SNP information rs7412

Research and publications:

  2992507   Isolation and characterisation of a variant allele of the gene for human apolipoprotein E.

  3243553   Genotyping and sequence analysis of apolipoprotein E isoforms.

  6300187   Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia.

  6323533   A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1.

  8488843   Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia

  8664327   Characterization of a novel variant of apolipoprotein E, E2 Fukuoka (Arg-224 --> Gln) in a hyperlipidemic patient with xanthomatosis.

  9649566   Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2.

  15113403   Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis

  15157284   Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes

  15172743   ApoE genotype accounts for the vast majority of AD risk and AD pathology

  16103896   An association study of 43 SNPs in 16 candidate genes with atorvastatin response.

  16143024   Polymorphisms in the apolipoprotein A5 (APOA5) gene and type III hyperlipidemia.

  16603077   APOE and STH loci variations and Alzheimer's disease

  17048007   Association of warfarin dose with genes involved in its action and metabolism

  17289397   Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin.

  17356695   Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality

  17357073   Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol

  17434289   Comprehensive analysis of APOE and selected direct markers of late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association.

  17456829   Evaluation of genetic factors for warfarin dose prediction

  17658295   Association of ApoE genetic variants with obstructive sleep apnea in children.

  17672902   Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes

  17903299   A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

  18034366   Lack of replication of genetic associations with human longevity

  18216863   Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families

  18254975   Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat

  18275964   Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study

  18378515   APOE/C1/C4/C2 hepatic control region polymorphism influences plasma apoE and LDL cholesterol levels

  18513389   New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  18596683   Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans

  18603647   Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response

  18823527   Genome-wide association study of late-onset Alzheimer's disease using pooled DNA.

  18941475   About Jim Watson's APOE status: Genetic information is hard to hide.

  18974842   Gender differences in genetic risk profiles for cardiovascular disease

  18976728   Genome-wide association analysis identifies putative Alzheimer's disease susceptibility loci in addition to APOE

  19001172   Analysis of the National Institute on Aging Family Study of Late-Onset Alzheimer's Disease: Impact of Additional Loci.

  19014573   Application of two machine learning algorithms to genetic association studies in the presence of covariates

  19058936   A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females

  19118814   Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19172988   The complex interaction between APOE promoter and AD: an Italian case-control study

  19262956   The GAB2 gene does not alter the risk of Alzheimer's disease in Spanish APOE 4 carriers.

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19285141   Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response

  19299407   Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample

  19336475   Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk

  19377787   Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals

  19501493   A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study

  19541455   Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients

  19554612   APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure

  19602472   Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study

  19667110   Identification of genetic variants associated with response to statin therapy

  19668339   Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel Alzheimer's disease susceptibility genes.

  19756043   A simple and efficient algorithm for genome-wide homozygosity analysis in disease

  19766542   FAS gene, brain volume and disease progression in Alzheimer's disease.

  19787382   Introduction to the DISRUPT postprandial database: subjects, studies and methodologies

  19802338   Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replicatio

  19818961   Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm

  19884647   Air pollution, obesity, genes and cellular adhesion molecules

  19913121   Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip

  19936222   Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis

  19951432   Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease

  20031551   Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.

  20031563   Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study.

  20031582   Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort.

  20082485   Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women

  20100581   Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

  20167577   Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk

  20308031   Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer

  20381870   Progression of geographic atrophy and genotype in age-related macular degeneration

  20406466   Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

  20429872   Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study

  20451875   Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Key goals, progress, and genetics roadmap.

  20467002   Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls

  20498921   APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men

  20549395   Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies

  20565774   Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project

  20569235   HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging

  20663622   A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India

  20682755   A pilot study of gene/gene and gene/environment interactions in Alzheimer disease

  20734064   A large-scale candidate gene association study of age at menarche and age at natural menopause.

  20832063   Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study

  20838585   Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.

  20885792   Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.

  21045241   Age-related macular degeneration: genetic and environmental factors of disease.

  21054877   Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

  21123754   Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.

  21146954   Genes and abdominal aortic aneurysm

  21215387   IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children.

  21228733   Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients.

  21263195   The APOE haplotype associated with decreased β4 expression increases the risk of late-onset Alzheimer's disease.

  21285406   Low-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study.

  21379329   Genome-wide association of late-onset familial Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.

  21418511   Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.

  21441355   Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants.

  21450715   High-dimensional pharmacogenetic prediction of a continuous trait using machine learning techniques with application to warfarin dose prediction in African Americans.

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21498624   Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people.

  21547229   Neuroimaging indicators as endophenotypes in Alzheimer's disease.

  21597005   An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.

  21645382   A note on the use of the generalized odds ratio in meta-analysis of association studies involving bi- and tri-allelic polymorphisms.