SNP information rs280519

Research and publications:

  15657875   Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

  19440814   Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population.

  19653082   Compelling evidence for combined polymorphisms of the tyrosine kinase 2 gene and signal transducer and transcription activator 3 gene as a DNA-based biomarker of susceptibility to Crohn's disease in a Japanese population.

  19838195   A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

  20441431   Recent advances in the genetics of systemic lupus erythematosus.

  20933377   Recent findings on genetics of systemic autoimmune diseases.

  20953190   A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

  21140222   Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases.

  22046141   Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

  22121102   JAK/STAT/SOCS-signaling pathway and colon and rectal cancer.

  22536486   Lupus nephritis: an overview of recent findings.

  22592861   Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.

  22640752   The genetics of lupus: a functional perspective.

  22753952   Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.

  23227085   Genetics of SLE: functional relevance for monocytes/macrophages in disease.

  23326239   A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).

  24033266   A systematic approach to assessing the clinical significance of genetic variants.

  24175098   The role of 39 psoriasis risk variants on age of psoriasis onset.

  24653663   Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations.

  25034154   Clinical perspectives on lupus genetics: advances and opportunities.

  25147926   Cellular adhesion gene SELP is associated with rheumatoid arthritis and displays differential allelic expression.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25744728   Tyrosine kinase-2 gene polymorphism is associated with ulcerative colitis and Crohn's disease in the Turkish population.

  26294277   Genetic association and interaction between the IRF5 and TYK2 genes and systemic lupus erythematosus in the Han Chinese population.

  26980740   Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis.

  28704535   Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C.

  28846454   GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population.

  30171347   Comprehensive assessment of the association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis.

  31577850   Paradoxical psoriasis induced by TNF-α blockade shows immunological features typical of the early phase of psoriasis development.

  33583939   Polymorphisms in IRF5 and TYK2 Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population.

  33949620   Association of TYK2 polymorphisms with autoimmune diseases: A comprehensive and updated systematic review with meta-analysis.