RS4998386 information about SNP DNA

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Normal allele: CC

A polymorphism in the NMDA glutamate ionotropic receptor type 2A subunit 2A (GRIN2A) gene causes at least a 5-fold higher risk of Parkinson's disease when interacting with caffeine.

Polymorphism rs4998386 is related to topics like this:

Parkinson is a genetic disease

A disorder that progresses gradually within the nervous system is known as Parkinson's disease. It...

Research and publications:

21876681 A genome-wide gene environment study identifies the glutamate receptor gene GRIN2A as a modifier gene for Parkinson's disease through interaction with coffee.

23644918 Variants in glutamatergic and dopaminergic pathway candidate genes do not influence the onset of Huntington's motor disease.

23820649 Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

24915238 Interaction of caffeine with the glutamate receptor gene GRIN2A: Parkinson's disease in a Swedish population.

26942037 Genetic profile, environmental exposures and their interactions in Parkinson's disease.

29318639 Interaction of caffeine and glutamate ionotropic receptor NMDA type 2A subunit (GRIN2A) and cytochrome P450 1A2 (CYP1A2) polymorphisms on the risk of Parkinson's disease.

31942532 Glutamate ionotropic receptor NMDA receptor gene polymorphism 2A (GRIN2A) (rs4998386) and susceptibility to Parkinson's disease: a meta-analysis.

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