SNP information rs2070874

Research and publications:

  15570643   Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis.

  15660293   No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.

  16449530   Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma

  17303794   Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.

  17327408   Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival

  17713557   Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.

  18056382   Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.

  18454680   Genetic basis for adverse events after smallpox vaccination.

  18538381   Clinical and genetic risk factors of self-reported penicillin allergy.

  18633131   Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era

  18676870   Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China

  18781131   Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma

  19058298   Promoter polymorphisms of IL2, IL4, and risk of gastric cancer in a high-risk Chinese population.

  19066394   Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma

  19254294   Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort.

  19356949   Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies

  19468064   Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

  19578876   The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.

  19773451   Role of inflammation gene polymorphisms on pain severity in lung cancer patients

  19840389   Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.

  19933216   The COPD genetic association compendium: a comprehensive online database of COPD genetic associations

  20015396   Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.

  20032229   Prediction of functional impairment and remission in rheumatoid arthritis patients by biochemical variables and genetic polymorphisms.

  20332709   Analysis of the association of IL-3, IL-4, IL-5, IL-9 and IL-13 polymorphisms with Graves' disease.

  20406895   Genetic variants in inflammation pathway genes and asthma in glioma susceptibility

  20525402   Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study

  20711808   Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists

  20807397   The landscape of human genes involved in the immune response to parasitic worms.

  20811626   Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer

  20952689   Cytokine polymorphisms in Th1/Th2 pathway genes, body mass index, and risk of non-Hodgkin lymphoma

  21103062   Unifying candidate gene and GWAS Approaches in Asthma.

  21160888   Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions

  21211660   Sequence variation in the IL4 gene and resistance to Trypanosoma cruzi infection in Bolivians.

  21320344   Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

  21387019   Differences in candidate gene association between European ancestry and African American asthmatic children.

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21501388   Association between interleukin-4 gene polymorphisms and intracerebral haemorrhage in Korean population.

  21708280   Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis

  21846818   Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality.

  22113576   Polymorphisms in immune function genes and non-Hodgkin lymphoma survival.

  22180854   Polymorphisms in Th1/Th2 cytokine genes, hormone replacement therapy, and risk of non-Hodgkin lymphoma.

  22230215   Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study.

  22357570   The Peru Urban versus Rural Asthma (PURA) Study: methods and baseline quality control data from a cross-sectional investigation into the prevalence, severity, genetics, immunology and environmental factors affecting asthma in adolescence in Peru

  22377791   Association of genetic polymorphisms of interleukins with new-onset diabetes after transplantation in renal transplantation.

  22528336   Association study of interleukin-4 polymorphisms with paranoid schizophrenia in the Polish population: a critical approach.

  22573572   Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA II study).

  22654556   Graves' ophthalmopathy: a review of immunogenetics.

  22824342   Association of polymorphisms of cytokine and TLR-2 genes with long-term immunity to hepatitis B in children vaccinated early in life.

  22844404   Evidence of associations between cytokine genes and subjective reports of sleep disturbance in oncology patients and their family caregivers.

  22884982   Polymorphisms in the IL4 gene, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.

  23110190   IL-4 haplotype -590T, -34T and intron-3 VNTR R2 is associated with reduced malaria risk among ancestral indian tribal populations.

  23459936   Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

  23572437   Three common polymorphisms in the IL-4 gene and cancer risk: a meta-analysis involving 5,392 cases and 6,930 controls.

  23651591   Association of polymorphisms in the interleukin-4 gene with response to hepatitis B vaccine and susceptibility to hepatitis B virus infection: a meta-analysis.

  23663310   Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.

  24075353   Gene polymorphisms of Interleukin-4 in allergic rhinitis and its association with clinical phenotypes.

  24179683   IL-4 Receptor α Polymorphisms May Be a Susceptible Factor for Work-Related Respiratory Symptoms in Bakery Workers.

  24309190   Genetics of new-onset diabetes after transplantation.

  24463336   Association of interleukin-4 genetic polymorphisms with sporadic Alzheimer's disease in the Chinese Han population.

  24502445   Cytokine candidate genes predict the development of secondary lymphedema following breast cancer surgery.

  24735657   The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition.

  24963371   The ontology of genetic susceptibility factors (OGSF) and its application in modeling genetic susceptibility to vaccine adverse events.

  25238536   Association of cytokines in individuals sensitive and insensitive to dust mites in a Brazilian population.

  25295591   Role of IL-4 gene polymorphisms in HBV-related hepatocellular carcinoma in a Chinese population.

  25308608   Interleukin-4 and interleukin-10 polymorphisms and antituberculosis drug-induced hepatotoxicity in Chinese population.

  25747600   Associations of IL-2 and IL-4 Expression and Polymorphisms With the Risks of Mycoplasma pneumoniae Infection and Asthma in Children.

  25768087   An ADAM33 polymorphism associates with progression of preschool wheeze into childhood asthma: a prospective case-control study with replication in a birth cohort study.

  25935236   Genotype combinations of two IL4 polymorphisms influencing IL-4 plasma levels are associated with different risks of severe malaria in the Malian population.

  26504066   Contribution of Interleukin-4 Genotypes to Lung Cancer Risk in Taiwan.

  26524966   The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis.

  26667837   Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium.

  26870349   Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients.

  26986131   Human Cytokine Genetic Variants Associated With HBsAg Reverse Seroconversion in Rituximab-Treated Non-Hodgkin Lymphoma Patients.

  27051588   Analysis of single nucleotide polymorphisms implicate mTOR signalling in the development of new-onset diabetes after transplantation.

  27074324   PRELIMINARY REPORT ON THE PUTATIVE ASSOCIATION OF IL10 -3575 T/A GENETIC POLYMORPHISM WITH MALARIA SYMPTOMS.

  27177030   Pro-inflammatory cytokines and their epistatic interactions in genetic susceptibility to schizophrenia.

  27195298   Association between Polymorphisms in Interleukins 4 and 13 Genes and Chronic Periodontitis in a Han Chinese Population.

  27247849   Genetic variation and cognitive dysfunction in opioid-treated patients with cancer.

  27417569   Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases.

  27419029   Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population.

  27460425   Precision assessment of heterogeneity of lymphedema phenotype, genotypes and risk prediction.

  27462317   Association Study for 26 Candidate Loci in Idiopathic Pulmonary Fibrosis Patients from Four European Populations.

  27570418   Hepatitis-related hepatocellular carcinoma: Insights into cytokine gene polymorphisms.

  27624002   Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children.

  27725770   Genetic dissection of host immune response in pneumonia development and progression.

  27896277   Prediction of Bacillus Calmette-Guerin Response in Patients with Bladder Cancer after Transurethral Resection of Bladder Tumor by Using Genetic Variation Based on Genomic Studies.

  28036156   Interleukin-4 cytokine single nucleotide polymorphisms in kawasaki disease: a case-control study and a review of knowledge.

  28051794    Effects of interleukin-4 and interleukin-12B gene polymorphisms on hepatitis B virus vaccination.

  28142034   Association of IL4, IL13, and IL4R polymorphisms with gastrointestinal cancer risk: A meta-analysis.

  28289589   Polymorphism of the IL13 gene may be associated with Uterine leiomyomas in Slovenian women.

  28656227   Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis.

  28950434   The IL-4 rs2070874 polymorphism may be associated with the severity of recurrent viral-induced wheeze.

  29034061   Association between four SNPs in IL-4 and the risk of gastric cancer in a Chinese population.

  29298992   Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases.

  30130760   Genes Regulating Immune Response and Amelogenesis Interact in Increasing the Susceptibility to Molar-Incisor Hypomineralization.

  30939298   Interleukin gene polymorphisms in chronic periodontitis: A case-control study in the Indian population.

  31264107   Association between interleukin-4 and interleukin-10 single nucleotide polymorphisms and multiple sclerosis among Iraqi patients.

  31475028   Host Genetic Determinants of Hepatitis B Virus Infection.

  32077194   Certain interleukin polymorphisms might influence predisposition to lung cancer: A meta-analysis of 35 published studies.