SNP information rs4986791

Research and publications:

  10835634   TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.

  12124407   Toll-like receptor 4 polymorphisms and atherogenesis.

  16820586   Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery

  16954131   Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population.

  17667860   Toll-like receptor 2 polymorphism is associated with preterm birth.

  17699831   Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

  18172114   Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration.

  18298826   Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol.

  18307517   Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans

  18325643   Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results.

  18382655   Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome.

  18396467   Genetic variation and haplotype structures of innate immunity genes in eastern India.

  18422738   Study of Toll-like receptor gene loci in sarcoidosis.

  18549840   Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke.

  18753640   Toll-like receptor 3 and geographic atrophy in age-related macular degeneration.

  18975326   Toll-like receptor 2 variants are associated with acute reactive arthritis.

  18987746   Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.

  19085953   Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.

  19134200   No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.

  19277200   Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam.

  19543401   Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.

  19567509   Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes

  19586676   Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.

  20011079   Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan.

  20016852   Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.

  20026892   Association of the Toll-like receptor gene with Crohn's disease in Koreans.

  20463618   Role of polymorphic variants as genetic modulators of infection in neonatal sepsis

  20492496   Significant association between toll-like receptor gene polymorphisms and gallbladder cancer.

  20525286   Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.

  20577092   Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis.

  20671584   Toll-like receptor 4 gene polymorphisms show no association with the risk of clinical or angiographic restenosis after percutaneous coronary intervention.

  21081146   Impact of Toll-like receptor 4 polymorphisms on risk of cancer.

  21159925   Toll-like receptor 4 gene (TLR4), but not TLR2, polymorphisms modify the risk of tonsillar disease due to Streptococcus pyogenes and Haemophilus influenzae.

  21179534   Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome.

  21219635   Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population.

  21283657   Gallbladder cancer predisposition: a multigenic approach to DNA-repair, apoptotic and inflammatory pathway genes.

  21298446   Genetic variants in TLR2 and TLR4 are associated with markers of monocyte activation: the Atherosclerosis Risk in Communities MRI Study.

  21385363   Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study

  21466684   Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients.

  21483748   Influence of polymorphisms in innate immunity genes on susceptibility to invasive aspergillosis after stem cell transplantation

  21708280   Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis

  21776015   Toll-like receptor 4 region genetic variants are associated with susceptibility to melioidosis.

  21792899   Toll-like receptor genes and their association with colon and rectal cancer development and prognosis.

  21837802   Confirmation of an association between single nucleotide polymorphisms in the VDR gene with respiratory syncytial virus related disease in South African children.

  21852947   Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.

  21867552   Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites.

  21920464   Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer.

  22025579   High-throughput retina-array for screening 93 genes involved in inherited retinal dystrophy.

  22194275   Histological and genetic studies in patients with bicuspid aortic valve and ascending aorta complications.

  22251849   The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study.

  22300618   Toll-like 4 receptor variant, Asp299Gly, and reduced risk of hemorrhagic cystitis after hematopoietic stem cell transplantation.

  22301633   Toll-like receptor 1 polymorphisms increase susceptibility to candidemia.

  22348075   Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants.

  22359464   Are Toll-like receptor gene polymorphisms associated with prostate cancer?

  22427729   Inherited variation in pattern recognition receptors and cancer: dangerous liaisons?

  22494793   Innate immunity gene single nucleotide polymorphisms and otitis media.

  22524430   Genetics of longevity. data from the studies on Sicilian centenarians.

  22529866   Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection.

  22645142   Variants of Toll-like receptor 4 predict cardiac recovery in patients with dilated cardiomyopathy.

  22901274   Genetic variation in the TNF receptor-associated factor 6 gene is associated with susceptibility to sepsis-induced acute lung injury.

  22984424   Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis.

  23071570   Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level.

  23084080   The TLR4 gene polymorphisms and susceptibility to cancer: a systematic review and meta-analysis.

  23086128   Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer.

  23112821   Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data.

  23135962   CD14 and IL6 polymorphisms are associated with a pro-atherogenic profile in young adults with acute myocardial infarction.

  23144702   Candidate human genetic polymorphisms and severe malaria in a Tanzanian population.

  23151015   Toll-like receptor 3 gene polymorphisms and severity of pandemic A/H1N1/2009 influenza in otherwise healthy children.

  23161283   SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis?

  23272070   Toll-like receptor 4 sequence variants and late-onset Alzheimer's disease.

  23289617   Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.

  23316245   The host genetic diversity in malaria infection.

  23390954   Three multiplex snapshot assays for SNP genotyping in candidate innate immune genes.

  23417289   Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection.

  23459936   Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

  23582962   Progress in understanding the genetics of bronchopulmonary dysplasia.

  23776356   Allergic rhinitis and genetic components: focus on Toll-like receptors (TLRs) gene polymorphism.

  23867959   Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants.

  24028589   TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk.

  24176007   Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population.

  24176535   Polymorphism of Toll-like receptor 4 gene in bipolar disorder.

  24446182   Correlation between genetic polymorphisms within IL-1B and TLR4 genes and cancer risk in a Russian population: a case-control study.

  24447403   TLR4 polymorphism is not associated with biopsy proven giant cell arteritis.

  24833854   Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy.

  24851022   Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4.

  24883015   Toll-like receptor 4 polymorphisms and their haplotypes modulate the risk of developing diabetic retinopathy in type 2 diabetes patients.

  24943594   Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.

  24959291   Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in ovarian cancers.

  25000179   Genetic polymorphisms and sepsis in premature neonates.

  25213166   An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis.

  25360682   Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.

  25423559   The role of Toll-like receptor polymorphisms in acute pancreatitis occurrence and severity.

  25454804   Genetic polymorphisms of innate and adaptive immunity as predictors of outcome in critically ill patients.

  25516666   Cytokine production in patients with cirrhosis and TLR4 polymorphisms.

  25542762   Poststroke fatigue: hints to a biological mechanism.

  25560985   Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases.

  25741362   Use of pharmacogenomics in pediatric renal transplant recipients.

  25889916   Association of polymorphisms in Toll-like receptors 4 and 9 with risk of pulmonary tuberculosis: a meta-analysis.

  26023918   Association between TLR2 and TLR4 Gene Polymorphisms and the Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis.