SNP information rs2305480

Research and publications:

  18923164   Effect of 17q21 variants and smoking exposure in early-onset asthma.

  19458352   Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20372189   A sequence variant on 17q21 is associated with age at onset and severity of asthma.

  20848476   Genetic predictors of medically refractory ulcerative colitis.

  20860503   A large-scale, consortium-based genomewide association study of asthma.

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21425313   Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.

  21506939   Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort.

  21543792   Genetics of complex airway disease.

  21907864   Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.

  22069270   Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.

  22190364   Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

  22370936   Genetic variants on 17q21 are associated with asthma in a Han Chinese population.

  22469062   Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma-like symptoms.

  22936693   Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.

  23028483   Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.

  23154084   Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.

  23755072   Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma.

  23886662   A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.

  25256354   Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus.

  26493291   Polymorphisms of RAD50, IL33 and IL1RL1 are associated with atopic asthma in Chinese population.

  26534891   Genetic effects of multiple asthma loci identified by genomewide association studies on asthma and spirometric indices.

  26786172   Heritability and confirmation of genetic association studies for childhood asthma in twins.

  27163155   Polymorphisms and haplotypes of the chromosome locus 17q12-17q21.1 contribute to adult asthma susceptibility in Slovenian patients.

  27336838   Blood and gut eQTLs from an anti-TNF-resistant Crohn's disease cohort inform genetic association loci for IBD.

  27658857   The genetic and epigenetic landscapes of the epithelium in asthma.

  28347358   Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.

  28461288   A meta-analysis of genome-wide association studies of asthma in Puerto Ricans.

  29330013   A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis.

  32380068   Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.

  33535024   Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.

  33963941   Association of Gasdermin B Gene GSDMB Polymorphisms with Risk of Allergic Diseases.

  33987892   Innate IL-23/Type 17 immune responses mediate the effect of the 17q21 locus on childhood asthma.

  35088123   Genetics of rheumatoid arthritis.