SNP information rs2075650

Research and publications:

  17434289   Comprehensive analysis of APOE and selected direct markers of late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association.

  18262040   LDL-cholesterol concentrations: a genome-wide association study.

  18439548   Loci associated with metabolic syndrome pathways, including LEPR, HNF1A, IL6R, and GCKR, are associated with plasma C-reactive protein: the Women's Genome Health Study.

  18439552   Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.

  19060910   Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

  19060911   Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

  19118814   Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease

  19197348   Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae

  19299407   Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample

  19668339   Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel Alzheimer's disease susceptibility genes.

  19734902   Genome-wide association study identifies CLU and PICALM variants associated with Alzheimer's disease.

  19919681   Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

  19951432   Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease

  20061627   Genome-wide scanning of copy number alterations in late-onset Alzheimer's disease.

  20100581   Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

  20236449   Genetics of Alzheimer disease in the pre- and post-GWAS era.

  20451875   Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Key goals, progress, and genetics roadmap.

  20460622   Genome-wide analysis of genetic loci associated with Alzheimer disease

  20529013   APOE is not associated with Alzheimer disease: a cautionary tale of genotype imputation.

  20885792   Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.

  20932310   Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study.

  21098978   Identification of new candidate genes for Alzheimer's disease by autozygosity mapping using genome-wide SNP data.

  21123754   Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.

  21124753   Alzheimer's disease: diagnosis, prognosis and path to prevention.

  21303902   Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol.

  21379329   Genome-wide association of late-onset familial Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.

  21418511   Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.

  21459483   Using cerebrospinal fluid biomarkers to replicate genetic associations in Alzheimer's disease.

  21498624   Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people.

  21547229   Neuroimaging indicators as endophenotypes in Alzheimer's disease.

  21647738   Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

  21685912   Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.

  21738485   Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.

  21784354   The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype.

  21860704   Implications of discoveries from genome-wide association studies in current cardiovascular practice.

  21875899   Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour.

  21931794   Common variants in CRP and LEPR influence high sensitivity C-reactive protein levels in North Indians.

  21933389   "Alzheimer's disease signature": potential prospects for new biomarkers.

  21943158   Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.

  21966275   Large-scale gene-centric analysis identifies novel variants for coronary artery disease.

  22005931   Genome-wide association analysis of age of onset of Alzheimer's disease.

  22047634   Alzheimer's Disease Neuroimaging Initiative: A review of articles published since its inception.

  22089642   Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.

  22159054   A comprehensive genetic association study of Alzheimer disease in African Americans.

  22209813   Sparse reduced-rank regression reveals genetic associations with voxel-wise longitudinal phenotypes in Alzheimer's disease.

  22279548   Genetic signatures of exceptional longevity in humans.

  22430674   A genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.

  22445811   Genetic variants influencing human aging from genome-wide association studies of late-onset Alzheimer's disease (LOAD) (GWAS).

  22492993   C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.

  22499766   The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.

  22550605   Promising genetic biomarkers of preclinical Alzheimer's disease: impact of APOE and TOMM40 on brain integrity.

  22588700   Genetics of coronary artery disease in the 21st century.

  22694956   Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.

  22710912   TOMM40, APOE, and APOC1 in primary progressive aphasia and frontotemporal dementia.

  22911757   Association study of candidate gene polymorphisms with amnestic mild cognitive impairment in a Chinese population.

  23001569   Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.

  23040522   Apolipoprotein E and familial longevity.

  23100282   Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

  23193196   Assessment and separation of polygenic variations captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.

  23207651   A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.

  23288655   Association of TOMM40 polymorphisms with late-onset Alzheimer's disease in a Northern Han population.

  23546992   TOMM40 polymorphisms in Italian patients with Alzheimer's disease and frontotemporal dementia.

  23573206   Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort.

  23925498   Genetics of healthy aging and longevity.

  24176626   Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population.

  24244950   Meta‐analysis of genetic variants associated with human exceptional longevity.

  24270849   Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data.

  24530172   The CR1, ABCA7 and APOE genes influence the characteristics of cognitive impairment in Alzheimer's disease.

  24549102   TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder.

  24688116   Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

  24755620   Overrepresentation of glutamate signaling in Alzheimer's disease: enrichment of network pathways using meta-analysis of genome-wide association studies.

  24788522   Genome-wide genetic variation at the CELF1 locus (CUGBP, elav-like family member 1 gene) is associated with Alzheimer's disease and obesity.

  24868529   The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms.

  24924924   Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population.

  24932356   Genetics of coronary artery disease: an update.

  24936253   12q24 locus association with type 1 diabetes: SH2B3 or ATXN2?

  25132797   Using current data to define new approach in age related macular degeneration: need to accelerate translational research.

  25304313   No evidence of association between variant rs2075650 in lipid metabolism-related locus APOE/TOMM40 and advanced age-related macular degeneration in Han Chinese population.

  25469254   Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus.

  25542012   Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.

  25670335   Association of GWAS loci of Alzheimer's disease with MRI markers of brain aging.

  26154020   A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia.

  26171154   Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke.

  26238946   Association of genetic variants with dyslipidemia.

  26444770   Structural neuroimaging genetic interactions in Alzheimer's disease.

  26572157   Meta-analysis of the rs2075650 polymorphism and risk of Alzheimer disease.

  26576771   Combined genome-wide associations of CSF Aβ-42 and simple network properties highlight novel risk factors for Alzheimer's disease.

  26677855   Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.

  26680604   Polygenic analysis of late-onset Alzheimer's disease in mainland China.

  26683835   Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study.

  26727462   Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study.

  26795201   Associations Between Genetic Variants in 19p13 and 19q13 Regions and Susceptibility to Alzheimer Disease: A Meta-Analysis.

  26833246   New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

  26847647   Experimental Biology for the Identification of Causal Pathways in Atherosclerosis.

  26892960   From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease.

  26926881   Distinct effects of folate pathway genes MTHFR and MTHFD1L on ruminative response style: a potential risk mechanism for depression.

  26950853   Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium.

  26956984   Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank.

  26993346   Genetic risk factors for posterior cortical atrophy variant of Alzheimer's disease.

  27004735   Immunochip analysis identifies association of the RAD50/IL13 region with human longevity.