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SNP information rs6269


Normal allele: AA

Catechol-O-methyltransferase (COMT) breakdown is associated with increased pain sensitivity in humans and in the development of chronic widespread pain, fibromyalgia.

Polymorphism rs6269 is related to topics like this:

Dopamine transporter genes

The membrane-bound protein called the dopamine transporter (DAT), also known as the...

Research and publications:

  16848906   Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans

  16882734   Genetic predictors for acute experimental cold and heat pain sensitivity in humans

  17961261   Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia

  18574484   The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase

  18698234   Association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, response to levodopa treatment and complications.

  18802928   Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.

  19094200   Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.

  19193196   Genetic contributions to pain: a review of findings in humans.

  19290789   Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment.

  19605537   Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children.

  19772600   A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data.

  20531207   The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.

  20570835   No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain.

  20627703   The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.

  20842020   Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity.

  20863768   Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.

  21197301   Recent advances in the use of opioids for cancer pain.

  21225419   Gene-environment interactions: early life stress and risk for depressive and anxiety disorders.

  21289622   Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.

  21300128   COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa.

  21304959   Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.

  21355050   A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).

  21423693   Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.

  21462137   [An association study of COMT gene polymorphisms with schizophrenia].

  21527290   Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood.

  21940152   The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder--a European multicenter study.

  22105624   The genetics of attention deficit/hyperactivity disorder in adults, a review.

  22178088   Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome.

  22194877   Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding.

  22348792   A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia.

  22451510   Catechol-o-methyltransferase gene and executive function in children with ADHD.

  22528689   Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene.

  22623973   An improved PSO algorithm for generating protective SNP barcodes in breast cancer.

  22890010   Association of COMT, MTHFR and SLC19A1(RFC-1) polymorphisms with blood homocysteine ​​levels and cognitive impairment in Parkinson's disease.

  23178897   The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.

  23766564   Pharmacogenetics of chronic pain and its treatment.

  24178190   Influence of variation in the catechol-O-methyltransferase gene on the clinical outcome after lumbar spine surgery for one-level symptomatic disc disease: a report on 176 cases.

  24684248   Functional polymorphisms in COMT and SLC6A4 genes influence the prognosis of patients with medication overuse headache after withdrawal therapy.

  24755993   Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences?

  24782743   Association of COMT and COMT-DRD2 interaction with creative potential.

  25040948   The design and methods of genetic studies on acute and chronic postoperative pain in patients after total knee replacement.

  25218601   Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.

  25532715   COMT gene haplotypes are closely associated with postoperative fentanyl dose in patients.

  25599448   Association of functional variations in COMT and GCH1 genes with postherniotomy pain and related impairment.

  25772090   Catechol-O-methyltransferase (COMT) gene polymorphisms are associated with baseline disability but not long-term treatment outcome in patients with chronic low back pain.

  26282453   Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population.

  26483654   Linking unfounded beliefs to genetic dopamine availability.

  26849490   Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.

  27028297   A Complex Systems Approach to Causal Discovery in Psychiatry.

  27294121   Detecting Susceptibility to Breast Cancer with SNP-SNP Interaction Using BPSOHS and Emotional Neural Networks.

  27636225   An Expert Review of Pharmacogenomics of Sickle Cell Disease Therapeutics: Not Yet Ready for Global Precision Medicine.

  27903758   OPRM1 and COMT Gene-Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma.

  28451382   Role of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson's disease.

  28740224   Genetic variants in depression and catechol-O-methyltransferase (COMT) are associated with pain in Parkinson's disease.

  28822116   Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.

  28927418   A systematic review and integrative approach to decipher the overall molecular link between levodopa response and Parkinson's disease.

  29195501   COMT genotype and non-recovery after a whiplash injury in a Northern European population.

  29205277   Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon.

  29330410   The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.

  29331705   Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: A prospective birth cohort study.

  29439855   Genetic variants of catechol-O-methyltransferase (COMT) are associated with cognitive decline in patients with Parkinson's disease.

  29550002   Pulp Sensitivity: Influence of Sex, Psychosocial Variables, COMT Gene, and Chronic Facial Pain.

  29559808   Association of genetic variation in COMT gene with pain related to sickle cell disease in patients from the walk-PHaSST study.

  29760667   A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese.

  30093869   Biological Predictors of Clozapine Response: A Systematic Review.

  30811655   The association of genetic polymorphisms in serotonin transporter and catechol-O-methyltransferase on temporomandibular disorders and anxiety in adolescents.

  30822160   Association of COMT gene variability with pain intensity in patients after total hip replacement.

  30886988   Association of Catechol-O-methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients.

  31033149   Genetic influences on the variability of response to repetitive transcranial magnetic stimulation in human pharyngeal motor cortex.

  31129315   Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain.

  31285095   Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients.

  31806881   OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study.

  32034175   COMT-Polymorphisms Modulated Functional Profile of the Fusiform Face Area Contributes to Face-Specific Recognition Ability.

  32217888   Genetic predictors to acupuncture response for hot flashes: an exploratory study of breast cancer survivors.

  32471213   Bruxism Throughout the Lifespan and Variants in MMP2, MMP9 and COMT.

  32961632   Is catechol-O-methyltransferase gene associated with temporomandibular disorders? A systematic review and meta-analysis.

  33303340   OXTR rs53576 Variation with Breast and Nipple Pain in Breastfeeding Women.

  33400997   Sensory and Psychological Factors Predict Exercise-Induced Shoulder Injury Responses in a High-Risk Phenotype Cohort.

  33453563   Association between COMT methylation and response to treatment in children with ADHD.

  33986613   MAOB rs3027452 Modifies Mood Improvement After Tryptophan Supplementation.

  34156736   Genetic variation in catechol-O-methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects.

  34273191   Factors associated with orthodontic pain.

  34682575   Association of COMT Polymorphisms with Multiple Physical Activity-Related Injuries among University Students in China.

  35140610   Genetic Factors Associated With Tardive Dyskinesia: From Pre-clinical Models to Clinical Studies.

  35207633   The Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome.

  35537344   From saliva to SNP: non-invasive, point-of-care genotyping for precision medicine applications using recombinase polymerase amplification and giant magnetoresistive nanosensors.

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