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SNP information rs662

Normal allele: CC

Antioxidant defence enzyme gene breakdown.

Polymorphism rs662 is related to topics like this:

DNA oxidation

Cancer may be linked to oxidative damage of DNA from various chemical and physical agents, but...

Research and publications:

  7916578   Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes.

  8098250   The molecular basis of the human serum paraoxonase activity polymorphism.

  8675673   A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.

  8770857   The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary artery disease in Finns.

  9215303   Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus.

  9385372   The Arg192 isoform of paraoxonase with low sarin-hydrolyzing activity is dominant in the Japanese.

  9443884   Paraoxonase-gene polymorphisms associated with coronary heart disease: support for the oxidative damage hypothesis?

  11238489   The BB-paraoxonase genotype is associated with impaired brachial reactivity after acute hypertriglyceridemia in healthy subjects.

  11810302   Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm.

  11888590   Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip.

  12082503   Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.

  15241482   Paraoxonase 1 polymorphisms and survival.

  17702780   Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis.

  17975119   Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.

  18034366   Lack of replication of genetic associations with human longevity

  18194558   A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.

  18203168   Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts

  18282109   Adaptations to climate in candidate genes for common metabolic disorders

  18513389   New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  18603647   Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response

  18618303   A common haplotype within the PON1 promoter region is associated with sporadic ALS.

  18682580   Oxidative response gene polymorphisms and risk of adult brain tumors.

  18708400   Genetic polymorphisms in the Paraoxonase 1 gene and risk of ovarian epithelial carcinoma.

  18787196   Segment-specific genetic effects on carotid intima-media thickness: the Northern Manhattan study.

  18936436   Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994

  19041386   Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

  19104460   Interaction between PON1 and population density in amyotrophic lateral sclerosis.

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19276285   Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.

  19321847   A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.

  19357718   Genetic polymorphisms of paraoxonase-1 are associated with chronic kidney disease in Japanese women.

  19587357   A systematic meta-analysis of genetic association studies for diabetic retinopathy

  19651761   The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies.

  19736056   Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma.

  19778663   Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention.

  20031584   Genetics of atherothrombotic and lacunar stroke

  20056567   Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.

  20140262   Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.

  20227257   Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians

  20381198   Lack of association of PON polymorphisms with sporadic ALS in an Italian population.

  20488557   Decreased serum arylesterase activity in autism spectrum disorders.

  20529763   Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.

  20616999   Usefulness of Mendelian randomization in observational epidemiology.

  20839225   Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children.

  20856122   Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.

  20980077   Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.

  21054877   Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

  21122033   Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients.

  21146954   Genes and abdominal aortic aneurysm

  21170047   Paraoxonase-1 is a major determinant of clopidogrel efficacy.

  21223581   Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.

  21231776   C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging.

  21438666   Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes.

  21543280   Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik.

  21567207   Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.

  21609220   Genetics of age-related macular degeneration: current concepts, future directions.

  21629682   Paraoxonase 1 (PON1) polymorphisms, haplotypes and activity in predicting cad risk in North-West Indian Punjabis.

  21685174   Paraoxonase-1 Q192R polymorphism and antiplatelet effects of clopidogrel in patients undergoing elective coronary stent placement.

  21852972   Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis.

  21881565   Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.

  21894447   Are centenarians genetically predisposed to lower disease risk?

  21918509   Pharmacogenomics: application to the management of cardiovascular disease.

  21921273   Cardiovascular pharmacogenomics.

  22133529   Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: a meta-analysis.

  22187169   A new PCR method: one primer amplification of PCR-CTPP products.

  22190063   Predicting clopidogrel response using DNA samples linked to an electronic health record.

  22206979   Genetic variants in antioxidant genes are associated with sperm DNA damage and risk of male infertility in a Chinese population.

  22303384   Whole genome sequences of a male and female supercentenarian, ages greater than 114 years.

  22328972   A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes.

  22424094   Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study.

  22427735   Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response.

  22520065   Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis.

  22553514   Single nucleotide polymorphisms of metabolic syndrome-related genes in primary open angle glaucoma.

  22577559   Novel associations of nonstructural Loci with paraoxonase activity.

  22615820   Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age.

  22685667   Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease.

  22723959   Paraoxonase-1 is not a major determinant of stent thrombosis in a Taiwanese population.

  22792358   Association between genetic variants in DNA and histone methylation and telomere length.

  22884547   Association analysis of PON polymorphisms in sporadic ALS in a Chinese population.

  22938532   Sequencing and analysis of a South Asian-Indian personal genome.

  22976839   NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution.

  23049851   Potential of ayurgenomics approach in complex trait research: leads from a pilot study on rheumatoid arthritis.

  23259684   Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study.

  23319877   Association between ABCB1 Polymorphisms and Ischemic Stroke in Korean Population.

  23422753   Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia.

  23497168   Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population.

  23625196   The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects.

  23651475   Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study.

  23697979   Pharmacogenomics of anti-platelet therapy: how much evidence is enough for clinical implementation?

  23797323   Pharmacogenomics of anti-platelet and anti-coagulation therapy.

  23903878   Prenatal methylmercury exposure and genetic predisposition to cognitive deficit at age 8 years.

  23917967   Association of paraoxonase 1 gene polymorphism and enzyme activity with carotid plaque in rheumatoid arthritis.

  24100645   Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy.

  24130171   Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study.

  24448003   Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults.

  24562334   Genetics of oxidative stress in obesity.

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