SNP information rs3194051

Research and publications:

  15674389   Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis.

  17554260   Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

  17660816   Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.

  18563381   Study of the association between the CAPSL-IL7R locus and type 1 diabetes.

  19221116   Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.

  19359276   Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

  19956108   Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.

  21297633   Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

  21875636   Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination.

  23818875   DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts.

  24033266   A systematic approach to assessing the clinical significance of genetic variants.

  24728327   Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing.

  24911414   Allele-specific methylation occurs at genetic variants associated with complex disease.

  25236396   Association between IL7RA polymorphisms and the successful therapy against HCV in HIV/HCV-coinfected patients.

  26123260   Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study.

  28446795   Variants in the IL7RA gene confer susceptibility to multiple sclerosis in Caucasians: evidence based on 9734 cases and 10436 controls.

  28487959   Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.

  29742149   The IL7RA rs6897932 polymorphism is associated with progression of liver fibrosis in patients with chronic hepatitis C: Repeated measurements design.

  31817502   Deleterious and Oncogenic Mutations in the IL7RA.

  32111053   Association of Multiple Sclerosis Phenotypes with Single Nucleotide Polymorphisms of IL7R, LAG3, and CD40 Genes in a Jordanian Population: A Genotype-Phenotype Study.

  35907923   IL-7/IL7R axis dysfunction in adults with severe community-acquired pneumonia (CAP): a cross-sectional study.