SNP information rs12720356

Research and publications:

  15657875   Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

  18270328   Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.

  19249008   Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.

  19434718   Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.

  19604093   Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients

  19653082   Compelling evidence for combined polymorphisms of the tyrosine kinase 2 gene and signal transducer and transcription activator 3 gene as a DNA-based biomarker of susceptibility to Crohn's disease in a Japanese population.

  20953190   A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

  21085059   Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation.

  21102463   Genome-wide meta-analysis increases the number of confirmed susceptibility loci for Crohn's disease to 71.

  21140222   Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases.

  21297633   Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

  22988944   Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases.

  23000200   TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.

  23028907   Limited evidence for parent-of-origin effects in inflammatory bowel disease associated loci.

  23886662   A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.

  24033266   A systematic approach to assessing the clinical significance of genetic variants.

  24069534   Genetics of psoriasis and pharmacogenetics of biological drugs.

  24175098   The role of 39 psoriasis risk variants on age of psoriasis onset.

  24653663   Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations.

  25541970   The influence of the CHIEF pathway on colorectal cancer-specific mortality.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25849893   TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

  26338038   Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.

  26613086   Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis.

  26974007   Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.

  26980740   Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis.

  27810495   Psoriasis risk SNPs and their association with HIV-1 control.

  28617847   The association between 38 previously reported polymorphisms and psoriasis in a Polish population: High predicative accuracy of a genetic risk score combining 16 loci.

  29728633   The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells.

  30888520   Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

  31434951   Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans.

  31577850   Paradoxical psoriasis induced by TNF-α blockade shows immunological features typical of the early phase of psoriasis development.

  33949620   Association of TYK2 polymorphisms with autoimmune diseases: A comprehensive and updated systematic review with meta-analysis.

  35470158   Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.