SNP information rs4420638

Research and publications:

  17474819   A high-density genome-wide association study indicates that APOE is a major susceptibility gene for sporadic late-onset Alzheimer's disease.

  17998437   Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.

  18161859   Does APOE explain the link between Alzheimer's disease and chromosome 19q13?

  18179892   Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

  18193044   Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

  18262040   LDL-cholesterol concentrations: a genome-wide association study.

  18802019   Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.

  18852197   Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants

  18941475   About Jim Watson's APOE status: Genetic information is hard to hide.

  18976728   Genome-wide association analysis identifies putative Alzheimer's disease susceptibility loci in addition to APOE

  19060906   Common variants at 30 loci contribute to polygenic dyslipidemia.

  19060910   Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

  19161620   An open access database of genome-wide association results

  19197348   Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae

  19204163   GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results.

  19265542   Performance of random forest when SNPs are in linkage disequilibrium.

  19336475   Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk

  19336575   Genetic analysis of coronary artery disease single-nucleotide polymorphisms in diabetic nephropathy.

  19389868   The coronary artery disease SNP, rs4420638, is associated with diabetic nephropathy rather than end-stage renal disease.

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19557197   NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium

  19567438   Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

  19569043   Genome-wide association studies and the genetic dissection of complex traits

  19729614   Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk.

  19750184   Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

  19756043   A simple and efficient algorithm for genome-wide homozygosity analysis in disease

  19773416   A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women.

  19818961   Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm

  19951432   Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease

  20018036   Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.

  20031591   Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.

  20236449   Genetics of Alzheimer disease in the pre- and post-GWAS era.

  20309761   Genotype-based risk and pharmacogenetic sampling in clinical trials.

  20339536   Genome-wide association of lipid-lowering response to statins in combined study populations.

  20442857   Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.

  20460622   Genome-wide analysis of genetic loci associated with Alzheimer disease

  20498921   APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men

  20529013   APOE is not associated with Alzheimer disease: a cautionary tale of genotype imputation.

  20594621   Genetic architecture of Alzheimer's disease: beyond APP, PSEN and APOE.

  20679960   Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.

  20691829   Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.

  20839009   Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica.

  20864672   Genetic variants influencing circulating lipid levels and risk of coronary artery disease.

  20972250   Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.

  21041806   Genetic determinants of plasma triglycerides.

  21118897   Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population.

  21124753   Alzheimer's disease: diagnosis, prognosis and path to prevention.

  21127830   Genetic associations in diabetic nephropathy: a meta-analysis.

  21146954   Genes and abdominal aortic aneurysm

  21149302   Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population.

  21217833   A knowledge-based weighting framework to boost the power of genome-wide association studies.

  21300955   Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.

  21460841   Common variants MS4A4/MS4A6E, CD2AP, CD33, and EPHA1 are associated with late-onset Alzheimer's disease.

  21466885   Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent.

  21537386   Using In silico LD aggregation and meta-analysis of genome-wide datasets as a complementary tool to explore and validate new potential biomarkers in Alzheimer's disease.

  21537449   Genome-wide association analysis suggests that ACE is a risk factor for Alzheimer's disease and does not replicate most candidates from the meta-analysis.

  21645382   A note on the use of the generalized odds ratio in meta-analysis of association studies involving bi- and tri-allelic polymorphisms.

  21672907   Application of a naive Bayes model to predict Alzheimer's disease from genome-wide data.

  21738485   Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.

  21804106   Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

  21825236   Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease.

  21829380   Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability.

  21853025   A bayesian method for evaluating and discovering disease loci associations.

  21860704   Implications of discoveries from genome-wide association studies in current cardiovascular practice.

  21862702   Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk.

  21875899   Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour.

  21937998   Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults.

  21943158   Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.

  22003152   Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.

  22005931   Genome-wide association analysis of age of onset of Alzheimer's disease.

  22022282   A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.

  22054870   A genome-wide scan for common variants affecting the rate of age-related cognitive decline.

  22073310   Association of genetic loci with blood lipids in the Chinese population.

  22159054   A comprehensive genetic association study of Alzheimer disease in African Americans.

  22195117   Evaluating de novo locus-disease discoveries in GWAS using the signal-to-noise ratio.

  22273362   Mining high-density genomic variant data to predict Alzheimer's disease risk.

  22291609   A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

  22368281   Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a).

  22425169   Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol.

  22492993   C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.

  22499766   The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.

  22567092   MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS.

  22623978   A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides.

  22958594   Golgi phosphoprotein 2 in physiology and in diseases.

  22972380   Investigation of genetic risk factors for chronic adult diseases for association with preterm birth

  22994408   Transferability and fine mapping of genome-wide associated loci for lipids in African Americans.

  23098650   Impact of variants within seven candidate genes on statin treatment efficacy.

  23100282   Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

  23101478   Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study.

  23119086   Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate.

  23150898   Evaluation of seven common lipid associated loci in a large Indian sib pair study.

  23236286   Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.

  23284720   Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study.

  23286790   Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study.

  23393188   Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells.

  23455636   Seven new loci associated with age-related macular degeneration.

  23588940   Association of polymorphisms modulating low-density lipoprotein cholesterol with susceptibility, severity, and progression of rheumatoid arthritis.

  23925498   Genetics of healthy aging and longevity.

  24274136   Biobanking across the phenome - at the center of chronic disease research.

  24386469   Using systems biology approaches to analyze genome-wide association studies of myocardial infarction and blood cholesterol in the Nurses' Health Study and the Health Workers Follow-up Study.