SNP information rs34637584

Research and publications:

  15680455   Genetic screening for the single common LRRK2 mutation in familial Parkinson's disease.

  15680456   A common LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.

  15680457   Common LRRK2 mutation in idiopathic Parkinson's disease.

  15726496   Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations.

  15732108   Clinical and positron emission tomography imaging of Parkinson's disease caused by LRRK2.

  15811455   LRRK2 mutations and Parkinsonism.

  15852371   Clinical features of LRRK2-related Parkinson's disease in central Norway.

  15929036   Genetic and clinical identification of Parkinson's disease patients with the LRRK2 G2019S mutation.

  16145815   LRRK2 haplotype analyses in European and North African families with Parkinson disease: a common founder for the G2019S mutation dating from the 13th century.

  16240353   G2019S LRRK2 mutation in French and North African families with Parkinson's disease.

  16269541   Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 increase kinase activity.

  16311269   Genetics of Parkinson's disease: increase in LRRK2.

  16401756   Analysis of the LRRK2 G2019S mutation in Alzheimer Disease.

  16436781   LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs.

  16436782   LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

  16533964   LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance.

  16728648   Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease.

  16960813   LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago.

  16966502   Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations.

  17050822   Frequency of LRRK2 mutations in early- and late-onset Parkinson disease.

  17060595   LRRK2 mutations on Crete: R1441H associated with PD evolving to PSP.

  17215492   Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease.

  17353388   LRRK2 exon 41 mutations in sporadic Parkinson disease in Europeans.

  17938369   The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinson disease: is there a gender effect?

  18704525   Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease.

  18981379   Is the common LRRK2 G2019S mutation related to dyskinesias in North African Parkinson disease?

  19020907   The LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but the relative prevalence is determined by ethnicity.

  19283415   Ashkenazi Parkinson's disease patients with the LRRK2 G2019S mutation share a common founder dating back to the second to fifth centuries.

  20008657   Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease.

  20186690   Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.

  20301387   LRRK2 Parkinson Disease.

  21115957   Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

  21738487   Genome-wide internet-based association study identifies two new loci and a significant genetic component of Parkinson's disease.

  21812969   Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population.

  21850687   Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death.

  21885347   Association of LRRK2 exonic variants with Parkinson's disease susceptibility: a case-control study.

  22892372   Using genome-wide integrated trait analysis to quantify “missing heritability” in Parkinson's disease.

  23075850   Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.

  23820649   Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

  27094865   Resequencing analysis of five Mendelian genes and top genes from genome-wide association studies in Parkinson's disease.

  27494614   Big data predictive analytics: Parkinson's disease research using large, complex, heterogeneous, inconsistent, multi-source, and incomplete observations.

  28927418   A systematic review and integrative approach to decipher the overall molecular link between levodopa response and Parkinson's disease.

  30154511   Self-report data as a tool for identifying subtypes of genetically determined Parkinson's disease.

  30665447   Dementia with Lewy bodies: an update and outlook.

  30665703   Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting.

  31292011   Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson's disease.

  33494262   Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism.

  33561612   Genetic variants in levodopa-induced dyskinesia (LID): A systematic review and meta-analysis.

  34109443   An attempt to isolate a peripheral marker based on cellular pathology in Parkinson's disease.

  35046417   The QChip1 knowledgebase and microarray for precision medicine in Qatar.