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KCNT1 potassium sodium-activated channel

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A vast group of genes responsible for the production of potassium channels includes the KCNT1 gene. These channels facilitate movement of positively charged ions (potassium) to and from cells, thereby contributing significantly towards a cell's electrical signal generation and transmission capacity.

The function of a potassium channel is determined by its protein composition and location within the body. KCNT1-based channels are functional in brain nerve cells, facilitating the extrusion of potassium ions from these cells. This ion stream plays an integral role in producing currents that prompt neuron excitation and signal transmission throughout the brain.

Several protein components (subunits) make up potassium channels. The hole (pore), through which potassium ions move, is formed by four alpha subunits in each channel. Channels can be comprised of four alpha subunits from the KCNT1 gene and may also function when interacting with alpha subunits produced from the KCNT2 gene.

Studies indicate that the activation of channels composed of KCNT1 protein can be enhanced by PKC molecules. Although these channels are capable of producing electrical currents in the absence of PKC, their potency increases significantly with its presence.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Potassium and see a list of existing studies.

SNP polymorphisms related to the topic Potassium:

rs3453Potassium channel regulatory subunit gene associated with risk of hearing loss.
rs3842
rs727957
rs1128503
rs1805127Polymorphism of the gene encoding the human minimal potassium ion channel (minK).
rs1892593
rs1922240
rs2030114
rs2032583
rs2032588
rs2211698
rs2234916Potassium channel gene polymorphisms and increased risk of heart disease.
rs2235033
rs2247810
rs2834485
rs3213619
rs3747802
rs3789243
rs4148737
rs4148740
rs7218917
rs7787082
rs9282564
rs9894841
rs10276036
rs10808071
rs10854373
rs10930597
rs11088283
rs11887188
rs12079419
rs12720067
rs13050198
rs16890334
rs55852620
rs62070884
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