

  19936222   Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis

  19951432   Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease

  20082485   Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women

  20100581   Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

  20167577   Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk

  20308031   Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer

  20381870   Progression of geographic atrophy and genotype in age-related macular degeneration

  20396431   Genotyping sleep disorders patients

  20406466   Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

  20429872   Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study

  20451875   Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans

  20460622   Genome-wide analysis of genetic loci associated with Alzheimer disease

  20467002   Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls

  20498921   APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men

  20549395   Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies

  20556870   CLIA-tested genetic variants on commercial SNP arrays: potential for incidental findings in genome-wide association studies

  20565774   Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project

  20569235   HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging

  20663622   A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India

  20682755   A pilot study of gene/gene and gene/environment interactions in Alzheimer disease

  20822524   Isoform of APOE with retained intron 3; quantitation and identification of an associated single nucleotide polymorphism

  20832063   Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study

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