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Is asthma hereditary

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Asthma is a respiratory condition that involves inflammation of the airways and recurring episodes of breathing difficulties. These episodes, also known as asthma attacks, are caused by irritation of the inflamed airways. Allergic asthma, the most prevalent type of asthma, is triggered by allergens that prompt an allergic reaction when inhaled. Allergens are typically harmless substances that the immune system mistakenly perceives as harmful, such as pollen, dust, animal dander, and mold. The immune response results in asthma symptoms.

Roughly 50% of individuals impacted by asthma possess a genetic predisposition, which may include inherited genetic mutations or single nucleotide polymorphisms (SNPs) that heighten the likelihood of developing asthma, particularly when coupled with specific environmental factors.

Genes that are frequently associated with asthma are:

High levels of IgE, which are associated with early-onset asthma, are strongly linked to the gene ORMDL3 (ORMDL Sphingolipid Biosynthesis Regulator 3).

The αβ heterodimer of MHC class II, known as HLA-DQ(A1/B1), is present on antigen-presenting cells and plays a role in autoimmune disorders such as coeliac disease and type 1 diabetes mellitus. Additionally, mutations in this gene have been linked to the development of late-onset asthma.

Bronchial smooth muscle cells and lung fibroblasts exhibit robust expression of ADAM33 (A Disintegrin and Metalloproteinase 33), which plays a role in airway hyperresponsiveness and reduced lung function.

The gene Filaggrin plays a crucial role in preserving skin barriers, and its mutations are commonly associated with atopic dermatitis and ichthyosis Vulgaris. Such mutations not only heighten the likelihood of skin disorders but also exacerbate the risk of asthma and hay fever.

Some other genes that are often associated with this condition (not a complete list) are IL1RL1, which stands for Interleukin 1 Receptor Like 1 (receptor).

Interleukin-33 (cytokine) is also known as IL33.

SMAD3 is an intracellular signal transducer protein and a member of the SMAD family.

The receptor subunit known as IL2RB is the Interleukin 2 Receptor Subunit B.

SPINK5 is a multidomain serine protease inhibitor, also known as Serine Peptidase Inhibitor Kazal Type 5.

The receptor for Vitamin D is known as VDR (Vitamin D Receptor).

DPP10 is a membrane protein that is similar to dipeptidyl peptidase.

Ph.D. type zinc finger protein 11, also known as PHF11.

Human Leukocyte Antigen G (MHC) is also known as HLA-G.

Interleukin-13 (cytokine) is abbreviated as IL13.

The receptor known as GPR15 is a G protein-coupled receptor 15.

TLR2/4/6/9/10 are receptors known as Toll-Like Receptors 2, 4, 6, 9, and 10.

Numerous genes play a role in inflammation, immunity, and lung function. Any alterations or variations in these genes can impair their typical function, resulting in uncontrolled immune and inflammatory reactions (i.e., an overreaction), airway remodeling that reduces lung function, or heightened hyperresponsiveness.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Bronchial asthma and see a list of existing studies.

SNP polymorphisms related to the topic Bronchial asthma:

rs7216389The ORMDL3 gene is linked to asthma, which is poorly controlled with current medications.
rs1800925Interleukin-13 SNP rs1800925 variation associated with asthma and allergic rhinitis.
rs1295686IL13 gene polymorphism modifies the effect of tobacco smoke exposure on persistent wheezing and asthma in childhood.
rs2070874Genetic predisposition to childhood allergies and asthma.
rs1042713Associated with asthma exacerbations regardless of treatment regimen. 1.3-fold increased risk that inhaler use in children may exacerbate asthma.
rs2280089ADAM33 gene polymorphism identified as associated with asthma and rhinitis in adults.
rs2280090ADAM33 gene polymorphism identified as associated with asthma and rhinitis in adults.
rs612709ADAM33 gene polymorphism identified as associated with asthma and rhinitis in adults.
rs1837253A variant of the estrogen receptor I (ESR1) gene is associated with anorexia nervosa and eating disorders.
rs169470788-fold risk of developing allergic asthma.
rs116503548-fold risk of developing allergic asthma.
rs4950928
rs1051931
rs1805018
rs7009110
rs4833095
rs62026376
rs1438673
rs17294280
rs72699186
rs10197862
rs6754459
rs20541
rs2066960
rs848
rs17218161
rs2473967
rs16929097
rs7927044
rs12570188
rs9815663
rs4658627
rs7328278
rs10521233
rs2303067
rs17334242
rs4986790
rs4986791
rs1801105
rs574174
rs44707
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rs569108
rs324981
rs1154404
rs2074190
rs9910408
rs2240017
rs2241712
rs2278206
rs4378650
rs12603332
rs4794067
rs8067378
rs6591255
rs3024492
rs3024496
rs3802780
rs1978331
rs11569562
rs1446495
rs3918396
rs689465
rs2407992
rs320995
rs2251746
rs2427837
rs8069176
rs2305480
rs4795400
rs3741240
rs12422149
rs3804100
rs11650680
rs8193036
rs1420101
rs7740529
rs10402876
rs366510
rs1334710
rs4959389
rs977785
rs1800896
rs11558538
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