SNP information rs744166

Research and publications:

  15657875   Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

  18587394   Genome-wide association identifies more than 30 different susceptibility loci for Crohn's disease.

  18978678   Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.

  19068216   Investigation of Crohn's disease risk loci in ulcerative colitis further determines their molecular relatedness.

  19557189   Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions

  19653082   Compelling evidence for combined polymorphisms of the tyrosine kinase 2 gene and signal transducer and transcription activator 3 gene as a DNA-based biomarker of susceptibility to Crohn's disease in a Japanese population.

  19776189   Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults.

  19915572   Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

  20109474   Genetic drivers of chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, DNA damage susceptibility and Crohn's disease in a New Zealand population.

  20159113   Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.

  20200543   STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility.

  20222910   Susceptibility loci identified by genome-wide association studies are associated with Crohn's disease in Canadian children.

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20392289   Genetic associations in type I interferon related pathways with autoimmunity.

  20405052   The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

  20454450   Evidence that STAT4 is a common autoimmune gene: rs7574865 is associated with Crohn's disease of the colon and early onset of the disease.

  20570966   Nonsecretory fucosyltransferase 2 (FUT2) status is associated with Crohn's disease.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  21152001   The association of 1q32 and STAT3 variants with ankylosing spondylitis suggests genetic overlap with Crohn's disease.

  21217814   Presymptomatic risk assessment for chronic non-communicable diseases.

  21247752   Revealing the genetic basis of multiple sclerosis: are we there yet?

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21430300   Genetic polymorphisms in inflammation pathway genes and prostate cancer risk.

  21487504   Immunopathogenesis of inflammatory bowel disease.

  21548950   Evaluation of 22 genetic variants with risk for Crohn's disease in an Ashkenazi Jewish population: a case-control study.

  21682861   Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving.

  21730793   The influence of risk alleles for Crohn's disease and smoking on the location of the disease.

  21752155   Genetic susceptibility to inflammation and colonic transit in lower functional gastrointestinal disorders: preliminary analysis.

  21830272   Different and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlation with pathogenesis.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  22065112   JAK2 rs10758669 variant in Crohn's disease: alteration of the intestinal barrier as one of the mechanisms of action.

  22095036   Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.

  22127647   A novel bayesian graphical model for genome-wide multi-SNP association mapping.

  22190364   Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

  22269120   Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease.

  22359581   Th17-related genes and celiac disease susceptibility.

  22479607   Analysis of IL12B gene variants in inflammatory bowel disease.

  23112570   Suggestive association between PLA2G12A single nucleotide polymorphism rs2285714 and response to anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration.

  23127549   Impact of STAT3 genetic variants on susceptibility to psoriatic arthritis and Behçet's disease.

  23300620   Genotype/phenotype analysis of 53 genetic polymorphisms associated with Crohn's disease.

  23326239   A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).

  23386860   Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.

  23611997   JAK1, but not JAK2 and STAT3, confers susceptibility to Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population.

  24081513   Association of single-nucleotide polymorphisms in the STAT3 gene with autoimmune thyroid disease in Chinese individuals.

  24244878   Fibrogenesis and fibrosis in inflammatory bowel diseases: Good and bad side of same coin?

  24419661   Combined effect of five single nucleotide polymorphisms related to IL23/Th17 pathway in the risk of psoriasis.

  24460100   A pilot study of IL-23R and STAT3 gene variants found no association with Hashimoto's thyroiditis in a Croatian population.

  24864251   rs744166 polymorphism of the STAT3 gene is associated with risk of gastric cancer in a Chinese population.

  24885273   Association between STAT3 gene polymorphisms and susceptibility to Crohn's disease: a case-control study in a Chinese Han population.

  25133031   Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.

  25286337   Associations between STAT3 rs744166 polymorphism and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.

  26063618   Association between STAT3 polymorphisms and cancer risk: a meta-analysis.

  26186918   STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer.

  26839145   Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy.

  27022745   Interaction between STAT3 gene polymorphisms and smoking on susceptibility to Crohn's disease: a case-control study in a Chinese Han population.

  27049718   Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.

  27336838   Blood and gut eQTLs from an anti-TNF-resistant Crohn's disease cohort inform genetic association loci for IBD.

  27499173   A technical application of quantitative next generation sequencing for chimerism evaluation.

  28381801   Association of Single Nucleotide Polymorphisms in STAT3, ABCB1, and ABCG2 with Stomatitis in Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib: A Retrospective Analysis in Japanese Patients.

  28420002   Associations between STAT Gene Polymorphisms and Psoriasis in Northeastern China.

  28521414   Association of FGFR2 rs2981582, SIRT1 rs12778366, STAT3 rs744166 gene polymorphisms with pituitary adenoma.

  28617847   The association between 38 previously reported polymorphisms and psoriasis in a Polish population: High predicative accuracy of a genetic risk score combining 16 loci.

  29027112   Field Synopsis and Re-analysis of Systematic Meta-analyses of Genetic Association Studies in Multiple Sclerosis: a Bayesian Approach.

  29228965   Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.

  29330562   Influence of genetic polymorphisms of IL23R, STAT3, IL12B, and STAT4 on the risk of aplastic anemia and the effect of immunosuppressive therapy.

  29846833   Preliminary Report on the Association Between STAT3 Polymorphisms and Susceptibility to Acute Kidney Injury After Cardiopulmonary Bypass.

  29967744   Association of Crohn's disease-associated chromosome 1q32 with ankylosing spondylitis is independent of bowel symptoms and fecal calprotectin.

  30399423   SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, LIPC rs10468017, rs493258 and LPL rs12678919 genotypes and haplotype evaluation in patients with age-related macular degeneration.

  30568945   Genetic associations of inflammatory bowel disease in a South Asian population.

  30628197   Could a chimeric condition be responsible for unexpected genetic syndromes? The role of the single nucleotide polymorphism-array analysis.

  31199170   Does CETP rs5882, rs708272, SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, VEGFA rs833068, IL6 rs1800795 polymorphisms play a role in optic neuritis development?

  31321245   Genotypic STAT3 variant rs744166 and increased STAT3 tyrosine phosphorylation in IL-23-sensitive innate lymphoid cells during Crohn's disease pathogenesis.

  31781300   Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma.

  32016989   The effect of single nucleotide polymorphisms of STAT3 on epilepsy in children.

  32320824   Association of IL27 and STAT3 genetic polymorphism on the susceptibility of tuberculosis in Western Chinese Han population.

  34539646   Targeting the Interleukin-23/Interleukin-17 Inflammatory Pathway: Successes and Failures in the Treatment of Axial Spondyloarthritis.

  34656742   Multilocus evaluation of genetic predictors of multiple sclerosis.

  34834553   Innate-Immunity Genes in Obesity.

  35154322   Single Nucleotide Polymorphism of Genes Associated with Metabolic Fatty Liver Disease.

  35327350   The Role of Genetic Factors in the Development of Acute Respiratory Viral Infection COVID-19: Predicting Severe Course and Outcomes.

  36092187   Novel Association between STAT3 Gene Variant and Vitiligo: A Case-Control Study.