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SNP information rs6025


Normal allele: CC

The rs6025(A) allele encodes a mutation known as the Leiden mutation, R506Q, an 11.4-fold increased risk of venous thromboembolism.

Polymorphism rs6025 is related to topics like this:

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Research and publications:

  7586244   Factor V Leiden and risks of recurrent idiopathic venous thromboembolism.

  7803250   High prevalence of a mutation in the factor V gene within the U.K. population: relationship to activated protein C resistance and familial thrombosis.

  7877648   Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men.

  7910348   Activated protein C resistance caused by Arg506Gln mutation in factor Va.

  7911872   Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V.

  7968118   Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation.

  8049422   Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families.

  8164730   Human genetics. Bad blood by mutation.

  8164741   Mutation in blood coagulation factor V associated with resistance to activated protein C.

  8566967   Population study of the G1691A mutation (R506Q, FV Leiden) in the human factor V gene that is associated with resistance to activated protein C.

  8616100   HELLP syndrome associated with factor V R506Q mutation.

  8822583   Inherited prethrombotic disorders and infectious purpura.

  9245936   Prevalence of the factor V Leiden mutation in hepatic and portal vein thrombosis.

  9339109   The prevalence of factor V Leiden (1691 G-->A) mutation in Turkey.

  9372726   Retinal arterial occlusion in a child with factor V Leiden and thermolabile methylene tetrahydrofolate reductase mutations

  9415695   Prevalence of the factor V-Leiden mutation in four distinct American ethnic populations.

  9454741   A novel mutation of Arg306 of factor V gene in Hong Kong Chinese.

  9459326   Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss--a possible evolutionary selection mechanism.

  9518910   Case-control study of risk of cerebral sinus thrombosis in oral contraceptive users and in [correction of who are] carriers of hereditary prothrombotic conditions. The Cerebral Venous Sinus Thrombosis Study Group.

  9734642   Budd-Chiari syndrome, portal vein and mesenteric vein thrombosis in a patient homozygous for factor V Leiden mutation treated by TIPS and thrombolysis.

  10328130   Homozygous factor V Leiden mutation in a child with Budd-Chiari syndrome.

  10348711   Simultaneous genotyping for factor V Leiden and prothrombin G20210A variant by a multiplex PCR-SSCP assay on whole blood.

  10477778   The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation.

  10494770   Familial coagulation factor V deficiency caused by a novel 4 base pair insertion in the factor V gene: factor V Stanford.

  10507841   Double-homozygosity for factor V Leiden and the prothrombin gene G20210A variant in a young patient with idiopathic venous thrombosis.

  10666427   Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium.

  11018168   Mutations in coagulation factors in women with unexplained late fetal loss.

  11583312   Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism.

  11686338   Improved hemoglobin status and reduced menstrual blood loss among female carriers of factor V Leiden--an evolutionary advantage?

  12069454   Venous thromboembolism in young women; role of thrombophilic mutations and oral contraceptive use.

  14996674   Factor V Leiden and the risk for venous thromboembolism in the adult Danish population.

  15208046   Venous thromboembolic disease in users of low-estrogen combined estrogen-progestin oral contraceptives.

  15534175   Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls

  15638861   R255h amino acid substitution of protein Z identified in patients with factor V Leiden mutation.

  15946211   Prothrombotic conditions, oral contraceptives, and the risk of ischemic stroke.

  16493002   Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24,000 years ago.

  16769590   Oral contraceptive use, thrombophilia and their interaction in young women with ischemic stroke.

  16846490   Lemierre's syndrome and genetic polymorphisms: case report

  17048007   Association of warfarin dose with genes involved in its action and metabolism

  17107626   Comparison of PrASE and Pyrosequencing for SNP Genotyping

  17677000   Combined effects of thrombosis pathway gene variants predict cardiovascular events.

  18513389   New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  18752569   Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis.

  18805967   Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping.

  18936436   Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19330901   Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study

  19415820   The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study.

  19536175   Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.

  19538716   Genetic risk factors for thrombosis and pharmacogenetic variants of warfarin in a healthy population of San Miguel (Azores).

  19559392   A candidate gene association study of 77 polymorphisms in migraine

  19591822   Prevalence of genetic thrombophilic polymorphisms in the Sri Lankan population--implications for association study design and clinical genetic testing services

  19682239   Replication of findings on the association of genetic variation in 24 hemostasis genes and risk of incident venous thrombosis.

  19786296   Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction.

  20031567   Assessing candidate inflammatory and thrombotic genes for venous thromboembolism risk: the Women's Genome Health Study.

  20352152   Association of common genetic variations and idiopathic venous thromboembolism. Results from EDITh, a hospital-based case-control study.

  20417488   Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years

  20556870   CLIA-tested genetic variants on commercial SNP arrays: potential for incidental findings in genome-wide association studies

  21054877   Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

  21116184   Factor V Leiden thrombophilia.

  21121051   The reference human genome demonstrates high risk of type 1 diabetes and other disorders.

  21163921   Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis.

  21291465   The association of genetic polymorphisms with cerebral palsy: a meta-analysis.

  21332313   Sequence variations in the FII, FV, F13A1, FGB and PAI-1 genes are associated with differences in myocardial perfusion.

  21422408   Clotting factor gene polymorphisms and colorectal cancer risk.

  21463476   Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism.

  21502573   Genetic predictors of fibrin D-dimer levels in healthy adults.

  21564075   Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism.

  21659962   Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates

  21857382   Candidate genes and risk for CP: a population-based study.

  21894447   Are centenarians genetically predisposed to lower disease risk?

  21919968   Validation of genetic variants associated with early acute rejection in kidney allograft transplantation.

  21935354   Phased whole-genome genetic risk in a family quartet using a major allele reference sequence.

  21955043   Validation of single nucleotide polymorphisms associated with acute rejection in kidney transplant recipients using a large multi-center cohort.

  22273812   Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey.

  22295056   Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.

  22353194   Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genes.

  22388798   Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.

  22403240   Associations between incident ischemic stroke events and stroke and cardiovascular disease-related genome-wide association studies single nucleotide polymorphisms in the Population Architecture Using Genomics and Epidemiology study.

  22421107   The G534E-polymorphism of the gene encoding the factor VII-activating protease is a risk factor for venous thrombosis and recurrent events.

  22540831   Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women.

  22707612   Genetic risk factors for thrombosis in systemic lupus erythematosus.

  22879966   Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study.

  22992668   Pharmacogenomics knowledge for personalized medicine.

  23016735   Personalized approach of medication by indirect anticoagulants tailored to the patient-Russian context: what are the prospects?

  23018527   Necessity and risks of arterial blood sampling in healthy volunteer studies.

  23132613   Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis.

  23150947   Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study.

  23274712   Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.

  23533563   Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.

  23650146   A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.

  23776350   Gene polymorphisms in association with self-reported stroke in US adults.

  23820649   Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

  23900608   Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls.

  24270849   Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data.

  24485400   Influence of factor 5 rs6025 and factor 2 rs1799963 mutation on inhibitor development in patients with hemophilia A--an Israeli-German multicenter database study.

  24816905   Single nucleotide variants in the protein C pathway and mortality in dialysis patients.

  24908450   A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups.

  25266489   Genetic polymorphisms of VIP variants in the Tajik ethnic group of northwest China.

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