SNP information rs4728142

Research and publications:

  17412832   Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

  18285424   Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.

  19440200   Identification of new SLE-associated genes with a two-step Bayesian study design

  19772658   Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation.

  19854706   Association of IRF5 polymorphisms with activation of the interferon alpha pathway.

  20169177   Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.

  20383147   Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.

  20453842   Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

  20479942   Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.

  20691091   Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data.

  20861862   Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.

  20933377   Recent findings on genetics of systemic autoimmune diseases.

  21297633   Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

  21437871   Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus.

  21471993   Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  22162633   Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes.

  22257839   A two-marker haplotype in the IRF5 gene is associated with inflammatory bowel disease in a North American cohort.

  22291604   A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.

  22407130   Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up.

  22440820   IRF5 polymorphism predicts prognosis in patients with systemic sclerosis.

  22544929   IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells.

  22936693   Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.

  23023776   European genetic ancestry is associated with a decreased risk of lupus nephritis.

  23236436   Gene-gene and gene-sex epistatic interactions of MiR146a, IRF5, IKZF1, ETS1 and IL21 in systemic lupus erythematosus.

  23300620   Genotype/phenotype analysis of 53 genetic polymorphisms associated with Crohn's disease.

  23372721   The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.

  23941291   Identification of three new cis-regulatory IRF5 polymorphisms: in vitro studies.

  23971939   IRF5, but not TLR4, DEFB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population.

  24871463   GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.

  24943672   Prediction of response to interferon therapy in multiple sclerosis.

  25205108   The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.

  25332064   An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3.

  25337792   Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population.

  26106387   Pathogenesis of Systemic Sclerosis.

  26398853   Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans.

  26606652   Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.

  26663301   Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.

  26857698   Genome-wide analysis of DNA methylation in multiple tissues in primary Sjögren's syndrome reveals regulatory effects of interferon-induced genes.

  27014188   Analysis of genetic susceptibility to Graves' disease in a cohort of patients of Italian origin.

  27156530   Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.

  27336838   Blood and gut eQTLs from an anti-TNF-resistant Crohn's disease cohort inform genetic association loci for IBD.

  28739976   Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

  29070082   Sex influences eQTL effects in SLE and genetic polymorphisms associated with Sjögren's syndrome.

  29375210   Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection.

  29476163   Genetic predictors of systemic sclerosis-associated interstitial lung disease: a review of recent literature.

  30711878   Genetic differences between primary progressive and relapsing-remitting multiple sclerosis: The impact of immune-related genes variability.

  31156624   Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.

  31469255   A genome-wide association and replication study of blood pressure in Ugandan early adolescents.

  31659207   Rare variants in non-coding regulatory regions of the genome that affect gene expression in systemic lupus erythematosus.

  31916109   Defining genetic risk factors for scleroderma-associated interstitial lung disease : IRF5 and STAT4 gene variants are associated with scleroderma while STAT4 is protective against scleroderma-associated interstitial lung disease.

  32464244   Candidate polymorphisms and susceptibility to inflammatory bowel disease: A systematic review and meta-analysis.

  33666161   Interferon regulatory factor 5 gene variants rs2004640 and rs4728142 are associated with carotid intima media thickness but not with cardiovascular events in rheumatoid arthritis.