SNP information rs7216389

Research and publications:

  18310477   ORMDL3 gene is associated with asthma in three ethnically diverse populations.

  18395550   A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.

  18439551   Genetic architecture of transcript-level variation in humans.

  19029000   Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.

  19133921   Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma.

  19175592   Asthma and atopy are associated with chromosome 17q21 markers in Chinese children.

  19426955   Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19714205   Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.

  19732864   Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

  19910030   Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans.

  20159242   Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.

  20187971   Modeling expression quantitative trait loci in data combining ethnic populations.

  20369022   Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.

  20372189   A sequence variant on 17q21 is associated with age at onset and severity of asthma.

  20503266   Allergy and glioma risk: test of association by genotype.

  20698975   Asthma-susceptibility variants identified using probands in case-control and family-based analyses.

  20816195   Analyses of shared genetic factors between asthma and obesity in children.

  20833654   Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes.

  21150878   Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.

  21337730   Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR.

  21966603   The search for genetic variants and epigenetics related to asthma.

  21985515   Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population.

  22069270   Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.

  22472724   Asthma and bronchodilator responsiveness are associated with polymorphic markers of ARG1, CRHR2 and chromosome 17q21.

  22732088   GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness.

  23028483   Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.

  23046476   Whole-exome sequencing of a pedigree segregating asthma.

  23157251   Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population.

  23755072   Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma.

  23886662   A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.

  23923021   From interaction to co-association --a Fisher r-to-z transformation-based simple statistic for real world genome-wide association study.

  24735179   Association between 17q12-21 variants and asthma in Japanese women: rs11650680 polymorphism as potential genetic marker for asthma.

  25256354   Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus.

  25331618   17q21 gene variation is not associated with asthma in adulthood.

  25729625   The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis.

  25768087   An ADAM33 polymorphism associates with progression of preschool wheeze into childhood asthma: a prospective case-control study with replication in a birth cohort study.

  25945796   Association between Variants in Atopy-Related Immunologic Candidate Genes and Pancreatic Cancer Risk.

  26069107   Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects.

  26125920   Correlation between the genetic polymorphism of ORMDL3 gene and asthma risk: a meta-analysis.

  26203825   Sequence variants on 17q21 are associated with the susceptibility of asthma in the population of Lahore, Pakistan.

  26575599   The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21.

  26603569   ORMDL3 contributes to the risk of atherosclerosis in Chinese Han population and mediates oxidized low-density lipoprotein-induced autophagy in endothelial cells.

  26886240   Association Between Gasdermin A and Gasdermin B Polymorphisms and Susceptibility to Adult and Childhood Asthma Among Jordanians.

  27411394   Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus.

  27658857   The genetic and epigenetic landscapes of the epithelium in asthma.

  27835674   Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21.

  28293925   Genetic Signatures of Asthma Exacerbation.

  28854703   Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases.

  28866644   Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants.

  29102067   Cat exposure in early life decreases asthma risk from the 17q21 high-risk variant.

  29296089   Elevated fractional exhaled nitric oxide and blood eosinophil counts are associated with a 17q21 asthma risk allele in adult subjects.

  30647901   Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review.

  31929190   Decreased sphingolipid synthesis in children with 17q21 asthma-risk genotypes.

  32444308   ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization.

  32496997   Association between Gasdermin A, Gasdermin B Polymorphisms and Allergic Rhinitis Amongst Jordanians.

  33157959   Asthma susceptible genes in children: A meta-analysis.

  33810791   Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case-control study.

  33963941   Association of Gasdermin B Gene GSDMB Polymorphisms with Risk of Allergic Diseases.

  33987892   Innate IL-23/Type 17 immune responses mediate the effect of the 17q21 locus on childhood asthma.

  34076350   The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi-institutional cohort.

  34244319   Prenatal tobacco exposure and risk of asthma and allergy outcomes in childhood.

  34919021   Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers.

  34982638   Association between 17q21 variants and asthma predisposition in Pashtun population from Pakistan.

  36034974   CYSLTR1 rs320995 (T927C) and GSDMB rs7216389 (G1199A) Gene Polymorphisms in Asthma and Allergic Rhinitis: A Proof-of-Concept Study.