Upload the DNA data file of the test

23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage

and get an enhanced
personalized health report
free without registration

Files accepted .txt, .csv, .zip, .csv.gz

File data is not stored on the server

Psoriasis is a genetic disease

If you tested your DNA with a personal genomics service like 23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage or another testing company, you can learn more about your risk factors for hundreds of diseases. By clicking the button above ⬆️, you can upload your raw DNA data file and receive a personalized 250-page health report with research links that is the most comprehensive.

It is beneficial to comprehend the genetic impact on the molecular mechanisms and pathways that could trigger psoriasis for the purpose of preventing and treating the ailment. Additionally, this knowledge can aid in pinpointing potential drug targets.

Numerous gene mutations are potentially implicated in the development of psoriasis. Consequently, ongoing research endeavors aim to elucidate the immune system and inflammatory response mechanisms and impact of these genes.

HLA-Cw6 is a gene that is strongly linked to psoriasis, particularly guttate psoriasis and type I early-onset psoriasis.

Compared to other races or ethnicities, the gene is more prevalent among individuals who are white. Those who possess the gene have a higher likelihood of encountering stress, obesity, and strep throat.

Individuals possessing this gene and developing psoriasis are prone to encountering amplified symptoms on their torso, limbs, and legs. Additionally, they have a higher probability of experiencing the Koebner phenomenon.

A mutation in the gene CARD14, which has been identified by trusted researchers, seems to be involved in the onset of psoriasis.

Psoriasis may occur when specific environmental triggers are present alongside changes in this gene, which can cause increased inflammation.

It seems that CARD14 has a part to play in the development of pustular psoriasis.

Psoriasis development is heavily influenced by the PSORS1 locus, which is estimated to be responsible for 50% of all cases due to genetic susceptibility. This locus is situated on chromosome 6 within the major histocompatibility complex (MHC) and plays a crucial role in both immune system response and the encoding of psoriasis-associated skin proteins.

Psoriasis vulgaris is strongly associated with three genes located in this locus, namely:

The HLA-C gene, specifically the HLA-Cw6 variant, is responsible for producing the MHC class 1 protein.

The overexpressed coiled protein is encoded by the gene CCHCR1, specifically the WWC variant.

The overexpressed corneodesmosin protein is encoded by the CDSN gene variant allele 5.

The potential role of interleukin-12 (IL-12) subunit beta (IL-12B) and IL-23R in the development of psoriasis is currently under investigation, as they have been strongly linked to the condition. These interleukin genes are involved in the up-regulation pathway for inflammation-related genes, including tumor necrosis factor-α and nuclear factor KB.

New methods of treating and preventing psoriasis are emerging as scientists gain further insight into the role of genes in the condition.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Psoriasis and see a list of existing studies.

SNP polymorphisms related to the topic Psoriasis:

rs1265159There is a 22.6-fold increased risk of psoriasis.
rs587777763The ZNF750 promoter sequence variant is associated with familial psoriasis.
rs3212227IL12B gene polymorphism is associated with psoriasis and tuberculosis.
rs3213094IL12B gene polymorphism is associated with psoriasis and tuberculosis.
rs144475004A significant (6-fold) increase in the risk of developing psoriasis, at least in Asians.
rs281875215A rare mutation of the CARD14 gene on chromosome 17 demonstrating autosomal dominantly inherited psoriasis.
rs17728338A genetic marker for the development or presence of psoriatic arthritis in psoriasis patients.
rs2546890
rs7927894
rs12720356
rs2201841
rs2523454
rs3134792
rs12586317
rs240993
rs1076160
rs4085613
rs280519
rs1265181
rs4649203
rs8016947
rs458017
rs702873
rs33980500
rs12191877
rs842636
rs6809854
rs2082412
rs4112788
rs465969
rs12580100
rs2066808
rs10782001
rs495337
rs4795067
rs887466
rs12634229
rs6661961
rs13015714
rs27524
rs479844
rs878860
rs10995251
rs4722404
rs593982
rs2164983
rs7613051
rs176095
rs3126085
rs1444418
rs7130588
rs4406273
rs387907240
rs281875214
rs281875212
rs281875213
rs4379333
rs734232
rs6887695
rs7993214
rs6701216
rs3803369
rs610604
rs10484554
rs3853601
en
|
de
|
fr
|
es
|
it
|
ua
|
ru

Support