SNP information rs6887695

Research and publications:

  17236132   A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.

  18219280   Polymorphisms of the IL12B and IL23R genes are associated with psoriasis.

  18369459   A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.

  18383521   IL23R and IL12B polymorphisms in Spanish IBD patients: no evidence of interaction.

  18438406   Genetic determinants of ulcerative colitis include the ECM1 locus and five loci involved in Crohn's disease.

  18533027   Worldwide population differentiation at disease-associated SNPs

  18609743   Genetics of psoriasis and psoriatic arthritis: update and future direction.

  18800148   Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis.

  18936107   Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients.

  19035472   Investigation of association of the IL12B and IL23R genes with psoriatic arthritis.

  19140132   Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.

  19182814   New insights into the pathogenesis and genetics of psoriatic arthritis.

  19525279   Characterisation of psoriasis susceptibility locus 6 (PSORS6) in patients with early onset psoriasis and evidence for interaction with PSORS1.

  19705136   Genetic evidence for involvement of the IL23 pathway in Thai psoriatics.

  19838195   A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

  19953089   Differences in genetic background between active smokers, passive smokers, and nonsmokers with Crohn's disease.

  20606885   Genetics of psoriasis and psoriatic arthritis.

  20875477   Replication of association between interleukin-23 receptor (IL-23R) and its ligand (IL-12B) polymorphisms and psoriasis in the Chinese Han population.

  20953186   Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.

  21198744   The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype.

  21214922   Psoriasis prediction from genome-wide SNP profiles.

  21253534   The IL23R and IL12B SNPs and haplotypes are strongly associated with the risk of Crohn's disease in the New Zealand population.

  21333900   The role of genetics in IBS

  21487504   Immunopathogenesis of inflammatory bowel disease.

  21548950   Evaluation of 22 genetic variants with risk for Crohn's disease in an Ashkenazi Jewish population: a case-control study.

  21829393   Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

  22190364   Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

  22194214   Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes.

  22479607   Analysis of IL12B gene variants in inflammatory bowel disease.

  22739501   Resequencing of the IL12B gene in psoriasis patients with the rs6887695/rs3212227 risk genotypes.

  22984424   Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis.

  23093722   Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis.

  23164360   Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population.

  23297015   Meta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis.

  23564024   Association of IL-12B gene rs6887695 polymorphism with hereditary susceptibility and clinical characterization of psoriasis vulgaris in the Chinese Han population.

  23578145   Levels of interleukin-(IL)-12p40 are markedly increased in Brucellosis among patients with specific IL-12B genotypes.

  23955419   IL12B and IL23R gene SNPs in Japanese psoriasis.

  24069534   Genetics of psoriasis and pharmacogenetics of biological drugs.

  24175098   The role of 39 psoriasis risk variants on age of psoriasis onset.

  24859272   Genetic variations of IL-12B, IL-12Rβ1, IL-12Rβ2 in Behçet's disease and VKH syndrome.

  24957500   Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus.

  24971308   Genetic variations of cytokines and cytokine receptors in psoriasis patients from china.

  25133031   Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.

  25469793   Association of polymorphisms in interleukin (IL)-12A and -B genes with rheumatoid arthritis in a Chinese population.

  26103568   Association Study of IL-12B Polymorphisms Susceptibility with Ankylosing Spondylitis in Mainland Han Population.

  26663019   Genetic variations in interleukin-12B in allergic rhinitis.

  26678060   IL12B (p40) Gene Polymorphisms Contribute to Ustekinumab Response Prediction in Psoriasis.

  26698117   Polymorphisms in the Toll-Like Receptor and the IL-23/IL-17 Pathways Were Associated with Susceptibility to Inflammatory Bowel Disease in a Danish Cohort.

  26993061   Accounting for selection and correlation in the analysis of two-stage genome-wide association studies.

  27073425   Candidate gene polymorphisms and risk of psoriasis: A pilot study.

  27417569   Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases.

  28276258   An interleukin 12 B single nucleotide polymorphism increases IL-12p40 production and is associated with increased disease susceptibility in patients with relapsing-remitting multiple sclerosis.

  28289589   Polymorphism of the IL13 gene may be associated with Uterine leiomyomas in Slovenian women.

  28617847   The association between 38 previously reported polymorphisms and psoriasis in a Polish population: High predicative accuracy of a genetic risk score combining 16 loci.

  29389950   Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis.

  30206443   Genetic polymorphism in psoriasis and its meaning for the treatment efficacy in the future.

  30584776   Association of TNF, IL12, and IL23 gene polymorphisms and psoriatic arthritis: meta-analysis.

  30973927   Single nucleotide polymorphism analysis in interstitial cystitis/painful bladder syndrome.

  31114439   Ankylosing spondylitis: analysis of gene-gene interactions between IL-12β, JAK2, and STAT3 in Han Chinese and Algerian cohorts.

  32349161   Immunorelated gene polymorphisms associated with acute myeloid leukemia.

  32352837   IL-12B Polymorphisms Are Associated with the Presence of Premature Coronary Artery Disease and with Cardiovascular Risk Factors: The Genetics of Atherosclerotic Disease Mexican Study.

  32464244   Candidate polymorphisms and susceptibility to inflammatory bowel disease: A systematic review and meta-analysis.

  32666631   Interleukin-12B gene rs6887695 and rs2288831 polymorphisms are associated with an increased risk of ulcerative colitis development in Chinese Han population: A case-control study.

  32947150   Association between IL12B polymorphisms and inflammatory bowel disease in Caucasian population: A meta-analysis.

  33390082   The Polymorphisms of Interleukin-12B Gene and Susceptibility to Inflammatory Bowel Diseases: A Meta-analysis and Trial Sequential Analysis.

  33834388   Association of interleukin-12B rs6887695 with susceptibility to allergic rhinitis.

  34127053   Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review.

  35086377   Association between interleukin 12B and interleukin 23R gene polymorphisms and systemic lupus erythematosus: a meta-analysis.

  35567898   IL12B rs6887695 polymorphism and interaction with alcohol intake in the risk of ulcerative colitis in Japan.

  35814239   The Inflammatory Factor SNP May Serve as a Promising Biomarker for Acitretin to Alleviate Secondary Failure of Response to TNF-a Monoclonal Antibodies in Psoriasis.