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SNP information rs5186

Normal allele: AA

A polymorphism known as A1166C, one of the most studied genes, is associated with an increased risk of essential hypertension with an odds ratio of 7.3 (CC homozygote).

Polymorphism rs5186 is related to topics like this:

Abnormally high blood pressure in the arteries, which transport blood from the heart to the rest of...


Research and publications:

  8021009   Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

  9084931   Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension.

  15042429   A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen gene.

  16175505   Identification of four gene variants associated with myocardial infarction.

  17173513   No association between variants in the ACE and angiotensin II receptor 1 genes and acute mountain sickness in Nepalese pilgrims to the Janai Purnima Festival at 4380 m.

  17207964   Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels.

  17211857   Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits.

  17588946   The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding.

  18069999   Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study.

  18224312   Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

  18279468   Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure.

  18413494   Hereditary determinants of human hypertension: strategies in the setting of genetic complexity.

  18513389   New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  18637188   RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population.

  18641512   Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: a HuGE review.

  18698212   Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study.

  18953568   Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19274051   Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men.

  19290790   MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine

  19330904   Genetic polymorphisms of the angiotensin II type 1 receptor gene and diastolic heart failure.

  19336370   Determination of genetic predisposition to patent ductus arteriosus in preterm infants.

  19371411   dbSMR: a novel resource of genome-wide SNPs affecting microRNA mediated regulation.

  19379518   Development of a fingerprinting panel using medically relevant polymorphisms.

  19559392   A candidate gene association study of 77 polymorphisms in migraine

  19587357   A systematic meta-analysis of genetic association studies for diabetic retinopathy

  19716087   Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk.

  19898265   PharmGKB summary: very important pharmacogene information for angiotensin-converting enzyme.

  19954723   The A1166C polymorphism of angiotensin II Type 1 receptor as a predictor of renal function decline over 4 years follow-up in an apparently healthy Chinese population.

  20308035   Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis.

  20428464   MicroRNA polymorphisms: a giant leap towards personalized medicine

  20486282   Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure.

  20521218   Progress toward genetic tailoring of heart failure therapy.

  20565774   Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project

  20570668   Genetic associations with mountain sickness in Han and Tibetan residents at the Qinghai-Tibetan Plateau.

  20577119   Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.

  20592051   Interactions among related genes of renin-angiotensin system associated with type 2 diabetes.

  20621252   The genetics of vascular complications in diabetes mellitus.

  20732682   A1166C genetic variation of the angiotensin II type I receptor gene and susceptibility to coronary heart disease: collaborative of 53 studies with 20,435 cases and 23,674 controls.

  20809528   MicroSNiPer: a web tool for prediction of SNP effects on putative microRNA targets.

  20810793   Endothelial nitric oxide synthase gene variation associated with chronic kidney disease after liver transplant.

  20811292   Genetic variants in the renin-angiotensin system and blood pressure reactions to the cold pressor test.

  20856803   Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems.

  20864943   Early inflammatory and metabolic changes in association with AGTR1 polymorphisms in prehypertensive subjects.

  20948563   Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System: Is There a MicroRNA Connection?

  20981351   Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study.

  21058046   Genetics of salt-sensitive hypertension.

  21127830   Genetic associations in diabetic nephropathy: a meta-analysis.

  21146954   Genes and abdominal aortic aneurysm

  21304999   Epistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.

  21316998   A polymorphism in the angiotensin II type 1 receptor gene has different effects on the risk of diabetic nephropathy in men and women.

  21346624   Interactive effect of angiotensin II type 1 receptor (AGT1R) polymorphisms and plasma irbesartan concentration on antihypertensive therapeutic responses to irbesartan.

  21395978   MicroRNAs and cardiovascular diseases.

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21576655   Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle.

  21671168   Association of polymorphisms in angiotensin II receptor genes with aldosterone-producing adenoma.

  21771600   A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia.

  21799445   Genetic variants in the renin-angiotensin-aldosterone system and blood pressure responses to potassium intake.

  21894447   Are centenarians genetically predisposed to lower disease risk?

  21995669   A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS.

  22024213   A novel gene-environment interaction involved in endometriosis

  22348086   miRNA-mediated relationships between Cis-SNP genotypes and transcript intensities in lymphocyte cell lines.

  22400124   Genomic research to identify novel pathways in the development of abdominal aortic aneurysm.

  22433249   Genetic polymorphisms located in TGFB1, AGTR1, and VEGFA genes are associated to chronic renal allograft dysfunction.

  22569109   The role of renin-angiotensin-aldosterone system polymorphisms in phenotypic expression of MYBPC3-related hypertrophic cardiomyopathy.

  22645060   Association study of angiotensin II type 1 receptor: A1166C (rs5186) polymorphism with coronary heart disease using systematic meta-analysis.

  22879966   Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study.

  23081748   ACACĪ² gene (rs2268388) and AGTR1 gene (rs5186) polymorphism and the risk of nephropathy in Asian Indian patients with type 2 diabetes.

  23132613   Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis.

  23173617   MirSNP, a database of polymorphisms altering miRNA target sites, identifies miRNA-related SNPs in GWAS SNPs and eQTLs.

  23339167   Single nucleotide polymorphisms in G protein signaling pathway genes in preeclampsia.

  23437094   Genetic susceptibility to non-necrotizing erysipelas/cellulitis.

  23902432   Lack of association of angiotensin II type 1 receptor A1166C gene polymorphism with the risk of end-stage renal disease.

  24127120   Genetic susceptibility to nosocomial pneumonia, acute respiratory distress syndrome and poor outcome in patients at risk of critical illness.

  24452035   ACE insertion/deletion polymorphism (rs1799752) modifies the renoprotective effect of renin-angiotensin system blockade in patients with IgA nephropathy.

  24491308   Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men.

  24629096   mrSNP: software to detect SNP effects on microRNA binding.

  24722536   Relationship of renin-angiotensin-aldosterone system polymorphisms and phenotypes to mortality in Chinese coronary atherosclerosis patients.

  24801553   Analysis of multiple genetic polymorphisms in aggressive-growing and slow-growing abdominal aortic aneurysms.

  24834361   Update on abdominal aortic aneurysm research: from clinical to genetic studies.

  24981111   Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults.

  24991086   Novel insights into miRNA in lung and heart inflammatory diseases.

  25106527   Genome-wide association study combined with biological context can reveal more disease-related SNPs altering microRNA target seed sites.

  25474356   Highly significant association between two common single nucleotide polymorphisms in CORIN gene and preeclampsia in Caucasian women.

  25512783   Association of genetic variants with diabetic nephropathy.

  25788903   Network-based analysis of the sphingolipid metabolism in hypertension.

  26142106   Epistatic interaction between common AGT G(-6)A (rs5051) and AGTR1 A1166C (rs5186) variants contributes to variation in kidney size at birth.

  26283679   Correlation between renin-angiotensin system gene polymorphisms and essential hypertension in the Chinese Yi ethnic group.

  26335431   Altered erythrocyte membrane protein composition mirrors pleiotropic effects of hypertension susceptibility genes and disease pathogenesis.

  26395033   Angiotensin II type 1 receptor A1166 C (rs5186) gene polymorphism increased risk and severity of psoriasis, contribution to oxidative stress, antioxidant statues, lipid peroxidation and correlation with vascular adhesion protein 1, preliminary r

  26509357   Genetic variants in the renin-angiotensin system predict response to bevacizumab in cancer patients.

  26588355   Lack of Association Between Polymorphisms in AGT and ATR1 and IgA Nephropathy in a Chinese Population.

  26615960   Single nucleotide polymorphisms in AGTR1, TFAP2B, and TRAF1 are not associated with the incidence of patent ductus arteriosus in Japanese preterm infants.

  26667052   The prevalence of unique SNPs in the renin-angiotensin system highlights the need for pharmacogenetics in Indigenous Australians.

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